JBC Oz Biosciences

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M008422200 on February 26, 2001

J. Biol. Chem., Vol. 276, Issue 21, 17871-17877, May 25, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/21/17871    most recent
M008422200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sasaki, A.
Right arrow Articles by Watanabe, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sasaki, A.
Right arrow Articles by Watanabe, K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Filamin Associates with Smads and Regulates Transforming Growth Factor-beta Signaling*

Aya SasakiDagger , Yoshiko MasudaDagger , Yasutaka Ohta§, Kyoji IkedaDagger , and Ken WatanabeDagger

From the Dagger  Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi 474-8522, Japan and the § Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115-2248

Members of the Smad proteins transmit signals triggered by the ligands of transforming growth factor (TGF)-beta superfamily. Ligand-activated receptors induce phosphorylation of so-called receptor-regulated Smads, which then accumulate in the nucleus to participate in target gene transcription, in collaboration with Smad-interacting proteins. We performed yeast two-hybrid screening and identified filamin, a cytoskeletal actin-binding protein 280, as a Smad5-interacting protein. Filamin was found to be associated not only with Smad5 but also with other Smad proteins, including TGF-beta /activin receptor-regulated Smad2. TGF-beta signaling was defective in filamin-deficient human melanoma cells M2 compared with a filamin-transfected subline A7, as determined by TGF-beta -responsive reporter gene activation and Smad2 nuclear accumulation. M2 cells restored TGF-beta responsiveness following transient transfection of full-length filamin encoding vector. The defective TGF-beta signaling in M2 cells seemed to be due to impaired receptor-induced serine phosphorylation of Smad2. These results suggest that filamin plays an important role in Smad-mediated signaling.

* This work was supported by a Research Grant for Longevity Sciences from the Ministry of Health and Welfare of Japan (to K. W.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed: Dept. of Geriatric Research, National Inst. for Longevity Sciences, 36-3 Gengo, Morioka-cho, Obu, Aichi 474-8522, Japan. E-mail: kwatanab@nils.go.jp.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Biol. CellHome page
Y. J. Jeon, J. S. Choi, J. Y. Lee, K. R. Yu, S. H. Ka, Y. Cho, E.-J. Choi, S. H. Baek, J. H. Seol, D. Park, et al.
Filamin B Serves as a Molecular Scaffold for Type I Interferon-induced c-Jun NH2-terminal Kinase Signaling Pathway
Mol. Biol. Cell, December 1, 2008; 19(12): 5116 - 5130.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Mori, K. Kitano, S.-i. Terawaki, R. Maesaki, Y. Fukami, and T. Hakoshima
Structural Basis for CD44 Recognition by ERM Proteins
J. Biol. Chem., October 24, 2008; 283(43): 29602 - 29612.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Kwon, E. Hanna, D. Lorang, M. He, J. S. Quick, A. Adem, C. Stevenson, J.-Y. Chung, S. M. Hewitt, E. Zudaire, et al.
Functional Characterization of Filamin A Interacting Protein 1-Like, a Novel Candidate for Antivascular Cancer Therapy
Cancer Res., September 15, 2008; 68(18): 7332 - 7341.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
E. Glasgow and L. Mishra
Transforming growth factor-{beta} signaling and ubiquitinators in cancer
Endocr. Relat. Cancer, March 1, 2008; 15(1): 59 - 72.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
L. Zheng, H.-J. Baek, G. Karsenty, and M. J. Justice
Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner
J. Cell Biol., October 3, 2007; 178(1): 121 - 128.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Charitakis and C. T. Basson
Degenerating Heart Valves: Fill Them up With Filamin?
Circulation, January 2, 2007; 115(1): 2 - 4.
[Full Text] [PDF]

