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J. Biol. Chem., Vol. 276, Issue 29, 26955-26961, July 20, 2001
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From the Bristol Centre for Antimicrobial Research and Evaluation,
Department of Pathology and Microbiology, School of Medical Sciences,
University of Bristol, University Walk, Bristol, BS8 1TD, United
Kingdom
We have identified nine genes, the expression of
which are regulated by the CreBC two-component system: the first
members of the cre regulon. They are divided into eight transcriptional units, each having a promoter-proximal TTCACnnnnnnTTCAC "cre-tag" motif. The cre regulon genes are: the
ackA/pta operon, the products of which
collectively catalyze the conversion of acetyl-CoA into acetate and
ATP; talA, which encodes an enzyme involved in the mobilization of glyceraldehyde-3-phosphate into the pentose phosphate pathway; radC, which encodes a RecG-like DNA
recombination/repair function; malE, which is the first
gene in the malEFG maltose transporter operon;
trgB, which encodes an ADP-ribose pyrophosphorylase; and
three other genes, creD, yidS and
yieI, the products of which have not been assigned a
function. Expression of each of these cre regulon genes is induced via
CreBC during growth in minimal media, with the exception of
malE, which is more tightly repressed. The diverse
functions encoded by the cre regulon suggest that CreBC is a
global regulator that sits right at the heart of metabolic control in
Escherichia coli.
Escherichia coli CreBC Is a Global Regulator of Gene
Expression That Responds to Growth in Minimal Media*
,
*
This work was supported by grants from the Wellcome Trust.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed at present address:
Dept. of Biochemistry, School of Medical Sciences, Univ. of Bristol,
University Walk, Bristol, BS8 1TD, United Kingdom. Tel.: 44-117-9287439; Fax: 44-117-9288274; E-mail:
Matthewb.Avison@bris.ac.uk.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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