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J. Biol. Chem., Vol. 276, Issue 26, 24360-24364, June 29, 2001
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From the Human alveolar macrophages (A-M
Human Alveolar Macrophages and Granulocyte-macrophage
Colony-stimulating Factor-induced Monocyte-derived Macrophages Are
Resistant to H2O2 via Their High Basal and
Inducible Levels of Catalase Activity*
§,¶,
Department of Immunology, National Institute
of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, the § Division of Infectious Diseases, the Advanced Clinical
Research Center, Institute of Medical Science, University of Tokyo,
Shiroganedai 4-6-1, Minato-ku, Tokyo 108-8639, and the
¶ Department of Respiratory Medicine, University of Tokyo, Hongo
7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan
) and
macrophages (M) generated from human monocytes under the
influence of granulocyte-macrophage colony-stimulating factors
(GM-M) express high levels of catalase activity and are
highly resistant to H2O2. In contrast,
M generated from monocytes by macrophage colony-stimulating factors
(M-M) express low catalase activity and are about 50-fold more
sensitive to H2O2 than GM-M or A-M. Both
A-M and GM-M but not M-M can induce catalase expression in
both protein and mRNA levels when stimulated with
H2O2 or zymosan. M-M but not GM-M produce
a large amount of H2O2 in response to zymosan
or heat-killed Staphylococcus aureus. These findings
indicate that GM-M and A-M but not M-M are strong scavengers
of H2O2 via the high basal level of
catalase activity and a marked ability of catalase induction and that
catalase activity of M is regulated by colony-stimulating
factors during differentiation.
*
This study was supported in part by grants from the Japan
Health Science Foundation and the Ministry of Health and Welfare of
Japan (to K. S. A.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.:
81-3-5285-1111; Fax: 81-3-5285-1150; E-mail: akagawak@nih.go.jp.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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