JBC Oz Biosciences

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.C100084200 on March 16, 2001

J. Biol. Chem., Vol. 276, Issue 21, 17621-17624, May 25, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/21/17621    most recent
C100084200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pritchard, K. A.
Right arrow Articles by Sessa, W. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pritchard, K. A., Jr.
Right arrow Articles by Sessa, W. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

ACCELERATED PUBLICATION
Heat Shock Protein 90 Mediates the Balance of Nitric Oxide and Superoxide Anion from Endothelial Nitric-oxide Synthase*

Kirkwood A. Pritchard Jr.Dagger §||, Allan W. AckermanDagger , Eric R. Gross**, David W. SteppDagger Dagger , Yang ShiDagger , Jason T. Fontana§§, John E. BakerDagger ¶¶, and William C. Sessa§§||||

From the Dagger  Division of Pediatric Surgery, the Departments of § Pharmacology & Toxicology, Dagger Dagger  Physiology, and ¶¶ Biochemistry, the  Cardiovascular Research Center, and the ** Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 and the §§ Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536

The balance of nitric oxide (·NO) and superoxide anion (O&cjs1138;2) plays an important role in vascular biology. The association of heat shock protein 90 (Hsp90) with endothelial nitric-oxide synthase (eNOS) is a critical step in the mechanisms by which eNOS generates ·NO. As eNOS is capable of generating both ·NO and O&cjs1138;2, we hypothesized that Hsp90 might also mediate eNOS-dependent O&cjs1138;2 production. To test this hypothesis, bovine coronary endothelial cells (BCEC) were pretreated with geldanamycin (GA, 10 µg/ml; 17.8 µM) and then stimulated with the calcium ionophore, A23187 (5 µM). GA significantly decreased A23187-stimulated eNOS-dependent nitrite production (p < 0.001, n = 4) and significantly increased A23187-stimulated eNOS-dependent O&cjs1138;2 production (p < 0.001, n = 8). A23187 increased phospho-eNOS(Ser-1179) levels by >1.6-fold over vehicle (V)-treated levels. Pretreatment with GA by itself or with A23187 increased phospho-eNOS levels. In unstimulated V-treated BCEC cultures low amounts of Hsp90 were found to associate with eNOS. Pretreatment with GA and/or A23187 increased the association of Hsp90 with eNOS. These data show that Hsp90 is essential for eNOS-dependent ·NO production and that inhibition of ATP-dependent conformational changes in Hsp90 uncouples eNOS activity and increases eNOS-dependent O&cjs1138;2 production.

* This work was supported in part by Grants HL61414 (to K. A. P.), HL54075 (to J. E. B.), AHA 0020453Z (to Y. S.), and HL 57665, HL 61371, and HL 64793 (to W. C. S.) from the National Institutes of Health.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

|| To whom correspondence should be addressed: Medical College of Wisconsin, Division of Pediatric Surgery, Pharmacology & Toxicology, Cardiovascular Research Center, 8701 Watertown Plank Rd., Milwaukee, WI 53226. Tel.: 414-456-5615; Fax: 414-456-6473; E-mail: KPRITCH@mcw.edu.

