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J. Biol. Chem., Vol. 276, Issue 28, 25651-25653, July 13, 2001
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Agonists*
§,,,,,, and
From Elevated levels of the hormone resistin, which is
secreted by fat cells, are proposed to cause insulin resistance and to
serve as a link between obesity and type 2 diabetes. In this report we
show that resistin expression is significantly decreased in the white
adipose tissue of several different models of obesity including the
ob/ob, db/db, tub/tub, and KKAy mice compared
with their lean counterparts. Furthermore, in response to several
different classes of antidiabetic peroxisome proliferator-activated receptor GlaxoSmithKline Research and Development,
Research Triangle Park, North Carolina 27709 and ¶ Division of
Biological Sciences and Department of Nutrition, Harvard School of
Public Health, Boston, Massachusetts 02115
agonists, adipose tissue resistin expression is
increased in both ob/ob mice and Zucker diabetic fatty rats. These data demonstrate that experimental obesity in rodents is associated with
severely defective resistin expression, and decreases in resistin
expression are not required for the antidiabetic actions of
peroxisome proliferator-activated receptor agonists.
To whom correspondence should be addressed: Harvard School of
Public Health, 665 Huntington Ave., Boston, MA 02115. Tel.: 617-432-1950; Fax: 617-432-1941; E-mail:
ghotamis@hsph.harvard.edu.
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