| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 276, Issue 29, 27647-27656, July 20, 2001
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the In this report, we explore the mechanisms
of targeting of p300 to the interleukin-2 (IL-2) promoter in response
to mitogenic and oncogenic molecular signals. Recruitment of p300 by
cAMP-responsive element-binding protein-Rel cross-talk at the composite
CD28 response element (CD28RE)-TRE element of the IL-2 promoter is
essential for promoter inducibility during T-cell activation, and
CD28RE-TRE is the exclusive target of the human T-cell lymphotropic
virus type I oncoprotein Tax. The intrinsic histone acetyltransferase activity of p300 is dispensable for activation of the IL-2 promoter, and the N-terminal 743 residues contain the minimal structural requirements for synergistic transactivation of the CD28RE-TRE, the
IL-2 promoter, and endogenous IL-2 gene expression. Mutational analysis
of p300 reveals differential structural requirements for the N-terminal
p300 module by individual cis-elements within the IL-2 promoter. These
findings provide evidence that p300 assembles at the IL-2 promoter to
form an enhanceosome-like signal transduction target that is centrally
integrated at the CD28RE-TRE element of the IL-2 promoter through
specific protein module-targeted associations in activated T-cells.
Targeting of p300 to the Interleukin-2 Promoter via
CREB-Rel Cross-talk during Mitogen and Oncogenic Molecular
Signaling in Activated T-cells*
,,§, and¶
Advanced Technology Center, Laboratory of
Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892 and the § Department of Microbiology, Howard University
College of Medicine, Washington, D. C. 20059
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  R. M. Thomas, N. Chunder, C. Chen, S. E. Umetsu, S. Winandy, and A. D. Wells Ikaros Enforces the Costimulatory Requirement for IL2 Gene Expression and Is Required for Anergy Induction in CD4+ T Lymphocytes J. Immunol., December 1, 2007; 179(11): 7305 - 7315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bostik, E. S. Noble, S. T. Stephenson, F. Villinger, and A. A. Ansari CD4+ T Cells from Simian Immunodeficiency Virus Disease-Resistant Sooty Mangabeys Produce More IL-2 Than Cells from Disease-Susceptible Species: Involvement of p300 and CREB at the Proximal IL-2 Promoter in IL-2 Up-Regulation J. Immunol., June 15, 2007; 178(12): 7720 - 7729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Rowell, L. Wang, W. W. Hancock, and A. D. Wells The Cyclin-Dependent Kinase Inhibitor p27kip1 Is Required for Transplantation Tolerance Induced by Costimulatory Blockade J. Immunol., October 15, 2006; 177(8): 5169 - 5176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. B. Cismasiu, S. Ghanta, J. Duque, D. I. Albu, H.-M. Chen, R. Kasturi, and D. Avram BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes Blood, October 15, 2006; 108(8): 2695 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Nandiwada, W. Li, R. Zhang, and D. L. Mueller p300/Cyclic AMP-Responsive Element Binding-Binding Protein Mediates Transcriptional Coactivation by the CD28 T Cell Costimulatory Receptor J. Immunol., July 1, 2006; 177(1): 401 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Thomas, L. Gao, and A. D. Wells Signals from CD28 Induce Stable Epigenetic Modification of the IL-2 Promoter J. Immunol., April 15, 2005; 174(8): 4639 - 4646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Smith, I. Collins, G. V. R. Chandramouli, W. G. Butscher, E. Zaitseva, W. J. Freebern, C. M. Haggerty, V. Doseeva, and K. Gardner Targeting Combinatorial Transcriptional Complex Assembly at Specific Modules within the Interleukin-2 Promoter by the Immunosuppressant SB203580 J. Biol. Chem., October 17, 2003; 278(42): 41034 - 41046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tenbrock, Y.-T. Juang, M. Tolnay, and G. C. Tsokos The Cyclic Adenosine 5'-Monophosphate Response Element Modulator Suppresses IL-2 Production in Stimulated T Cells by a Chromatin-Dependent Mechanism J. Immunol., March 15, 2003; 170(6): 2971 - 2976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rodriguez-Melendez, G. Camporeale, J. B. Griffin, and J. Zempleni Interleukin-2 receptor-gamma -dependent endocytosis depends on biotin in Jurkat cells Am J Physiol Cell Physiol, February 1, 2003; 284(2): C415 - C421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Freebern, J. L. Smith, S. S. Chaudhry, C. M. Haggerty, and K. Gardner Novel Cell-specific and Dominant Negative Anti-apoptotic Roles of p73 in Transformed Leukemia Cells J. Biol. Chem., January 17, 2003; 278(4): 2249 - 2255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chaudhry, W. J. Freebern, J. L. Smith, W. G. Butscher, C. M. Haggerty, and K. Gardner Cross-Regulation of T Cell Growth Factor Expression by p53 and the Tax Oncogene J. Immunol., December 15, 2002; 169(12): 6767 - 6778. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
