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J. Biol. Chem., Vol. 276, Issue 43, 40050-40054, October 26, 2001
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From the The vacuolar-type H+-ATPase
(V-ATPase) translocates protons across membranes. Here, we have
identified a mouse cDNA coding for a fourth isoform
(a4) of the membrane sector subunit a of V-ATPase. This isoform was specifically expressed in kidney, but not in
the heart, brain, spleen, lung, liver, muscle, or testis. Immunoprecipitation experiments, together with sequence similarities for other isoforms (a1, a2, and
a3), indicate that the a4 isoform is a
component of V-ATPase. Moreover, histochemical studies show that
a4 is localized in the apical and basolateral plasma
membranes of cortical The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AB050903.
a4, a Unique Kidney-specific Isoform of Mouse
Vacuolar H+-ATPase Subunit a*
,,,,,,, and
Division of Biological Sciences, Institute
of Scientific and Industrial Research, Osaka University, Core
Research for Evolutional Science and Technology (CREST) of the Japan
Science and Technology Corporation, Osaka 567-0047, Japan, the
§ Department of Physiology, Kansai Medical University,
Moriguchi, Osaka 570-8506, Japan, and the ¶ Department of Clinical
Chemistry and Laboratory Medicine, Kyushu University, Fukuoka 812-8582, Japan
- and 
-intercalated cells, respectively.
These results suggest that the V-ATPase, with the a4
isoform, is important for renal acid/base homeostasis.
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.:
81-6-6879-8480; Fax: 81-6-6875-5724; E-mail:
m-futai@sanken.osaka-u.ac.jp.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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