Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M101143200 on March 27, 2001

J. Biol. Chem., Vol. 276, Issue 23, 20085-20092, June 8, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/23/20085    most recent
M101143200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yoon, S.-O.
Right arrow Articles by Chung, A.-S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yoon, S.-O.
Right arrow Articles by Chung, A.-S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Inhibitory Effect of Selenite on Invasion of HT1080 Tumor Cells*

Sang-Oh Yoon, Moon-Moo Kim, and An-Sik ChungDagger

From the Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea

Selenium, an essential biological trace element, has been shown to reduce and prevent the incidence of cancer. Our previous studies have shown that selenite is involved in the chemoprevention of cancer and induction of apoptosis of cancer cells. In this study, we demonstrate that selenite also inhibits the invasion of tumor cells. Cancer cell invasion requires coordinated processes, such as changes in cell-cell and cell-matrix adhesion, degradation of the extracellular matrix, and cell migration. We found that selenite inhibited invasion of HT1080 human fibrosarcoma cells. Adhesion of HT1080 cells to the collagen matrix was also inhibited by treatment with selenite, but cell-cell interaction and cell motility were not affected by selenite. Moreover, selenite reduced expression of matrix metalloproteinase-2 and -9 and urokinase-type plasminogen activator, which are involved in matrix degradation, but increased a tissue inhibitor of metalloproteinase-1. This inhibitory effect of selenite on the protease expressions was mediated by the suppression of transcription factors, NF-kappa B and AP-1. However, selenate showed no remarkable effect on all the steps of cancer cell invasion.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Dept. of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, Korea. Tel.: 82-42-869-2625; Fax: 82-42-869-2610; E-mail: aschung@mail.kaist.ac.kr.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
A. Banning, A. Kipp, S. Schmitmeier, M. Lowinger, S. Florian, S. Krehl, S. Thalmann, R. Thierbach, P. Steinberg, and R. Brigelius-Flohe
Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice
Cancer Res., December 1, 2008; 68(23): 9746 - 9753.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
M. Roomi, T Kalinovsky, N. Roomi, V Ivanov, M Rath, and A Niedzwiecki
A nutrient mixture suppresses carbon tetrachloride-induced acute hepatic toxicity in ICR mice
Human and Experimental Toxicology, July 1, 2008; 27(7): 559 - 566.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
M. Roomi, T Kalinovsky, V Ivanov, M Rath, and A Niedzwiecki
A nutrient mixture prevents acetaminophen hepatic and renal toxicity in ICR mice
Human and Experimental Toxicology, March 1, 2008; 27(3): 223 - 230.
[Abstract] [PDF]

Home page
 CarcinogenesisHome page
J.-M. Park, A. Kim, J.-H. Oh, and A.-S. Chung
Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-{kappa}B activation
Carcinogenesis, April 1, 2007; 28(4): 837 - 847.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S.-O. Yoon, S. Shin, H.-J. Lee, H.-K. Chun, and A.-S. Chung
Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.
Mol. Cancer Ther., November 1, 2006; 5(11): 2666 - 2675.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Hong, K.-K. Park, J. Magae, K. Ando, T.-S. Lee, T. K. Kwon, J.-Y. Kwak, C.-H. Kim, and Y.-C. Chang
Ascochlorin Inhibits Matrix Metalloproteinase-9 Expression by Suppressing Activator Protein-1-mediated Gene Expression through the ERK1/2 Signaling Pathway: INHIBITORY EFFECTS OF ASCOCHLORIN ON THE INVASION OF RENAL CARCINOMA CELLS
J. Biol. Chem., July 1, 2005; 280(26): 25202 - 25209.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Schweinitz, T. Steinmetzer, I. J. Banke, M. J. E. Arlt, A. Sturzebecher, O. Schuster, A. Geissler, H. Giersiefen, E. Zeslawska, U. Jacob, et al.
Design of Novel and Selective Inhibitors of Urokinase-type Plasminogen Activator with Improved Pharmacokinetic Properties for Use as Antimetastatic Agents
J. Biol. Chem., August 6, 2004; 279(32): 33613 - 33622.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. Li, G. L. Graef, J. A. Yee, and L. Yan
Dietary Supplementation with High-Selenium Soy Protein Reduces Pulmonary Metastasis of Melanoma Cells in Mice
J. Nutr., June 1, 2004; 134(6): 1536 - 1540.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
N. V. Gopee, V. J. Johnson, and R. P. Sharma
Sodium Selenite-Induced Apoptosis in Murine B-Lymphoma Cells Is Associated with Inhibition of Protein Kinase C-{delta}, Nuclear Factor {kappa}B, and Inhibitor of Apoptosis Protein
Toxicol. Sci., April 1, 2004; 78(2): 204 - 214.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. M. Conley, R. L. Bruhn, P. V. Morgan, and W. D. Stamer
Selenium's Effects on MMP-2 and TIMP-1 Secretion by Human Trabecular Meshwork Cells
Invest. Ophthalmol. Vis. Sci., February 1, 2004; 45(2): 473 - 479.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
S. J. Merchant, I. P. Crocker, P. N. Baker, D. Tansinda, S. T. Davidge, and L. J. Guilberg
Matrix Metalloproteinase Release From Placental Explants of Pregnancies Complicated by Intrauterine Growth Restriction
Reproductive Sciences, February 1, 2004; 11(2): 97 - 103.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-C. Lee, Y.-C. Tang, Y.-H. Chen, C.-M. Wong, and A.-P. Tsou
Selenite-induced Survival of HuH7 Hepatoma Cells Involves Activation of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Pathway and Rac1
J. Biol. Chem., October 10, 2003; 278(41): 39615 - 39624.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. K. Nelson, A. C. Ranganathan, J. Mansouri, A. M. Rodriguez, K. M. Providence, J. L. Rutter, K. Pumiglia, J. A. Bennett, and J. A. Melendez
Elevated Sod2 Activity Augments Matrix Metalloproteinase Expression: Evidence for the Involvement of Endogenous Hydrogen Peroxide in Regulating Metastasis
Clin. Cancer Res., January 1, 2003; 9(1): 424 - 432.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement