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J. Biol. Chem., Vol. 276, Issue 25, 22011-22015, June 22, 2001
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From the Department of Biochemistry, The Institute of Medical
Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639
Japan
We have characterized a novel Sac
domain-containing inositol phosphatase, hSac2. It was ubiquitously
expressed but especially abundant in the brain, heart, skeletal muscle,
and kidney. Unlike other Sac domain-containing proteins, hSac2 protein
exhibited 5-phosphatase activity specific for phosphatidylinositol
4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate.
This is the first time that the Sac domain has been reported to possess
5-phosphatase activity. Its 5-phosphatase activity for
phosphatidylinositol 4,5-bisphosphate (Km = 14.3 µM) was comparable with those of Type II
5-phosphatases. These results imply that hSac2 functions as an inositol
polyphosphate 5-phosphatase.
Identification and Characterization of a Sac Domain-containing
Phosphoinositide 5-Phosphatase*
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Dept. of Biochemistry,
The Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639 Japan. Tel: 81-3-5449-5510; Fax: 81-3-5449-5417; E-mail: takenawa@ims.u-tokyo.ac.jp.
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