|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 276, Issue 36, 33747-33754, September 7, 2001
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Medical Science Division, Fox Chase Cancer Center,
Philadelphia, Pennsylvania 19111
Human multidrug resistance protein 4 (MRP4) has
recently been determined to confer resistance to the antiviral purine
analog 9-(2-phosphonylmethoxyethyl)adenine and methotrexate. However, neither its substrate selectivity nor physiological functions have been
determined. Here we report the results of investigations of the
in vitro transport properties of MRP4 using membrane
vesicles prepared from insect cells infected with MRP4 baculovirus. It is shown that expression of MRP4 is specifically associated with the
MgATP-dependent transport of cGMP, cAMP, and
estradiol 17-
Transport of Cyclic Nucleotides and Estradiol
17-
-D-Glucuronide by Multidrug Resistance Protein 4
RESISTANCE TO 6-MERCAPTOPURINE AND 6-THIOGUANINE*
§,¶, and
-D-glucuronide (E217G).
cGMP, cAMP, and E217G are transported with
Km and Vmax values of
9.7 ± 2.3 µM and 2.0 ± 0.3 pmol/mg/min,
44.5 ± 5.8 µM and 4.1 ± 0.4 pmol/mg/min, and
30.3 ± 6.2 µM and 102 ± 16 pmol/mg/min,
respectively. Consistent with its ability to transport cyclic
nucleotides, it is demonstrated that the MRP4 drug resistance profile
extends to 6-mercaptopurine and 6-thioguanine, two anticancer purine
analogs that are converted in the cell to nucleotide analogs. On the
basis of its capacity to transport cyclic nucleotides and
E217G, it is concluded that MRP4 may influence diverse
cellular processes regulated by cAMP and cGMP and that its substrate
range is distinct from that of any other characterized MRP family member.
*
This work was supported in part by National Institutes of
Health Grant CA73728 (to G. D. K.) and by an appropriation from the
Commonwealth of Pennsylvania.The costs of publication of this article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Contributed equally to this work.
§
Recipient of a Japan Research Foundation for Clinical Pharmacology award.
¶
Recipient of National Institutes of Health Fellowship CA74518.
To whom correspondence should be addressed: Fox Chase Cancer
Center, 7701 Burholme Ave., Philadelphia, PA 19111. Tel.: 215-728-5317; Fax: 215-728-3603; E-mail: GD_Kruh@fccc.edu.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Guo, K. Kock, C. A. Ritter, Z.-S. Chen, M. Grube, G. Jedlitschky, T. Illmer, M. Ayres, J. F. Beck, W. Siegmund, et al. Expression of ABCC-Type Nucleotide Exporters in Blasts of Adult Acute Myeloid Leukemia: Relation to Long-term Survival Clin. Cancer Res., March 1, 2009; 15(5): 1762 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Aleksunes, Y. Cui, and C. D. Klaassen Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta Drug Metab. Dispos., September 1, 2008; 36(9): 1960 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. de Wolf, R. Jansen, H. Yamaguchi, M. de Haas, K. van de Wetering, J. Wijnholds, J. Beijnen, and P. Borst Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides Mol. Cancer Ther., September 1, 2008; 7(9): 3092 - 3102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Aleksunes, S. N. Campion, M. J. Goedken, and J. E. Manautou Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes Toxicol. Sci., August 1, 2008; 104(2): 261 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Md. T. Hoque and S. P.C. Cole Down-regulation of Na+/H+ Exchanger Regulatory Factor 1 Increases Expression and Function of Multidrug Resistance Protein 4 Cancer Res., June 15, 2008; 68(12): 4802 - 4809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Cropp, T. Komori, J. E. Shima, T. J. Urban, S. W. Yee, S. S. More, and K. M. Giacomini Organic Anion Transporter 2 (SLC22A7) Is a Facilitative Transporter of cGMP Mol. Pharmacol., April 1, 2008; 73(4): 1151 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. P. Lin, Y.