Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M101790200 on March 30, 2001

J. Biol. Chem., Vol. 276, Issue 24, 21656-21663, June 15, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/24/21656    most recent
M101790200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kleene, R.
Right arrow Articles by Schachner, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kleene, R.
Right arrow Articles by Schachner, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

The Neural Recognition Molecule L1 Is a Sialic Acid-binding Lectin for CD24, Which Induces Promotion and Inhibition of Neurite Outgrowth*

Ralf Kleene, Huibin Yang, Michael Kutsche, and Melitta SchachnerDagger

From the Zentrum für Molekulare Neurobiologie, Universität Hamburg, Martinistr. 52, D-20246 Hamburg, Germany

Among the recognition molecules that determine a neuron's interaction with other cells, L1 and CD24 have been suggested to cooperate with each other in neurite outgrowth and signal transduction. Here we report that binding of CD24 to L1 depends on alpha 2,3-sialic acid on CD24, which determines the CD24 induced and cell type-specific promotion or inhibition of neurite outgrowth. Using knockout mutants, we could show that the CD24-induced effects on neurite outgrowth are mediated via L1, and not GPI-linked CD24, by trans-interaction of L1 with sialylated CD24. This glycoform is excluded together with L1 from raft microdomains, suggesting that molecular compartmentation in the surface membrane could play a role in signal transduction.

* This work was supported by Deutsche Forschungsgemeinschaft Grant Scha 185/27-1, 2.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed. Tel.: 49-40-42803-6246; Fax: 49-40-42803-6248; E-mail: melitta.schachner@zmnh.uni-hamburg.de.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
A. Lieberoth, F. Splittstoesser, N. Katagihallimath, I. Jakovcevski, G. Loers, B. Ranscht, D. Karagogeos, M. Schachner, and R. Kleene
Lewisx and {alpha}2,3-Sialyl Glycans and Their Receptors TAG-1, Contactin, and L1 Mediate CD24-Dependent Neurite Outgrowth
J. Neurosci., May 20, 2009; 29(20): 6677 - 6690.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
V. Ravichandran and E. O. Major
DNA-binding transcription factor NF-1A negatively regulates JC virus multiplication
J. Gen. Virol., June 1, 2008; 89(6): 1396 - 1401.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Chen, J. Wu, I. Apostolova, M. Skup, A. Irintchev, S. Kugler, and M. Schachner
Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury
Brain, April 1, 2007; 130(4): 954 - 969.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Bernreuther, M. Dihne, V. Johann, J. Schiefer, Y. Cui, G. Hargus, J. S. Schmid, J. Xu, C. M. Kosinski, and M. Schachner
Neural Cell Adhesion Molecule L1-Transfected Embryonic Stem Cells Promote Functional Recovery after Excitotoxic Lesion of the Mouse Striatum.
J. Neurosci., November 8, 2006; 26(45): 11532 - 11539.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. K. Altheide, T. Hayakawa, T. S. Mikkelsen, S. Diaz, N. Varki, and A. Varki
System-wide Genomic and Biochemical Comparisons of Sialic Acid Biology Among Primates and Rodents: EVIDENCE FOR TWO MODES OF RAPID EVOLUTION
J. Biol. Chem., September 1, 2006; 281(35): 25689 - 25702.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Baumann, N. Cremers, F. Kroese, G. Orend, R. Chiquet-Ehrismann, T. Uede, H. Yagita, and J. P. Sleeman
CD24 Expression Causes the Acquisition of Multiple Cellular Properties Associated with Tumor Growth and Metastasis
Cancer Res., December 1, 2005; 65(23): 10783 - 10793.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
E. Anderson, S. Maday, J. Sfakianos, M. Hull, B. Winckler, D. Sheff, H. Folsch, and I. Mellman
Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways
J. Cell Biol., August 15, 2005; 170(4): 595 - 605.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Kishi, T. T. Kummer, S. J. Eglen, and J. R. Sanes
LL5{beta}: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction
J. Cell Biol., April 25, 2005; 169(2): 355 - 366.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
Z. Herincs, V. Corset, N. Cahuzac, C. Furne, V. Castellani, A.-O. Hueber, and P. Mehlen
DCC association with lipid rafts is required for netrin-1-mediated axon guidance
J. Cell Sci., April 15, 2005; 118(8): 1687 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
I. Leshchyns'ka, V. Sytnyk, J. S. Morrow, and M. Schachner
Neural cell adhesion molecule (NCAM) association with PKC{beta}2 via {beta}I spectrin is implicated in NCAM-mediated neurite outgrowth
J. Cell Biol., May 12, 2003; 161(3): 625 - 639.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. C. Elliott, M. F. Miles, and D. H. Lowenstein
Overlapping Microarray Profiles of Dentate Gyrus Gene Expression during Development- and Epilepsy-Associated Neurogenesis and Axon Outgrowth
J. Neurosci., March 15, 2003; 23(6): 2218 - 2227.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Kalus, B. Schnegelsberg, N. G. Seidah, R. Kleene, and M. Schachner
The Proprotein Convertase PC5A and a Metalloprotease Are Involved in the Proteolytic Processing of the Neural Adhesion Molecule L1
J. Biol. Chem., March 14, 2003; 278(12): 10381 - 10388.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
T. Sasaki, Y. Akimoto, Y. Sato, H. Kawakami, H. Hirano, and T. Endo
Distribution of Sialoglycoconjugates in the Rat Cerebellum and Its Change with Aging
J. Histochem. Cytochem., September 1, 2002; 50(9): 1179 - 1186.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement