HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 276, Issue 22, 19046-19051, June 1, 2001

This Article Full Text Full Text (PDF) All Versions of this Article: 276/22/19046    most recent M100945200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Majumder, A. Articles by Wu, H.-Y. Search for Related Content PubMed PubMed Citation Articles by Majumder, A. Articles by Wu, H.-Y. Social Bookmarking                      What's this?

LeuO Expression in Response to Starvation for Branched-chain Amino Acids^*

Arundhati Majumder, Ming Fang, Kan-Jen Tsai^§, Chiharu Ueguchi^¶, Takeshi Mizuno, and Hai-Young Wu^**

From the  Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, the ^§ School of Medical Technology, Chung Shan Medical and Dental College, Taichung 402, Taiwan, and the ^¶ BioScience Center and  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan

The recently identified role of LeuO in the regulation of transcription has prompted us to search for the specific function(s) of LeuO in bacterial physiology. The cryptic nature of expression of leuO has previously limited such analysis. A conditional leuO expression was found when bacteria enter stationary phase and was shown to be guanosine 3',5'-bispyrophosphate-dependent. Multiple physiological events, including the stringent response, are induced upon the increase of the bacterial stress signal, guanosine 3',5'-bispyrophosphate. In this study, we tested whether LeuO was directly involved in the bacterial stringent response. LeuO was shown to be indispensable for growth resumption following a 2-h growth arrest caused by starvation for branched-chain amino acids in an E. coli K-12 relA1 strain. This result supports a functional role for LeuO in the bacterial stringent response.

The nucleotide sequence(s) reported in this paper has been submitted to the GenBank^TM/EMBL Data Bank with accession number(s) AF106955.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				T. Shimada, K. Yamamoto, and A. Ishihama Involvement of the Leucine Response Transcription Factor LeuO in Regulation of the Genes for Sulfa Drug Efflux J. Bacteriol., July 15, 2009; 191(14): 4562 - 4571. [Abstract] [Full Text] [PDF]

				M. A. De la Cruz, E. Merino, R. Oropeza, J. Tellez, and E. Calva The DNA static curvature has a role in the regulation of the ompS1 porin gene in Salmonella enterica serovar Typhi Microbiology, July 1, 2009; 155(7): 2127 - 2136. [Abstract] [Full Text] [PDF]

				I. Hernandez-Lucas, A. L. Gallego-Hernandez, S. Encarnacion, M. Fernandez-Mora, A. G. Martinez-Batallar, H. Salgado, R. Oropeza, and E. Calva The LysR-Type Transcriptional Regulator LeuO Controls Expression of Several Genes in Salmonella enterica Serovar Typhi J. Bacteriol., March 1, 2008; 190(5): 1658 - 1670. [Abstract] [Full Text] [PDF]

				M. B. Lawrenz and V. L. Miller Comparative Analysis of the Regulation of rovA from the Pathogenic Yersiniae J. Bacteriol., August 15, 2007; 189(16): 5963 - 5975. [Abstract] [Full Text] [PDF]

				S. Madhusudan, A. Paukner, Y. Klingen, and K. Schnetz Independent regulation of H-NS-mediated silencing of the bgl operon at two levels: upstream by BglJ and LeuO and downstream by DnaKJ Microbiology, October 1, 2005; 151(10): 3349 - 3359. [Abstract] [Full Text] [PDF]

				C.-C. Chen, M.-Y. Chou, C.-H. Huang, A. Majumder, and H.-Y. Wu A Cis-spreading Nucleoprotein Filament Is Responsible for the Gene Silencing Activity Found in the Promoter Relay Mechanism J. Biol. Chem., February 11, 2005; 280(6): 5101 - 5112. [Abstract] [Full Text] [PDF]

				M. Fernandez-Mora, J. L. Puente, and E. Calva OmpR and LeuO Positively Regulate the Salmonella enterica Serovar Typhi ompS2 Porin Gene J. Bacteriol., May 15, 2004; 186(10): 2909 - 2920. [Abstract] [Full Text] [PDF]

				C.-C. Chen, M. Ghole, A. Majumder, Z. Wang, S. Chandana, and H.-Y. Wu LeuO-mediated Transcriptional Derepression J. Biol. Chem., September 26, 2003; 278(39): 38094 - 38103. [Abstract] [Full Text] [PDF]