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J. Biol. Chem., Vol. 276, Issue 28, 26374-26383, July 13, 2001
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From Antisense box C/D small nucleolar RNAs (snoRNAs)
guide the 2'-O-ribose methylations of eukaryotic rRNAs and
small nuclear RNAs (snRNAs) through formation of a specific base
pairing at each RNA methylation site. By analysis of a box C/D snoRNA
cDNA library constructed from rat brain RNAs, we have identified a novel box C/D snoRNA, RBII-36, which is devoid of complementarity to
rRNA or an snRNA and exhibits a brain-specific expression pattern. It
is uniformly expressed in all major areas of adult rat brain (except
for choroid plexus) and throughout rat brain ontogeny but exclusively
detected in neurons in which it exhibits a nucleolar localization. In
vertebrates, known methylation guide snoRNAs are intron-encoded and
processed from transcripts of housekeeping genes. In contrast, RBII-36
snoRNA is intron-encoded in a gene preferentially expressed in the rat
central nervous system and not in proliferating cells. Remarkably, this
host gene, which encodes a previously reported noncoding RNA, Bsr,
spans tandemly repeated 0.9-kilobase units including the
snoRNA-containing intron. The novel brain-specific snoRNA appears to
result not only from processing of the debranched lariat but also from
endonucleolytic cleavages of unspliced Bsr RNA (i.e. an
alternative splicing-independent pathway unreported so far for
mammalian intronic snoRNAs). Sequences homologous to RBII-36 snoRNA
were exclusively detected in the Rattus genus of rodents,
suggesting a very recent origin of this brain-specific snoRNA.
A Novel Brain-specific Box C/D Small Nucleolar RNA Processed from
Tandemly Repeated Introns of a Noncoding RNA Gene in Rats*
§,,
, and**
UMR5099, Laboratoire de Biologie
Moléculaire Eucaryote du Centre National de la Recherche
Scientifique, Université Paul-Sabatier, 118 route de Narbonne,
Toulouse 31062, France, ¶ UPR 9023 CNRS, Mécanismes
Moléculaires des Communications Cellulaires, 34094 Montpellier
Cedex 05, France, and Institute for Experimental Pathology,
Zentrum für Molekulare Biologie der Entzündung, 48149 Münster, Germany
*
This work was supported by a grant from the Association pour
la Recherche sur le Cancer (to J. P. B.), by laboratory funds from
the Center National de la Recherche Scientifique and Université Paul-Sabatier, Toulouse, and by the German Human Genome Project through
Bundesministerium für Bildung, Wissenschaft, Forschung Grant 01KW9966 and an Interdisziplinäres Zentrum für
Klinische Forschung grant (Teilprojekt F3, Münster) (to A. H.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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