Home page
 CirculationHome page
F. Kyndt, J.-P. Gueffet, V. Probst, P. Jaafar, A. Legendre, F. Le Bouffant, C. Toquet, E. Roy, L. McGregor, S. A. Lynch, et al.
Mutations in the Gene Encoding Filamin A as a Cause for Familial Cardiac Valvular Dystrophy
Circulation, January 2, 2007; 115(1): 40 - 49.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
T. Sjoblom, S. Jones, L. D. Wood, D. W. Parsons, J. Lin, T. D. Barber, D. Mandelker, R. J. Leary, J. Ptak, N. Silliman, et al.
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Science, October 13, 2006; 314(5797): 268 - 274.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Okano, H. W. Schnaper, K. Bomsztyk, and T. Hayashida
RACK1 Binds to Smad3 to Modulate Transforming Growth Factor-beta1-stimulated {alpha}2(I) Collagen Transcription in Renal Tubular Epithelial Cells
J. Biol. Chem., September 8, 2006; 281(36): 26196 - 26204.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
B. M. Zhao and F. M. Hoffmann
Inhibition of Transforming Growth Factor-beta1-induced Signaling and Epithelial-to-Mesenchymal Transition by the Smad-binding Peptide Aptamer Trx-SARA
Mol. Biol. Cell, September 1, 2006; 17(9): 3819 - 3831.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
Q. Luo, E. Nieves, J. Kzhyshkowska, and R. H. Angeletti
Endogenous Transforming Growth Factor-{beta} Receptor-mediated Smad Signaling Complexes Analyzed by Mass Spectrometry
Mol. Cell. Proteomics, July 1, 2006; 5(7): 1245 - 1260.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Y. W. Bourguignon, E. Gilad, A. Brightman, F. Diedrich, and P. Singleton
Hyaluronan-CD44 Interaction with Leukemia-associated RhoGEF and Epidermal Growth Factor Receptor Promotes Rho/Ras Co-activation, Phospholipase C{epsilon}-Ca2+ Signaling, and Cytoskeleton Modification in Head and Neck Squamous Cell Carcinoma Cells
J. Biol. Chem., May 19, 2006; 281(20): 14026 - 14040.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Hoffmann, O. Preobrazhenska, C. Wodarczyk, Y. Medler, A. Winkel, S. Shahab, D. Huylebroeck, G. Gross, and K. Verschueren
Transforming Growth Factor-{beta}-activated Kinase-1 (TAK1), a MAP3K, Interacts with Smad Proteins and Interferes with Osteogenesis in Murine Mesenchymal Progenitors
J. Biol. Chem., July 22, 2005; 280(29): 27271 - 27283.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Zhang and G. E. Breitwieser
High Affinity Interaction with Filamin A Protects against Calcium-sensing Receptor Degradation
J. Biol. Chem., March 25, 2005; 280(12): 11140 - 11146.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. B. Berry, M. A. O'Neill, M. Coca-Prados, and M. A. Walter
FOXC1 Transcriptional Regulatory Activity Is Impaired by PBX1 in a Filamin A-Mediated Manner
Mol. Cell. Biol., February 15, 2005; 25(4): 1415 - 1424.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Yoshida, T. Ogata, K. Tanabe, S. Li, M. Nakazato, K. Kohu, T. Takafuta, S. Shapiro, Y. Ohta, M. Satake, et al.
Filamin A-Bound PEBP2{beta}/CBF{beta} Is Retained in the Cytoplasm and Prevented from Functioning as a Partner of the Runx1 Transcription Factor
Mol. Cell. Biol., February 1, 2005; 25(3): 1003 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. S. Peterson, R. A. Andhare, K. T. Rousche, W. Knudson, W. Wang, J. B. Grossfield, R. O. Thomas, R. E. Hollingsworth, and C. B. Knudson
CD44 modulates Smad1 activation in the BMP-7 signaling pathway
J. Cell Biol., September 27, 2004; 166(7): 1081 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
I. Onoprishvili, M. L. Andria, H. K. Kramer, N. Ancevska-Taneva, J. M. Hiller, and E. J. Simon
Interaction Between the {micro} Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking
Mol. Pharmacol., November 1, 2003; 64(5): 1092 - 1100.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-J. He, S. Kole, Y.-K. Kwon, M. T. Crow, and M. Bernier
Interaction of Filamin A with the Insulin Receptor Alters Insulin-dependent Activation of the Mitogen-activated Protein Kinase Pathway
J. Biol. Chem., July 11, 2003; 278(29): 27096 - 27104.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
U. Tigges, B. Koch, J. Wissing, B. M. Jockusch, and W. H. Ziegler
The F-actin Cross-linking and Focal Adhesion Protein Filamin A Is a Ligand and in Vivo Substrate for Protein Kinase C{alpha}
J. Biol. Chem., June 20, 2003; 278(26): 23561 - 23569.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S.-I. Osada, S.-y. Ohmori, and M. Taira
XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos
Development, May 1, 2003; 130(9): 1783 - 1794.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Takafuta, M. Saeki, T.-T. Fujimoto, K. Fujimura, and S. S. Shapiro
A New Member of the LIM Protein Family Binds to Filamin B and Localizes at Stress Fibers
J. Biol. Chem., March 28, 2003; 278(14): 12175 - 12181.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Jiao, Y. Zhou, and B. L. M. Hogan
Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1
Mol. Cell. Biol., November 1, 2002; 22(21): 7633 - 7644.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Moustakas, S. Souchelnytskyi, and C.-H. Heldin
Smad regulation in TGF-{beta} signal transduction
J. Cell Sci., March 14, 2002; 114(24): 4359 - 4369.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Awata, C. Huang, M. E. Handlogten, and R. T. Miller
Interaction of the Calcium-sensing Receptor and Filamin, a Potential Scaffolding Protein
J. Biol. Chem., September 7, 2001; 276(37): 34871 - 34879.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.