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J. Biol. Chem., Vol. 276, Issue 26, 23992-23999, June 29, 2001
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From the Institute of Medical Science and Department of Laboratory
Medicine and Pathobiology, University of Toronto, Toronto,
Ontario M5G 1L5, Canada
The RING domain is a conserved zinc finger motif,
which serves as a protein-protein interaction interface. Searches of a
human heart expressed sequence tag data base for genes encoding the RING domain identified a novel cDNA, named striated muscle RING zinc finger protein (SMRZ). The SMRZ cDNA is 1.9 kilobase pairs in
length and encodes a polypeptide of 288 amino acid residues; analysis
of the peptide sequence demonstrated an N-terminal RING domain.
Fluorescence in situ hybridization localized SMRZ to
chromosome 1p33-34. Northern blots demonstrated that SMRZ is expressed
exclusively in striated muscle. In the cardiovascular system, SMRZ is
more highly expressed in the fetal heart than in the adult heart
(slightly higher expression in the ventricle than in the atrium),
suggesting that SMRZ is developmentally regulated. SMRZ was found to
interact with SMT3b, a ubiquitin-like protein, through the SMRZ-RING
domain. This interaction was abolished by mutagenesis of conserved RING domain residues. Transient transfection of SMRZ into C2C12 myoblasts showed localization of SMRZ to the nucleus. These data suggest that
SMRZ may play an important role in striated muscle cell embryonic development and perhaps in cell cycle regulation.
A Novel Human Striated Muscle RING Zinc Finger
Protein, SMRZ, Interacts with SMT3b via Its RING Domain*
and
*
This work was supported in part by the Medical Research
Council of Canada, the Heart and Stroke Foundation of Ontario, and the
Canadian Genome Analysis and Technology Program.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Recipient of a Heart and Stroke Foundation traineeship.
§
To whom correspondence should be addressed: Cardiovascular Genome
Unit, Brigham and Women's Hospital, Harvard Medical School, 75 Francis
St., Thorn 1326, Boston, MA 02115. Tel.: 617-732-8117; Fax:
617-975-0995; E-mail: liewcc@tcgu.med.utoronto.ca.
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