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J. Biol. Chem., Vol. 276, Issue 33, 31016-31022, August 17, 2001
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From the Department of Biological Sciences, Korea Advanced
Institute of Science and Technology, Daejeon 305-701, Korea
A multifunctional transcription co-activator,
cAMP response element-binding protein-binding protein
(CBP)interacts with a number of cellular factors and participates
in cell growth, transformation, and development. It is also targeted by
many viral proteins for their transcriptional activity or for the
regulation of cellular processes. Here, we report that the C/H3 region
of CBP is targeted by the latency associated nuclear antigen (LANA) of
Kaposi's sarcoma-associated herpesvirus (KSHV). LANA interferes with
the interaction between CBP and c-Fos, a representative C/H3 region
binding, cellular transcription factor, in vivo and
in vitro. In addition, we found that LANA inhibits the
transcriptional activity and the in vitro histone
acetyltransferase activity of CBP, suggesting that LANA modulates the global transcriptional activities of infected cells through the interaction with CBP. These results indicate that KSHV
follows one of the conserved strategies, which other viruses utilize
for influencing the cellular processes.
To whom correspondence should be addressed. Tel.: 82-42-869-2630;
Fax: 82-42-869-5630; E-mail: jchoe@mail.kaist.ac.kr.
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