|||| An Established Investigator of the American Heart Association.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. E. Oishi, D. A. Wiseman, S. Sharma, S. Kumar, Y. Hou, S. A. Datar, A. Azakie, M. J. Johengen, C. Harmon, S. Fratz, et al.
Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress
Am J Physiol Lung Cell Mol Physiol, November 1, 2008; 295(5): L756 - L766.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Ramirez, J. M. Mejia-Vilet, D. Hernandez, G. Gamba, and N. A. Bobadilla
Radicicol, a heat shock protein 90 inhibitor, reduces glomerular filtration rate
Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1044 - F1051.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
N. Sud, S. M. Wells, S. Sharma, D. A. Wiseman, J. Wilham, and S. M. Black
Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction
Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1407 - C1418.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Cheng, J.-S. Ou, H. Singh, J. R. Falck, D. Narsimhaswamy, K. A. Pritchard Jr., and M. L. Schwartzman
20-Hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H1018 - H1026.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Huang, D. T. Cai, R. Y. R. Chua, D. M. Kemeny, and S. H. Wong
Nitric-oxide Synthase 2 Interacts with CD74 and Inhibits Its Cleavage by Caspase during Dendritic Cell Development
J. Biol. Chem., January 18, 2008; 283(3): 1713 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Sharma, N. Sud, D. A. Wiseman, A. L. Carter, S. Kumar, Y. Hou, T. Rau, J. Wilham, C. Harmon, P. Oishi, et al.
Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, January 1, 2008; 294(1): L46 - L56.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Xu, Y. Shi, J. Wang, D. Jones, D. Weilrauch, R. Ying, B. Wakim, and K. A. Pritchard Jr.
A Heat Shock Protein 90 Binding Domain in Endothelial Nitric-oxide Synthase Influences Enzyme Function
J. Biol. Chem., December 28, 2007; 282(52): 37567 - 37574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Sud, S. Sharma, D. A. Wiseman, C. Harmon, S. Kumar, R. C. Venema, J. R. Fineman, and S. M. Black
Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90
Am J Physiol Lung Cell Mol Physiol, December 1, 2007; 293(6): L1444 - L1453.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Kotamraju, C. L. Willams, and B. Kalyanaraman
Statin-Induced Breast Cancer Cell Death: Role of Inducible Nitric Oxide and Arginase-Dependent Pathways
Cancer Res., August 1, 2007; 67(15): 7386 - 7394.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. M. Dudzinski and T. Michel
Life history of eNOS: Partners and pathways
Cardiovasc Res, July 15, 2007; 75(2): 247 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G. E. Mann, D. J. Rowlands, F. Y.L. Li, P. de Winter, and R. C.M. Siow
Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression
Cardiovasc Res, July 15, 2007; 75(2): 261 - 274.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. L. Aschner, S. L. Foster, M. Kaplowitz, Y. Zhang, H. Zeng, and C. D. Fike
Heat shock protein 90 modulates endothelial nitric oxide synthase activity and vascular reactivity in the newborn piglet pulmonary circulation
Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1515 - L1525.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. G. Konduri, I. Bakhutashvili, A. Eis, and K. Pritchard Jr.
Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension
Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1812 - H1820.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
K. Bedard and K.-H. Krause
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Physiol Rev, January 1, 2007; 87(1): 245 - 313.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
L. Nunez, M. Vaquero, R. Gomez, R. Caballero, P. Mateos-Caceres, C. Macaya, I. Iriepa, E. Galvez, A. Lopez-Farre, J. Tamargo, et al.
Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism
Cardiovasc Res, October 1, 2006; 72(1): 80 - 89.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Oishi, A. Azakie, C. Harmon, R. K. Fitzgerald, A. Grobe, J. Xu, K. Hendricks-Munoz, S. M. Black, and J. R. Fineman
Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs
Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1922 - H1932.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
E. B. Manukhina, H. F. Downey, and R. T. Mallet
Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia.
Experimental Biology and Medicine, April 1, 2006; 231(4): 343 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
N. Ardanaz and P. J. Pagano
Hydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction.
