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Originally published In Press as doi:10.1074/jbc.C100222200 on June 4, 2001

J. Biol. Chem., Vol. 276, Issue 30, 27745-27748, July 27, 2001
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ACCELERATED PUBLICATION
Islet-Brain1/JNK-interacting Protein-1 Is Required for Early Embryogenesis in Mice*

Nancy A. ThompsonDagger §, Jacques-Antoine HaefligerDagger §, Alfred Senn||, Thomas TawadrosDagger , Fulvio MagaraDagger , Birgit Ledermann**, Pascal NicodDagger , and Gérard WaeberDagger Dagger Dagger

From the Dagger  Department of Internal Medicine and Institute of Cellular Biology and Morphology and the || Reproductive Medicine Unit, Department of Obstetrics and Gynecology, CHUV-University Hospital, 1011 Lausanne and the ** Labortierkunde, University of Zürich, 8057 Zürich, Switzerland

Islet-brain1/JNK-interacting protein-1 (IB1/JIP-1) is a scaffold protein that organizes the JNK, MKK7, and MLK1 to allow signaling specificity. Targeted disruption of the gene MAPK8IP1 encoding IB1/JIP-1 in mice led to embryonic death prior to blastocyst implantation. In culture, no IB1/JIP-1-/- embryos were identified indicating that accelerated cell death occurred during the first cell cycles. IB1/JIP-1 expression was detected in unfertilized oocytes, in spermatozoa, and in different stages of embryo development. Thus, despite the maternal and paternal transmission of the IB1/JIP-1 protein, early transcription of the MAPK8IP1 gene is required for the survival of the fertilized oocytes.

* This work was supported in part by Swiss National Science Foundation Grants 32-48916.96 and 32-54119.98 (to G. W.) and 31-56689.99 (to J. A. H.) and by the Placide Nicod and Octav and Marcella Botnar Foundation.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ Contributed equally to the work.

Present addess: ISREC 1010 Epalinges, Switzerland.

Dagger Dagger To whom correspondence should be addressed: Dept. of Internal Medicine B, CHUV-University Hospital, 1011 Lausanne, Switzerland. Tel.: 41-21-314-09-60; Fax: 41-21-314-09-68; E-mail: gwaeber@chuv.hospvd.ch.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.


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