-L. Zhu, D. R. Johnson, K. P. Rice, T. Nottoli, B. C. Hains, J. McGrath, S. G. Waxman, and A. C. Sartorelli Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response Mol. Pharmacol., January 1, 2008; 73(1): 243 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Reichel, R. Masereeuw, J. J. M. W. van den Heuvel, D. S. Miller, and G. Fricker Transport of a fluorescent cAMP analog in teleost proximal tubules Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2382 - R2389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Lickteig, C. D. Fisher, L. M. Augustine, L. M. Aleksunes, D. G. Besselsen, A. L. Slitt, J. E. Manautou, and N. J. Cherrington Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease Drug Metab. Dispos., October 1, 2007; 35(10): 1970 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Wolff, B. C. Burckhardt, G. Burckhardt, M. Oellerich, and V. W. Armstrong Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2497 - 2503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takenaka, J. A. Morgan, G. L. Scheffer, M. Adachi, C. F. Stewart, D. Sun, M. Leggas, K. F.K. Ejendal, C. A. Hrycyna, and J. D. Schuetz Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution Cancer Res., July 15, 2007; 67(14): 6965 - 6972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Willoughby and D. M. F. Cooper Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains Physiol Rev, July 1, 2007; 87(3): 965 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Belinsky, P. Guo, K. Lee, F. Zhou, E. Kotova, A. Grinberg, H. Westphal, I. Shchaveleva, A. Klein-Szanto, J. M. Gallo, et al. Multidrug Resistance Protein 4 Protects Bone Marrow, Thymus, Spleen, and Intestine from Nucleotide Analogue-Induced Damage Cancer Res., January 1, 2007; 67(1): 262 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Zamek-Gliszczynski, K.-i. Nezasa, X. Tian, A. S. Bridges, K. Lee, M. G. Belinsky, G. D. Kruh, and K. L. R. Brouwer Evaluation of the Role of Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 in Hepatic Basolateral Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Abcc3-/- and Abcc4-/- Mice J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 1485 - 1491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sun, L. Liu, and K. S. Pang Increased Estrogen Sulfation of Estradiol 17beta-D-Glucuronide in Metastatic Tumor Rat Livers J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 818 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jungsuwadee, M. P. Cole, R. Sultana, G. Joshi, J. Tangpong, D. A. Butterfield, D. K. St. Clair, and M. Vore Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 mice. Mol. Cancer Ther., November 1, 2006; 5(11): 2851 - 2860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Choudhuri and C. D. Klaassen Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters International Journal of Toxicology, July 1, 2006; 25(4): 231 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Deeley, C. Westlake, and S. P. C. Cole Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins. Physiol Rev, July 1, 2006; 86(3): 849 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Andric, T. S. Kostic, and S. S. Stojilkovic Contribution of Multidrug Resistance Protein MRP5 in Control of Cyclic Guanosine 5'-Monophosphate Intracellular Signaling in Anterior Pituitary Cells Endocrinology, July 1, 2006; 147(7): 3435 - 3445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dallas, D. S. Miller, and R. Bendayan Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol. Rev., June 1, 2006; 58(2): 140 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Aleksunes, G. L. Scheffer, A. B. Jakowski, I. M. Pruimboom-Brees, and J. E. Manautou Coordinated Expression of Multidrug Resistance-Associated Proteins (Mrps) in Mouse Liver during Toxicant-Induced Injury Toxicol. Sci., February 1, 2006; 89(2): 370 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bronger, J. Konig, K. Kopplow, H.-H. Steiner, R. Ahmadi, C. Herold-Mende, D. Keppler, and A. T. Nies ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier Cancer Res., December 15, 2005; 65(24): 11419 - 11428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Maher, A. L. Slitt, N. J. Cherrington, X. Cheng, and C. D. Klaassen TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE Drug Metab. Dispos., July 1, 2005; 33(7): 947 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Belinsky, P. A. Dawson, I. Shchaveleva, L. J. Bain, R. Wang, V. Ling, Z.