Experimental Biology and Medicine, March 1, 2006; 231(3): 237 - 251.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Jerkic, A. Rodriguez-Barbero, M. Prieto, M. Toporsian, M. Pericacho, J. V. Rivas-Elena, J. Obreo, A. Wang, F. Perez-Barriocanal, M. Arevalo, et al.
Reduced angiogenic responses in adult endoglin heterozygous mice
Cardiovasc Res, March 1, 2006; 69(4): 845 - 854.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. B. Harris, M. Bartoli, S. G. Sood, R. L. Matts, and R. C. Venema
Direct Interaction of the Cell Division Cycle 37 Homolog Inhibits Endothelial Nitric Oxide Synthase Activity
Circ. Res., February 17, 2006; 98(3): 335 - 341.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
B. Musicki and A. L. Burnett
eNOS Function and Dysfunction in the Penis
Experimental Biology and Medicine, February 1, 2006; 231(2): 154 - 165.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
B. J. Davis, Z. Xie, B. Viollet, and M.-H. Zou
Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase
Diabetes, February 1, 2006; 55(2): 496 - 505.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Mata-Greenwood, C. Jenkins, K. N. Farrow, G. G. Konduri, J. A. Russell, S. Lakshminrusimha, S. M. Black, and R. H. Steinhorn
eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally
Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L232 - L241.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. Oishi, A. Grobe, E. Benavidez, B. Ovadia, C. Harmon, G. A. Ross, K. Hendricks-Munoz, J. Xu, S. M. Black, and J. R. Fineman
Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb
Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L359 - L366.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
E. Schulz, E. Anter, M.-H. Zou, and J. F. Keaney Jr
Estradiol-Mediated Endothelial Nitric Oxide Synthase Association With Heat Shock Protein 90 Requires Adenosine Monophosphate-Dependent Protein Kinase
Circulation, June 28, 2005; 111(25): 3473 - 3480.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Toporsian, R. Gros, M. G. Kabir, S. Vera, K. Govindaraju, D. H. Eidelman, M. Husain, and M. Letarte
A Role for Endoglin in Coupling eNOS Activity and Regulating Vascular Tone Revealed in Hereditary Hemorrhagic Telangiectasia
Circ. Res., April 1, 2005; 96(6): 684 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
I. Fleming, A. Mohamed, J. Galle, L. Turchanowa, R. P. Brandes, B. Fisslthaler, and R. Busse
Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKC{alpha}
Cardiovasc Res, March 1, 2005; 65(4): 897 - 906.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. A. Ross, P. Oishi, A. Azakie, S. Fratz, R. K. Fitzgerald, M. J. Johengen, C. Harmon, K. Hendricks-Munoz, J. Xu, S. M. Black, et al.
Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension
Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L27 - L35.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Sun and J. K. Liao
Induction of Angiogenesis by Heat Shock Protein 90 Mediated by Protein Kinase Akt and Endothelial Nitric Oxide Synthase
Arterioscler. Thromb. Vasc. Biol., December 1, 2004; 24(12): 2238 - 2244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Fulton, M. B. Harris, B. E. Kemp, R. C. Venema, M. B. Marrero, and D. W. Stepp
Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2384 - H2393.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. Kupatt, C. Dessy, R. Hinkel, P. Raake, G. Daneau, C. Bouzin, P. Boekstegers, and O. Feron
Heat Shock Protein 90 Transfection Reduces Ischemia-Reperfusion-Induced Myocardial Dysfunction via Reciprocal Endothelial NO Synthase Serine 1177 Phosphorylation and Threonine 495 Dephosphorylation
Arterioscler. Thromb. Vasc. Biol., August 1, 2004; 24(8): 1435 - 1441.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. A. Ortiz, N. J. Hong, and J. L. Garvin
Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. II. Role of PI3-kinase and Hsp90
Am J Physiol Renal Physiol, August 1, 2004; 287(2): F281 - F288.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. S. Billecke, D. I. Draganov, Y. Morishima, P. J. M. Murphy, A. Y. Dunbar, W. B. Pratt, and Y. Osawa
The Role of hsp90 in Heme-dependent Activation of Apo-neuronal Nitric-oxide Synthase
J. Biol. Chem., July 16, 2004; 279(29): 30252 - 30258.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. H. Schwartz, C. A. White, and B. A. Freeman
Do we kNOw how HSP90 and eNOS mediate lung injury in sickle cell disease?
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L701 - L704.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. A. Pritchard Jr., J. Ou, Z. Ou, Y. Shi, J. P. Franciosi, P. Signorino, S. Kaul, C. Ackland-Berglund, K. Witte, S. Holzhauer, et al.
Hypoxia-induced acute lung injury in murine models of sickle cell disease
