HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 276, Issue 23, 20085-20092, June 8, 2001

This Article Full Text Full Text (PDF) All Versions of this Article: 276/23/20085    most recent M101143200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yoon, S.-O. Articles by Chung, A.-S. Search for Related Content PubMed PubMed Citation Articles by Yoon, S.-O. Articles by Chung, A.-S.

Inhibitory Effect of Selenite on Invasion of HT1080 Tumor Cells^*

Sang-Oh Yoon, Moon-Moo Kim, and An-Sik Chung

From the Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea

Selenium, an essential biological trace element, has been shown to reduce and prevent the incidence of cancer. Our previous studies have shown that selenite is involved in the chemoprevention of cancer and induction of apoptosis of cancer cells. In this study, we demonstrate that selenite also inhibits the invasion of tumor cells. Cancer cell invasion requires coordinated processes, such as changes in cell-cell and cell-matrix adhesion, degradation of the extracellular matrix, and cell migration. We found that selenite inhibited invasion of HT1080 human fibrosarcoma cells. Adhesion of HT1080 cells to the collagen matrix was also inhibited by treatment with selenite, but cell-cell interaction and cell motility were not affected by selenite. Moreover, selenite reduced expression of matrix metalloproteinase-2 and -9 and urokinase-type plasminogen activator, which are involved in matrix degradation, but increased a tissue inhibitor of metalloproteinase-1. This inhibitory effect of selenite on the protease expressions was mediated by the suppression of transcription factors, NF-B and AP-1. However, selenate showed no remarkable effect on all the steps of cancer cell invasion.

This article has been cited by other articles:

				J.-M. Park, A. Kim, J.-H. Oh, and A.-S. Chung Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-{kappa}B activation Carcinogenesis, April 1, 2007; 28(4): 837 - 847. [Abstract] [Full Text] [PDF]

				S.-O. Yoon, S. Shin, H.-J. Lee, H.-K. Chun, and A.-S. Chung Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol. Cancer Ther., November 1, 2006; 5(11): 2666 - 2675. [Abstract] [Full Text] [PDF]

				S. Hong, K.-K. Park, J. Magae, K. Ando, T.-S. Lee, T. K. Kwon, J.-Y. Kwak, C.-H. Kim, and Y.-C. Chang Ascochlorin Inhibits Matrix Metalloproteinase-9 Expression by Suppressing Activator Protein-1-mediated Gene Expression through the ERK1/2 Signaling Pathway: INHIBITORY EFFECTS OF ASCOCHLORIN ON THE INVASION OF RENAL CARCINOMA CELLS J. Biol. Chem., July 1, 2005; 280(26): 25202 - 25209. [Abstract] [Full Text] [PDF]

				A. Schweinitz, T. Steinmetzer, I. J. Banke, M. J. E. Arlt, A. Sturzebecher, O. Schuster, A. Geissler, H. Giersiefen, E. Zeslawska, U. Jacob, et al. Design of Novel and Selective Inhibitors of Urokinase-type Plasminogen Activator with Improved Pharmacokinetic Properties for Use as Antimetastatic Agents J. Biol. Chem., August 6, 2004; 279(32): 33613 - 33622. [Abstract] [Full Text] [PDF]

				D. Li, G. L. Graef, J. A. Yee, and L. Yan Dietary Supplementation with High-Selenium Soy Protein Reduces Pulmonary Metastasis of Melanoma Cells in Mice J. Nutr., June 1, 2004; 134(6): 1536 - 1540. [Abstract] [Full Text] [PDF]

				N. V. Gopee, V. J. Johnson, and R. P. Sharma Sodium Selenite-Induced Apoptosis in Murine B-Lymphoma Cells Is Associated with Inhibition of Protein Kinase C-{delta}, Nuclear Factor {kappa}B, and Inhibitor of Apoptosis Protein Toxicol. Sci., April 1, 2004; 78(2): 204 - 214. [Abstract] [Full Text] [PDF]

				S. M. Conley, R. L. Bruhn, P. V. Morgan, and W. D. Stamer Selenium's Effects on MMP-2 and TIMP-1 Secretion by Human Trabecular Meshwork Cells Invest. Ophthalmol. Vis. Sci., February 1, 2004; 45(2): 473 - 479. [Abstract] [Full Text] [PDF]

				S. J. Merchant, I. P. Crocker, P. N. Baker, D. Tansinda, S. T. Davidge, and L. J. Guilberg Matrix Metalloproteinase Release From Placental Explants of Pregnancies Complicated by Intrauterine Growth Restriction Reproductive Sciences, February 1, 2004; 11(2): 97 - 103. [Abstract] [PDF]

				Y.-C. Lee, Y.-C. Tang, Y.-H. Chen, C.-M. Wong, and A.-P. Tsou Selenite-induced Survival of HuH7 Hepatoma Cells Involves Activation of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Pathway and Rac1 J. Biol. Chem., October 10, 2003; 278(41): 39615 - 39624. [Abstract] [Full Text] [PDF]

				K. K. Nelson, A. C. Ranganathan, J. Mansouri, A. M. Rodriguez, K. M. Providence, J. L. Rutter, K. Pumiglia, J. A. Bennett, and J. A. Melendez Elevated Sod2 Activity Augments Matrix Metalloproteinase Expression: Evidence for the Involvement of Endogenous Hydrogen Peroxide in Regulating Metastasis Clin. Cancer Res., January 1, 2003; 9(1): 424 - 432. [Abstract] [Full Text] [PDF]