JBC PeproTech; Our Business is Cytokines!

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M102051200 on August 2, 2001

J. Biol. Chem., Vol. 276, Issue 38, 35644-35651, September 21, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/38/35644    most recent
M102051200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murakumo, Y.
Right arrow Articles by Takahashi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murakumo, Y.
Right arrow Articles by Takahashi, M.

Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7*

Yoshiki MurakumoDagger §, Yukiko OguraDagger , Hideshi Ishii, Shin-ichiro Numata, Masatoshi IchiharaDagger , Carlo M. Croce, Richard Fishel, and Masahide TakahashiDagger

From the Dagger  Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan and the  Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Most mutations after DNA damage in yeast Saccharomyces cerevisiae are induced by error-prone translesion DNA synthesis employing scRev1 and DNA polymerase zeta  that consists of scRev3 and scRev7 proteins. Recently, the human REV1 (hREV1) and REV3 (hREV3) genes were identified, and their products were revealed to be involved in UV-induced mutagenesis, as observed for their yeast counterparts. Human REV7 (hREV7) was also cloned, and its product was found to interact with hREV3, but the biological function of hREV7 remained unknown. We report here the analyses of precise interactions in the human REV proteins. The interaction between hREV1 and hREV7 was identified by the yeast two-hybrid library screening using a bait of hREV7, which was confirmed by in vitro and in vivo binding assays. The homodimerization of hREV7 was also detected in the two-hybrid analysis. In addition, the precise domains for interaction between hREV7 and hREV1 or hREV3 and for hREV7 homodimerization were determined. Although hREV7 interacts with both hREV1 and hREV3, a stable complex formation of the three proteins was undetectable in vitro. These findings suggest the possibility that hREV7 might play an important role in regulating the enzymatic activities of hREV1 and hREV3 for mutagenesis in response to DNA damage.

* This work was supported by a grant-in-aid for COE (Center of Excellence) research from the Ministry of Education, Science, Sports and Culture of Japan.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF357886.

§ To whom correspondence should be addressed. Tel.: 81-52-744-2093; Fax: 81-52-744-2098; E-mail: murakumo@med.nagoya-u.ac.jp.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.


This article has been cited by other articles:


Home page
 Plant Physiol.Home page
S. Takahashi, A. N. Sakamoto, A. Tanaka, and K. Shimizu
AtREV1, a Y-Family DNA Polymerase in Arabidopsis, Has Deoxynucleotidyl Transferase Activity in Vitro
Plant Physiology, November 1, 2007; 145(3): 1052 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Wood, P. Garg, and P. M. J. Burgers
A Ubiquitin-binding Motif in the Translesion DNA Polymerase Rev1 Mediates Its Essential Functional Interaction with Ubiquitinated Proliferating Cell Nuclear Antigen in Response to DNA Damage
J. Biol. Chem., July 13, 2007; 282(28): 20256 - 20263.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Zhang, S.-H. Yang, and A. D. Sharrocks
Rev7/MAD2B Links c-Jun N-Terminal Protein Kinase Pathway Signaling to Activation of the Transcription Factor Elk-1
Mol. Cell. Biol., April 15, 2007; 27(8): 2861 - 2869.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Guo, T.-S. Tang, M. Bienko, J. L. Parker, A. B. Bielen, E. Sonoda, S. Takeda, H. D. Ulrich, I. Dikic, and E. C. Friedberg
Ubiquitin-Binding Motifs in REV1 Protein Are Required for Its Role in the Tolerance of DNA Damage
Mol. Cell. Biol., December 1, 2006; 26(23): 8892 - 8900.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. D'Souza and G. C. Walker
Novel Role for the C Terminus of Saccharomyces cerevisiae Rev1 in Mediating Protein-Protein Interactions
Mol. Cell. Biol., November 1, 2006; 26(21): 8173 - 8182.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Masuda and K. Kamiya
Role of Single-stranded DNA in Targeting REV1 to Primer Termini
J. Biol. Chem., August 25, 2006; 281(34): 24314 - 24321.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. S. Waters and G. C. Walker
The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G2/M phase rather than S phase
PNAS, June 13, 2006; 103(24): 8971 - 8976.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Shen, S. Jun, L. E. O'Neal, E. Sonoda, M. Bemark, J. E. Sale, and L. Li
REV3 and REV1 Play Major Roles in Recombination-independent Repair of DNA Interstrand Cross-links Mediated by Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA)
J. Biol. Chem., May 19, 2006; 281(20): 13869 - 13872.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
X. Lin, T. Okuda, J. Trang, and S. B. Howell
Human REV1 Modulates the Cytotoxicity and Mutagenicity of Cisplatin in Human Ovarian Carcinoma Cells
Mol. Pharmacol., May 1, 2006; 69(5): 1748 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Takeuchi, T. Ruike, R.-i. Nakamura, K. Shimanouchi, Y. Kanai, Y. Abe, A. Ihara, and K. Sakaguchi
Drosophila DNA Polymerase {zeta} Interacts with Recombination Repair Protein 1, the Drosophila Homologue of Human Abasic Endonuclease 1
J. Biol. Chem., April 28, 2006; 281(17): 11577 - 11585.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. W. Cheung, A. C.S. Chun, Q. Wang, W. Deng, L. Hu, X.-Y. Guan, J. M. Nicholls, M.-T. Ling, Y. Chuan Wong, S. Wah Tsao, et al.
Inactivation of Human MAD2B in Nasopharyngeal Carcinoma Cells Leads to Chemosensitization to DNA-Damaging Agents.
Cancer Res., April 15, 2006; 66(8): 4357 - 4367.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
H. Zhang, A. Chatterjee, and K. K. Singh
Saccharomyces cerevisiae Polymerase {zeta} Functions in Mitochondria
Genetics, April 1, 2006; 172(4): 2683 - 2688.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
Y. Murakumo, S. Mizutani, M. Yamaguchi, M. Ichihara, and M. Takahashi
Analyses of ultraviolet-induced focus formation of hREV1 protein
Genes Cells, March 1, 2006; 11(3): 193 - 205.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Takenaka, T. Ogi, T. Okada, E. Sonoda, C. Guo, E. C. Friedberg, and S. Takeda
Involvement of Vertebrate Pol{kappa} in Translesion DNA Synthesis across DNA Monoalkylation Damage
J. Biol. Chem., January 27, 2006; 281(4): 2000 - 2004.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Acharya, L. Haracska, R. E. Johnson, I. Unk, S. Prakash, and L. Prakash
Complex Formation of Yeast Rev1 and Rev7 Proteins: a Novel Role for the Polymerase-Associated Domain
Mol. Cell. Biol., November 1, 2005; 25(21): 9734 - 9740.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Okada, E. Sonoda, M. Yoshimura, Y. Kawano, H. Saya, M. Kohzaki, and S. Takeda
Multiple Roles of Vertebrate REV Genes in DNA Repair and Recombination
Mol. Cell. Biol., July 15, 2005; 25(14): 6103 - 6111.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A.-L. Ross, L. J. Simpson, and J. E. Sale
Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1
Nucleic Acids Res., March 1, 2005; 33(4): 1280 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. Mukhopadhyay, D. R. Clark, N. B. Watson, W. Zacharias, and W. G. McGregor
REV1 accumulates in DNA damage-induced nuclear foci in human cells and is implicated in mutagenesis by benzo[a]pyrenediolepoxide
Nucleic Acids Res., November 2, 2004; 32(19): 5820 - 5826.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
E. Ohashi, Y. Murakumo, N. Kanjo, J.-i. Akagi, C. Masutani, F. Hanaoka, and H. Ohmori
Interaction of hREV1 with three human Y-family DNA polymerases
Genes Cells, June 1, 2004; 9(6): 523 - 531.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. Guo, Z. Xie, H. Shen, B. Zhao, and Z. Wang
Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase {zeta} is stimulated by yeast Rev1 protein
Nucleic Acids Res., February 11, 2004; 32(3): 1122 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. R. Clark, W. Zacharias, L. Panaitescu, and W. G. McGregor
Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene
Nucleic Acids Res., September 1, 2003; 31(17): 4981 - 4988.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
M. Diaz, N. B. Watson, G. Turkington, L. K. Verkoczy, N. R. Klinman, and W. G. McGregor
Decreased Frequency and Highly Aberrant Spectrum of Ultraviolet-Induced Mutations in the hprt Gene of Mouse Fibroblasts Expressing Antisense RNA to DNA Polymerase {zeta}
Mol. Cancer Res., September 1, 2003; 1(11): 836 - 847.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Masuda, M. Ohmae, K. Masuda, and K. Kamiya
Structure and Enzymatic Properties of a Stable Complex of the Human REV1 and REV7 Proteins
J. Biol. Chem., March 28, 2003; 278(14): 12356 - 12360.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. Zhang, X. Wu, O. Rechkoblit, N. E. Geacintov, J.-S. Taylor, and Z. Wang
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion
Nucleic Acids Res., April 1, 2002; 30(7): 1630 - 1638.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.