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L705 - L714.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. J. Alp and K. M. Channon
Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease
Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 413 - 420.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. N. Dedkova, X. Ji, S. L. Lipsius, and L. A. Blatter
Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells
Am J Physiol Cell Physiol, February 1, 2004; 286(2): C406 - C415.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Ou, J. T. Fontana, Z. Ou, D. W. Jones, A. W. Ackerman, K. T. Oldham, J. Yu, W. C. Sessa, and K. A. Pritchard Jr.
Heat shock protein 90 and tyrosine kinase regulate eNOS NO{middle dot} generation but not NO{middle dot} bioactivity
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H561 - H569.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Jiang, D. Cyr, R. W. Babbitt, W. C. Sessa, and C. Patterson
Chaperone-dependent Regulation of Endothelial Nitric-oxide Synthase Intracellular Trafficking by the Co-chaperone/Ubiquitin Ligase CHIP
J. Biol. Chem., December 5, 2003; 278(49): 49332 - 49341.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Nozik-Grayck, Y.-C. T. Huang, M. S. Carraway, and C. A. Piantadosi
Bicarbonate-dependent superoxide release and pulmonary artery tone
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2327 - H2335.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Pantano, P. Shrivastava, B. McElhinney, and Y. Janssen-Heininger
Hydrogen Peroxide Signaling through Tumor Necrosis Factor Receptor 1 Leads to Selective Activation of c-Jun N-terminal Kinase
J. Biol. Chem., November 7, 2003; 278(45): 44091 - 44096.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. I. Lin, D. Fulton, R. Babbitt, I. Fleming, R. Busse, K. A. Pritchard Jr., and W. C. Sessa
Phosphorylation of Threonine 497 in Endothelial Nitric-oxide Synthase Coordinates the Coupling of L-Arginine Metabolism to Efficient Nitric Oxide Production
J. Biol. Chem., November 7, 2003; 278(45): 44719 - 44726.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. S. Sreedhar, K. Mihaly, B. Pato, T. Schnaider, A. Stetak, K. Kis-Petik, J. Fidy, T. Simonics, A. Maraz, and P. Csermely
Hsp90 Inhibition Accelerates Cell Lysis: ANTI-Hsp90 RIBOZYME REVEALS A COMPLEX MECHANISM OF Hsp90 INHIBITORS INVOLVING BOTH SUPEROXIDE- AND Hsp90-DEPENDENT EVENTS
J. Biol. Chem., September 12, 2003; 278(37): 35231 - 35240.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P.B. Massion, O. Feron, C. Dessy, and J.-L. Balligand
Nitric Oxide and Cardiac Function: Ten Years After, and Continuing
Circ. Res., September 5, 2003; 93(5): 388 - 398.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. C. Boo and H. Jo
Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases
Am J Physiol Cell Physiol, September 1, 2003; 285(3): C499 - C508.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Takahashi and M. E. Mendelsohn
Synergistic Activation of Endothelial Nitric-oxide Synthase (eNOS) by HSP90 and Akt: CALCIUM-INDEPENDENT eNOS ACTIVATION INVOLVES FORMATION OF AN HSP90-Akt-CaM-BOUND eNOS COMPLEX
J. Biol. Chem., August 15, 2003; 278(33): 30821 - 30827.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. G. Konduri, J. Ou, Y. Shi, and K. A. Pritchard Jr.
Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension
Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H204 - H211.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
J. Ou, Z. Ou, D. G. McCarver, R. N. Hines, K. T. Oldham, A. W. Ackerman, and K. A. Pritchard Jr.
Trichloroethylene Decreases Heat Shock Protein 90 Interactions with Endothelial Nitric Oxide Synthase: Implications for Endothelial Cell Proliferation
Toxicol. Sci., May 1, 2003; 73(1): 90 - 97.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Takahashi and M. E. Mendelsohn
Calmodulin-dependent and -independent Activation of Endothelial Nitric-oxide Synthase by Heat Shock Protein 90
J. Biol. Chem., March 7, 2003; 278(11): 9339 - 9344.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Koshida, J. Ou, T. Matsunaga, W. M. Chilian, K. T. Oldham, A. W. Ackerman, and K. A. Pritchard Jr
Angiostatin: A Negative Regulator of Endothelial-Dependent Vasodilation
Circulation, February 18, 2003; 107(6): 803 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. Piech, C. Dessy, X. Havaux, O. Feron, and J.-L. Balligand
Differential regulation of nitric oxide synthases and their allosteric regulators in heart and vessels of hypertensive rats
Cardiovasc Res, February 1, 2003; 57(2): 456 - 467.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Fleming and R. Busse
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R1 - R12.