-S. Chen, A. Grinberg, H. Westphal, A. Klein-Szanto, et al. Analysis of the In Vivo Functions of Mrp3 Mol. Pharmacol., July 1, 2005; 68(1): 160 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wielinga, J. H. Hooijberg, S. Gunnarsdottir, I. Kathmann, G. Reid, N. Zelcer, K. van der Born, M. de Haas, I. van der Heijden, G. Kaspers, et al. The Human Multidrug Resistance Protein MRP5 Transports Folates and Can Mediate Cellular Resistance against Antifolates Cancer Res., May 15, 2005; 65(10): 4425 - 4430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pratt, R. L. Shepard, R. A. Kandasamy, P. A. Johnston, W. Perry III, and A. H. Dantzig The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites Mol. Cancer Ther., May 1, 2005; 4(5): 855 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-S. Chen, Y. Guo, M. G. Belinsky, E. Kotova, and G. D. Kruh Transport of Bile Acids, Sulfated Steroids, Estradiol 17-{beta}-D-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11) Mol. Pharmacol., February 1, 2005; 67(2): 545 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. M. H. Van Aubel, P. H. E. Smeets, J. J. M. W. van den Heuvel, and F. G. M. Russel Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites Am J Physiol Renal Physiol, February 1, 2005; 288(2): F327 - F333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-L. Xu, H. M. Wolde, V. Gavrilyuk, V. L. Baughman, and D. A. Pelligrino cAMP modulates cGMP-mediated cerebral arteriolar relaxation in vivo Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2501 - H2509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Jedlitschky, K. Tirschmann, L. E. Lubenow, H. K. Nieuwenhuis, J. W. N. Akkerman, A. Greinacher, and H. K. Kroemer The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage Blood, December 1, 2004; 104(12): 3603 - 3610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. E. Sauna, K. Nandigama, and S. V. Ambudkar Multidrug Resistance Protein 4 (ABCC4)-mediated ATP Hydrolysis: EFFECT OF TRANSPORT SUBSTRATES AND CHARACTERIZATION OF THE POST-HYDROLYSIS TRANSITION STATE J. Biol. Chem., November 19, 2004; 279(47): 48855 - 48864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H.E. Smeets, R. A.M.H. van Aubel, A. C. Wouterse, J. J.M.W. van den Heuvel, and F. G.M. Russel Contribution of Multidrug Resistance Protein 2 (MRP2/ABCC2) to the Renal Excretion of p-aminohippurate (PAH) and Identification of MRP4 (ABCC4) as a Novel PAH Transporter J. Am. Soc. Nephrol., November 1, 2004; 15(11): 2828 - 2835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Morioka, K. Kumagai, K. Morita, S. Kitayama, and T. Dohi Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium (MPP+)-Induced Cell Death by Promoting the Intracellular Accumulation of MPP+ in PC12 Cells J. Pharmacol. Exp. Ther., August 1, 2004; 310(2): 800 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hopper-Borge, Z.-S. Chen, I. Shchaveleva, M. G. Belinsky, and G. D. Kruh Analysis of the Drug Resistance Profile of Multidrug Resistance Protein 7 (ABCC10): Resistance to Docetaxel Cancer Res., July 15, 2004; 64(14): 4927 - 4930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Wright and W. H. Dantzler Molecular and Cellular Physiology of Renal Organic Cation and Anion Transport Physiol Rev, July 1, 2004; 84(3): 987 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dallas, L. Schlichter, and R. Bendayan Multidrug Resistance Protein (MRP) 4- and MRP 5-Mediated Efflux of 9-(2-Phosphonylmethoxyethyl)adenine by Microglia J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 1221 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dazert, K. Meissner, S. Vogelgesang, B. Heydrich, L. Eckel, M. Bohm, R. Warzok, R. Kerb, U. Brinkmann, E. Schaeffeler, et al. Expression and Localization of the Multidrug Resistance Protein 5 (MRP5/ABCC5), a Cellular Export Pump for Cyclic Nucleotides, in Human Heart Am. J. Pathol., October 1, 2003; 163(4): 1567 - 1577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Guo, E. Kotova, Z.-S. Chen, K. Lee, E. Hopper-Borge, M. G. Belinsky, and G. D. Kruh MRP8, ATP-binding Cassette C11 (ABCC11), Is a Cyclic Nucleotide Efflux Pump and a Resistance Factor for Fluoropyrimidines 2',3'-Dideoxycytidine and 9'-(2'-Phosphonylmethoxyethyl)adenine J. Biol. Chem., August 8, 2003; 278(32): 29509 - 29514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Reid, P. Wielinga, N. Zelcer, I. van der Heijden, A. Kuil, M. de Haas, J. Wijnholds, and P. Borst The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs PNAS, August 5, 2003; 100(16): 9244 - 9249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. F. Krynetskaia, T. L. Brenner, E. Y. Krynetski, W. Du, J. C. Panetta, P. Ching-Hon, and W. E. Evans Msh2 Deficiency Attenuates But Does Not Abolish Thiopurine Hematopoietic Toxicity in Msh2-/- Mice Mol. Pharmacol., August 1, 2003; 64(2): 456 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-S. Chen, R. W. Robey, M. G. Belinsky, I. Shchaveleva, X.-Q. Ren, Y. Sugimoto, D. D. Ross, S. E. Bates, and G. D. Kruh Transport of Methotrexate, Methotrexate Polyglutamates, and 17{beta}-Estradiol 17-({beta}-D-glucuronide) by ABCG2: Effects of Acquired Mutations at R482 on Methotrexate Transport Cancer Res., July 15, 2003; 63(14): 4048 - 4054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J E Ros, T A D Roskams, M Geuken, R Havinga, P L Splinter, B E Petersen, N F LaRusso, D M van der Kolk, F Kuipers, K N Faber, et al. ATP binding cassette transporter gene expression in rat liver progenitor cells Gut, July 1, 2003; 52(7): 1060 - 1067. [Abstract] [Full Text]
|
|
|
|
|
|
P. R. Wielinga, I. van der Heijden, G. Reid, J. H. Beijnen, J. Wijnholds, and P. Borst Characterization of the MRP4- and MRP5-mediated Transport of Cyclic Nucleotides from Intact Cells J. Biol. Chem., May 9, 2003; 278(20): 17664 - 17671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Reid, P. Wielinga, N. Zelcer, M. de Haas, L. van Deemter, J. Wijnholds, J. Balzarini, and P. Borst Characterization of the Transport of Nucleoside Analog Drugs by the Human Multidrug Resistance Proteins MRP4 and MRP5 Mol. Pharmacol., May 1, 2003; 63(5): 1094 - 1103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-S. Chen, E. Hopper-Borge, M. G. Belinsky, I. Shchaveleva, E. Kotova, and G. D. Kruh Characterization of the Transport Properties of Human Multidrug Resistance Protein 7 (MRP7, ABCC10) Mol. Pharmacol., February 1, 2003; 63(2): 351 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Lamba, M. Adachi, D. Sun, J. Tammur, E. G. Schuetz, R. Allikmets, and J. D. Schuetz Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons Hum. Mol. Genet., January 15, 2003; 12(2): 99 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Wielinga, G. Reid, E. E. Challa, I. van der Heijden, L. van Deemter, M. de Haas, C. Mol, A. J. Kuil, E. Groeneveld, J. D. Schuetz, et al. Thiopurine Metabolism and Identification of the Thiopurine Metabolites Transported by MRP4 and MRP5 Overexpressed in Human Embryonic Kidney Cells Mol. Pharmacol., December 1, 2002; 62(6): 1321 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Belinsky, Z.-S. Chen, I. Shchaveleva, H. Zeng, and G. D. Kruh Characterization of the Drug Resistance and Transport Properties of Multidrug Resistance Protein 6 (MRP6, ABCC6) Cancer Res., November 1, 2002; 62(21): 6172 - 6177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Adachi, J. Sampath, L.-b. Lan, D. Sun, P. Hargrove, R. Flatley, A. Tatum, M. Z. Edwards, M. Wezeman, L. Matherly, et al. Expression of MRP4 Confers Resistance to Ganciclovir and Compromises Bystander Cell Killing J. Biol. Chem., October 4, 2002; 277(41): 38998 - 39004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. P. Lin, D. R. Johnson, R. A. Finch, M. G. Belinsky, G. D. Kruh, and A. C. Sartorelli Comparative Study of the Importance of Multidrug Resistance-associated Protein 1 and P-Glycoprotein to Drug Sensitivity in Immortalized Mouse Embryonic Fibroblasts Mol. Cancer Ther., October 1, 2002; 1(12): 1105 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-S. Chen, K. Lee, S. Walther, R. B. Raftogianis, M. Kuwano, H. Zeng, and G. D. Kruh Analysis of Methotrexate and Folate Transport by Multidrug Resistance Protein 4 (ABCC4): MRP4 Is a Component of the Methotrexate Efflux System Cancer Res., June 1, 2002; 62(11): 3144 - 3150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. M. H. van Aubel, P. H. E. Smeets, J. G. P. Peters, R. J. M. Bindels, and F. G. M. Russel The MRP4/ABCC4 Gene Encodes a Novel Apical Organic Anion Transporter in Human Kidney Proximal Tubules: Putative Efflux Pump for Urinary cAMP and cGMP J. Am. Soc. Nephrol., March 1, 2002; 13(3): 595 - 603. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |