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J. Biol. Chem., Vol. 276, Issue 39, 36824-36830, September 28, 2001
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From the Departments of NRL, a bZIP transcription factor of the
Maf subfamily, interacts with the homeodomain protein CRX and
synergistically regulates rhodopsin expression. Here we report that six
isoforms of NRL (29-35 kDa) are generated by phosphorylation and
expressed specifically in the mammalian retina. The anti-NRL antibody
also cross-reacts with a cytosolic 45-kDa protein, which is detected in
neuronal tissues but is not encoded by the NRL gene.
In both human retinal cell cultures and sections of fetal and adult
human retina, NRL is present in the nuclei of developing and mature
rods but not cones. We propose that NRL regulates rod
photoreceptor-specific gene expression and is involved in rod differentiation.
Multiple Phosphorylated Isoforms of NRL Are Expressed in Rod
Photoreceptors*
,,,
**,§§
Ophthalmology and Visual
Sciences and Human Genetics, University of
Michigan, Ann Arbor, Michigan 48105, the § Laboratoire de
Physiopathologie Cellulaire et Moléculaire de la Rétine,
INSERM Universite Louis Pasteur E9918, Centre Hospitalier Universitaire
Régional, 67091 Strasbourg, France, the ¶ Scheie Eye
Institute, University of Pennsylvania, Philadelphia, Pennsylvania
19104, and the Department of Biological Structure, University of
Washington, Seattle, Washington 98195-5320
*
This research was supported in parts by Grants EY11115,
EY04536, EY01730, and EY07003 from the National Institutes of Health and grants from Fight for Sight, the Foundation Fighting Blindness, the
Paul and Evanina Bell Mackall Foundation Trust, Research to Prevent
Blindness, and the British Retinitis Pigmentosa Society.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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