|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 276, Issue 27, 25287-25293, July 6, 2001
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the High density lipoprotein (HDL) mediates reverse
transport of cholesterol from atheroma foam cells to the liver, but the
mechanisms of hepatic uptake and trafficking of HDL particles are
poorly understood. In contrast to its accepted role as a cell surface receptor, scavenger receptor class B type 1 (SR-BI) is shown to be an
endocytic receptor that mediates HDL particle uptake and recycling, but
not degradation, in both transfected Chinese hamster ovary cells and
hepatocytes. Confocal microscopy of polarized primary
hepatocytes shows that HDL particles enter both the endocytic recycling
compartment and the apical canalicular region paralleling the movement
of SR-BI. In polarized epithelial cells (Madin-Darby canine kidney)
expressing SR-BI, HDL protein and cholesterol undergo selective sorting
with recycling of HDL protein from the basolateral membrane and
secretion of HDL-derived cholesterol through the apical membrane. Thus,
HDL particles, internalized via SR-BI, undergo a novel process of
selective transcytosis, leading to polarized cholesterol transport. A
distinct process not mediated by SR-BI is involved in uptake and
degradation of apoE-free HDL in hepatocytes.
High Density Lipoprotein (HDL) Particle Uptake Mediated by
Scavenger Receptor Class B Type 1 Results in Selective Sorting of HDL
Cholesterol from Protein and Polarized Cholesterol
Secretion*
§,,
Department of Medicine, Division of
Molecular Medicine, Columbia University, New York, New York 10032 and
the ¶ Department of Molecular Genetics and Biochemistry,
University of Pittsburgh, Pittsburgh, Pennsylvania 15219
*
This work was supported by National Institutes of Health
Grant HL22682 (to A. R. T.) and National Institutes of Health
Research Fellowship Award HL09928 (to D. L. S.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Xiao, T. Watanabe, Y. Zhang, B. Trigatti, L. Szeto, P. W. Connelly, S. Marcovina, T. Vaisar, J. W. Heinecke, and G. F. Lewis Enhanced Cellular Uptake of Remnant High-Density Lipoprotein Particles: A Mechanism for High-Density Lipoprotein Lowering in Insulin Resistance and Hypertriglyceridemia Circ. Res., July 18, 2008; 103(2): 159 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ahras, T. Naing, and R. McPherson Scavenger receptor class B type I localizes to a late endosomal compartment J. Lipid Res., July 1, 2008; 49(7): 1569 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Yang, C. Qiu, N. Biswas, J. Jin, S. C. Watkins, R. C. Montelaro, C. B. Coyne, and T. Wang Correlation of the Tight Junction-like Distribution of Claudin-1 to the Cellular Tropism of Hepatitis C Virus J. Biol. Chem., March 28, 2008; 283(13): 8643 - 8653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Minahk, K.-W. Kim, R. Nelson, B. Trigatti, R. Lehner, and D. E. Vance Conversion of Low Density Lipoprotein-associated Phosphatidylcholine to Triacylglycerol by Primary Hepatocytes J. Biol. Chem., March 7, 2008; 283(10): 6449 - 6458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Eck, M. Hoekstra, R. Out, I. S. T. Bos, J. K. Kruijt, R. B. Hildebrand, and T. J. C. Van Berkel Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo J. Lipid Res., January 1, 2008; 49(1): 136 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sun, B. B. Boyanovsky, M. A. Connelly, P. Shridas, D. R. van der Westhuyzen, and N. R. Webb Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI J. Lipid Res., December 1, 2007; 48(12): 2560 - 2570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Pagler, A. Neuhofer, H. Laggner, W. Strobl, and H. Stangl Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaired J. Lipid Res., October 1, 2007; 48(10): 2141 - 2150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Tellinghuisen, M. J. Evans, T. von Hahn, S. You, and C. M. Rice Studying Hepatitis C Virus: Making the Best of a Bad Virus J. Virol., September 1, 2007; 81(17): 8853 - 8867. [Full Text] [PDF]
|
|
|
|
|
|
M. T. Catanese, R. Graziani, T. von Hahn, M. Moreau, T. Huby, G. Paonessa, C. Santini, A. Luzzago, C. M. Rice, R. Cortese, et al. High-Avidity Monoclonal Antibodies against the Human Scavenger Class B Type I Receptor Efficiently Block Hepatitis C Virus Infection in the Presence of High-Density Lipoprotein J. Virol., August 1, 2007; 81(15): 8063 - 8071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Yancey, W. G. Jerome, H. Yu, E. E. Griffin, B. E. Cox, V. R. Babaev, S. Fazio, and M. F. Linton Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI J. Lipid Res., May 1, 2007; 48(5): 1140 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, A. M. Ahmed, N. McFarlane, C. Capone, D. R. Boreham, R. Truant, S. A. Igdoura, and B. L. Trigatti Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways J. Lipid Res., February 1, 2007; 48(2): 405 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Harder, A. Meng, P. Rippstein, H. M. McBride, and R. McPherson SR-BI Undergoes Cholesterol-stimulated Transcytosis to the Bile Canaliculus in Polarized WIF-B Cells J. Biol. Chem., January 12, 2007; 282(2): 1445 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Pagler, S. Golsabahi, M. Doringer, S. Rhode, G. J. Schutz, M. Pavelka, C. Wadsack, M. Gauster, A. Lohninger, H. Laggner, et al. A Chinese Hamster Ovarian Cell Line Imports Cholesterol by High Density Lipoprotein Degradation J. Biol. Chem., December 15, 2006; 281(50): 38159 - 38171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Florvall, S. Basu, and A. Larsson Apolipoprotein A1 Is a Stronger Prognostic Marker Than Are HDL and LDL Cholesterol for Cardiovascular Disease and Mortality in Elderly Men J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2006; 61(12): 1262 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ikonen Mechanisms for cellular cholesterol transport: defects and human disease. Physiol Rev, October 1, 2006; 86(4): 1237 - 1261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shetty, E. R.M. Eckhardt, S. R. Post, and D. R. van der Westhuyzen Phosphatidylinositol-3-Kinase Regulates Scavenger Receptor Class B Type I Subcellular Localization and Selective Lipid Uptake in Hepatocytes Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 2125 - 2131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sun, E. R. M. Eckhardt, S. Shetty, D. R. van der Westhuyzen, and N. R. Webb Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts J. Lipid Res., August 1, 2006; 47(8): 1700 - 1713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Braun, P. J. Mohler, K. H. Weisgraber, A. H. Hasty, M. F. Linton, P. G. Yancey, Y. R. Su, S. Fazio, and L. L. Swift Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells J. Lipid Res., June 1, 2006; 47(6): 1176 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Smith Insight Into ABCG1-Mediated Cholesterol Efflux. Arterioscler. Thromb. Vasc. Biol., June 1, 2006; 26(6): 1198 - 1200. [Full Text] [PDF]
|
|
|
|
|
|
C. Xie, J. A. Richardson, S. D. Turley, and J. M. Dietschy Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein J. Lipid Res., May 1, 2006; 47(5): 953 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Pagler, S. Rhode, A. Neuhofer, H. Laggner, W. Strobl, C. Hinterndorfer, I. Volf, M. Pavelka, E. R. M. Eckhardt, D. R. van der Westhuyzen, et al. SR-BI-mediated High Density Lipoprotein (HDL) Endocytosis Leads to HDL Resecretion Facilitating Cholesterol Efflux J. Biol. Chem., April 21, 2006; 281(16): 11193 - 11204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Harder, G. Vassiliou, H. M. McBride, and R. McPherson Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy J. Lipid Res., March 1, 2006; 47(3): 492 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. M. Eckhardt, L. Cai, S. Shetty, Z. Zhao, A. Szanto, N. R. Webb, and D. R. Van der Westhuyzen High Density Lipoprotein Endocytosis by Scavenger Receptor SR-BII Is Clathrin-dependent and Requires a Carboxyl-terminal Dileucine Motif J. Biol. Chem., February 17, 2006; 281(7): 4348 - 4353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lan and D. L. Silver Fenofibrate Induces a Novel Degradation Pathway for Scavenger Receptor B-I Independent of PDZK1 J. Biol. Chem., June 17, 2005; 280(24): 23390 - 23396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wustner Mathematical Analysis of Hepatic High Density Lipoprotein Transport Based on Quantitative Imaging Data J. Biol. Chem., February 25, 2005; 280(8): 6766 - 6779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cai, M. C. de Beer, F. C. de Beer, and D. R. van der Westhuyzen Serum Amyloid A Is a Ligand for Scavenger Receptor Class B Type I and Inhibits High Density Lipoprotein Binding and Selective Lipid Uptake J. Biol. Chem., January 28, 2005; 280(4): 2954 - 2961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C.D. van IJzendoorn, J. M. van der Wouden, G. Liebisch, G. Schmitz, and D. Hoekstra Polarized Membrane Traffic and Cell Polarity Development Is Dependent on Dihydroceramide Synthase-Regulated Sphinganine Turnover Mol. Biol. Cell, September 1, 2004; 15(9): 4115 - 4124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Rhainds, P. Bourgeois, G. Bourret, K. Huard, L. Falstrault, and L. Brissette Localization and regulation of SR-BI in membrane rafts of HepG2 cells J. Cell Sci., July 1, 2004; 117(15): 3095 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Camarota, J. M. Chapman, D. Y. Hui, and P. N. Howles Carboxyl Ester Lipase Cofractionates with Scavenger Receptor BI in Hepatocyte Lipid Rafts and Enhances Selective Uptake and Hydrolysis of Cholesteryl Esters from HDL3 J. Biol. Chem., June 25, 2004; 279(26): 27599 - 27606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Drew, N. H. Fidge, G. Gallon-Beaumier, B. E. Kemp, and B. A. Kingwell High-density lipoprotein and apolipoprotein AI increase endothelial NO synthase activity by protein association and multisite phosphorylation PNAS, May 4, 2004; 101(18): 6999 - 7004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. M. Eckhardt, L. Cai, B. Sun, N. R. Webb, and D. R. van der Westhuyzen High Density Lipoprotein Uptake by Scavenger Receptor SR-BII J. Biol. Chem., April 2, 2004; 279(14): 14372 - 14381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Burgos, C. Klattenhoff, E. de la Fuente, A. Rigotti, and A. Gonzalez Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells PNAS, March 16, 2004; 101(11): 3845 - 3850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wustner, M. Mondal, A. Huang, and F. R. Maxfield Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells J. Lipid Res., March 1, 2004; 45(3): 427 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cai, E. R. M. Eckhardt, W. Shi, Z. Zhao, M. Nasser, W. J. S. de Villiers, and D. R. van der Westhuyzen Scavenger receptor class B type I reduces cholesterol absorption in cultured enterocyte CaCo-2 cells J. Lipid Res., February 1, 2004; 45(2): 253 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fu, K. F. Kozarsky, and J. Borensztajn Overexpression of SR-BI by Adenoviral Vector Reverses the Fibrateinduced Hypercholesterolemia of Apolipoprotein E-deficient Mice J. Biol. Chem., December 26, 2003; 278(52): 52559 - 52563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G H Hansen, L-L Niels-Christiansen, L Immerdal, and E M Danielsen Scavenger receptor class B type I (SR-BI) in pig enterocytes: trafficking from the brush border to lipid droplets during fat absorption Gut, October 1, 2003; 52(10): 1424 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Trigatti, M. Krieger, and A. Rigotti Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., October 1, 2003; 23(10): 1732 - 1738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Sehayek, R. Wang, J. G. Ono, V. S. Zinchuk, E. M. Duncan, S. Shefer, D. E. Vance, M. Ananthanarayanan, B. T. Chait, and J. L. Breslow Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol J. Lipid Res., September 1, 2003; 44(9): 1605 - 1613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. TUMA and A. L. HUBBARD Transcytosis: Crossing Cellular Barriers Physiol Rev, July 1, 2003; 83(3): 871 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Eck, J. Twisk, M. Hoekstra, B. T. Van Rij, C. A. C. Van der Lans, I. S. T. Bos, J. K. Kruijt, F. Kuipers, and T. J. C. Van Berkel Differential Effects of Scavenger Receptor BI Deficiency on Lipid Metabolism in Cells of the Arterial Wall and in the Liver J. Biol. Chem., June 20, 2003; 278(26): 23699 - 23705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Vishnyakova, A. V. Bocharov, I. N. Baranova, Z. Chen, A. T. Remaley, G. Csako, T. L. Eggerman, and A. P. Patterson Binding and Internalization of Lipopolysaccharide by Cla-1, a Human Orthologue of Rodent Scavenger Receptor B1 J. Biol. Chem., June 13, 2003; 278(25): 22771 - 22780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rigotti, H. E. Miettinen, and M. Krieger The Role of the High-Density Lipoprotein Receptor SR-BI in the Lipid Metabolism of Endocrine and Other Tissues Endocr. Rev., June 1, 2003; 24(3): 357 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heeren, T. Grewal, A. Laatsch, D. Rottke, F. Rinninger, C. Enrich, and U. Beisiegel Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization J. Biol. Chem., April 11, 2003; 278(16): 14370 - 14378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Panzenboeck, Z. Balazs, A. Sovic, A. Hrzenjak, S. Levak-Frank, A. Wintersperger, E. Malle, and W. Sattler ABCA1 and Scavenger Receptor Class B, Type I, Are Modulators of Reverse Sterol Transport at an in Vitro Blood-Brain Barrier Constituted of Porcine Brain Capillary Endothelial Cells J. Biol. Chem., November 1, 2002; 277(45): 42781 - 42789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Silver A Carboxyl-terminal PDZ-interacting Domain of Scavenger Receptor B, Type I Is Essential for Cell Surface Expression in Liver J. Biol. Chem., September 6, 2002; 277(37): 34042 - 34047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Liu and M. Krieger Highly Purified Scavenger Receptor Class B, Type I Reconstituted into Phosphatidylcholine/Cholesterol Liposomes Mediates High Affinity High Density Lipoprotein Binding and Selective Lipid Uptake J. Biol. Chem., September 6, 2002; 277(37): 34125 - 34135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Fitzgerald, A. L. Morris, J. S. Rhee, L. P. Andersson, A. J. Mendez, and M. W. Freeman Naturally Occurring Mutations in the Largest Extracellular Loops of ABCA1 Can Disrupt Its Direct Interaction with Apolipoprotein A-I J. Biol. Chem., August 30, 2002; 277(36): 33178 - 33187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wustner, A. Herrmann, M. Hao, and F. R. Maxfield Rapid Nonvesicular Transport of Sterol between the Plasma Membrane Domains of Polarized Hepatic Cells J. Biol. Chem., August 9, 2002; 277(33): 30325 - 30336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Goti, Z. Balazs, U. Panzenboeck, A. Hrzenjak, H. Reicher, E. Wagner, R. Zechner, E. Malle, and W. Sattler Effects of Lipoprotein Lipase on Uptake and Transcytosis of Low Density Lipoprotein (LDL) and LDL-associated alpha -Tocopherol in a Porcine in Vitro Blood-Brain Barrier Model J. Biol. Chem., August 2, 2002; 277(32): 28537 - 28544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Wade, R. A. Van Andel, S. G. Rice, C. L. Banka, and C. A. Dyer Hepatic Lipase Deficiency Attenuates Mouse Ovarian Progesterone Production Leading to Decreased Ovulation and Reduced Litter Size Biol Reprod, April 1, 2002; 66(4): 1076 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, Y. Sun, C. Welch, A. Gorelik, A. R. Leventhal, I. Tabas, and A. R. Tall Preferential ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux from Late Endosomes/Lysosomes J. Biol. Chem., November 16, 2001; 276(47): 43564 - 43569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Thuahnai, S. Lund-Katz, D. L. Williams, and M. C. Phillips Scavenger Receptor Class B, Type I-mediated Uptake of Various Lipids into Cells. INFLUENCE OF THE NATURE OF THE DONOR PARTICLE INTERACTION WITH THE RECEPTOR J. Biol. Chem., November 16, 2001; 276(47): 43801 - 43808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Attie, J. P. Kastelein, and M. R. Hayden Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis J. Lipid Res., November 1, 2001; 42(11): 1717 - 1726. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |