|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 276, Issue 43, 40146-40155, October 26, 2001
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Departments of We examined the phosphorylation and acetylation
of histone H3 in ovarian granulosa cells stimulated to differentiate by
follicle-stimulating hormone (FSH). We found that protein kinase A
(PKA) mediates H3 phosphorylation on serine 10, based on inhibition
exclusively by PKA inhibitors. FSH-stimulated H3 phosphorylation in
granulosa cells is not downstream of mitogen-activated protein
kinase/extracellular signal-regulated kinase, ribosomal S6
kinase-2, mitogen- and stress-activated protein kinase-1, p38 MAPK,
phosphatidylinositol-3 kinase, or protein kinase C. Transcriptional
activation-associated H3 phosphorylation on serine 10 and acetylation
of lysine 14 leads to activation of serum glucocorticoid kinase,
inhibin
Follicle-stimulating Hormone Stimulates Protein Kinase A-mediated
Histone H3 Phosphorylation and Acetylation Leading to Select Gene
Activation in Ovarian Granulosa Cells*
§,
,§**,,,,,¶¶
Cell and Molecular
Biology and ¶ Medicine, Division of Endocrinology,
Metabolism, and Molecular Medicine, Northwestern University Medical
School, Chicago, Illinois 60611, Veterans Affairs Medical Center and Oregon
Health Sciences University, Portland, Oregon 97201, and
§§ Biochemistry and Molecular Genetics,
University of Virginia, Charlottesville, Virginia 22908
, and c-fos genes. We propose that
phosphorylation of histone H3 on serine 10 by PKA in coordination with
acetylation of H3 on lysine 14 results in reorganization of the
promoters of select FSH responsive genes into a more accessible
configuration for activation. The unique role of PKA as the
physiological histone H3 kinase is consistent with the central
role of PKA in initiating granulosa cell differentiation.
*
This work was funded by Grants P01 HD21921 (to
M. H. D. and J. L. J.), GM40922 (to C. D. A), and HD36408 (to
D. W. C.) from the National Institutes of Health and by U. S. Army
USAMRMC Grant DAMD 17-00-1-0386 (to L. M. S.). Preliminary results
were presented at the 13th Ovarian Workshop, 2000, in Madison,
Wisconsin.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Youngkyu Park is the recipient of an individual
National Research Service Award 5 F32 HD85602.
**
Present address: Wyeth Ayerst Women's Health Research Institute,
145 King of Prussia Rd., Radnor, PA 19087.
¶¶
To whom correspondence should be addressed:
Dept. of Cell and Molecular Biology, Northwestern University Medical
School, 303 East Chicago Ave., Chicago, IL 60611. Tel.: 312-503-8940;
Fax: 312-503-0566; E-mail: mhd@northwestern.edu.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  B. J. Deroo, K. F. Rodriguez, J. F. Couse, K. J. Hamilton, J. B. Collins, S. F. Grissom, and K. S. Korach Estrogen Receptor {beta} Is Required for Optimal cAMP Production in Mouse Granulosa Cells Mol. Endocrinol., July 1, 2009; 23(7): 955 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Price, R. Kanyo, N. Steinberg, C. L. Chik, and A. K. Ho Nocturnal Activation of Aurora C in Rat Pineal Gland: Its Role in the Norepinephrine-Induced Phosphorylation of Histone H3 and Gene Expression Endocrinology, May 1, 2009; 150(5): 2334 - 2341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Inagaki, F. Otsuka, T. Miyoshi, M. Yamashita, M. Takahashi, J. Goto, J. Suzuki, and H. Makino p38-Mitogen-Activated Protein Kinase Stimulated Steroidogenesis in Granulosa Cell-Oocyte Cocultures: Role of Bone Morphogenetic Proteins 2 and 4 Endocrinology, April 1, 2009; 150(4): 1921 - 1930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. F. Ackermann, K. M. Boini, H. Volkl, M. Bhandaru, P. M. Bareiss, L. Just, V. Vallon, K. Amann, D. Kuhl, Y. Feng, et al. SGK1-sensitive renal tubular glucose reabsorption in diabetes Am J Physiol Renal Physiol, April 1, 2009; 296(4): F859 - F866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Alam, J. Weck, E. Maizels, Y. Park, E. J. Lee, M. Ashcroft, and M. Hunzicker-Dunn Role of the Phosphatidylinositol-3-Kinase and Extracellular Regulated Kinase Pathways in the Induction of Hypoxia-Inducible Factor (HIF)-1 Activity and the HIF-1 Target Vascular Endothelial Growth Factor in Ovarian Granulosa Cells in Response to Follicle-Stimulating Hormone Endocrinology, February 1, 2009; 150(2): 915 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Flynn, E. T. Maizels, A. B. Karlsson, T. McAvoy, J.-H. Ahn, A. C. Nairn, and M. Hunzicker-Dunn Luteinizing Hormone Receptor Activation in Ovarian Granulosa Cells Promotes Protein Kinase A-Dependent Dephosphorylation of Microtubule-Associated Protein 2D Mol. Endocrinol., July 1, 2008; 22(7): 1695 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Islam and C. R. Mendelson Glucocorticoid/Glucocorticoid Receptor Inhibition of Surfactant Protein-A (SP-A) Gene Expression in Lung Type II Cells Is Mediated by Repressive Changes in Histone Modification at the SP-A Promoter Mol. Endocrinol., March 1, 2008; 22(3): 585 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Wayne, H.-Y. Fan, X. Cheng, and J. S. Richards Follicle-Stimulating Hormone Induces Multiple Signaling Cascades: Evidence that Activation of Rous Sarcoma Oncogene, RAS, and the Epidermal Growth Factor Receptor Are Critical for Granulosa Cell Differentiation Mol. Endocrinol., August 1, 2007; 21(8): 1940 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kwintkiewicz, Z. Cai, and C. Stocco Follicle-Stimulating Hormone-Induced Activation of Gata4 Contributes in the Up-Regulation of Cyp19 Expression in Rat Granulosa Cells Mol. Endocrinol., April 1, 2007; 21(4): 933 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Chik, T. G. Arnason, W. G. Dukewich, D. M. Price, A. Ranger, and A. K. Ho Histone H3 Phosphorylation in the Rat Pineal Gland: Adrenergic Regulation and Diurnal Variation Endocrinology, April 1, 2007; 148(4): 1465 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lang, C. Bohmer, M. Palmada, G. Seebohm, N. Strutz-Seebohm, and V. Vallon (Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms. Physiol Rev, October 1, 2006; 86(4): 1151 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lazzaro, D. Pepin, N. Pescador, B. D. Murphy, B. C. Vanderhyden, and D. J. Picketts The Imitation Switch Protein SNF2L Regulates Steroidogenic Acute Regulatory Protein Expression during Terminal Differentiation of Ovarian Granulosa Cells Mol. Endocrinol., October 1, 2006; 20(10): 2406 - 2417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, S. Batra, S. Korrapati, V. Mishra, and K. D. Mehta Selective Repression of Low-Density Lipoprotein Receptor Expression by SP600125: Coupling of Histone H3-Ser10 Phosphorylation and Sp1 Occupancy Mol. Cell. Biol., February 15, 2006; 26(4): 1307 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. T. Ruiz-Cortes, S. Kimmins, L. Monaco, K. H. Burns, P. Sassone-Corsi, and B. D. Murphy Estrogen Mediates Phosphorylation of Histone H3 in Ovarian Follicle and Mammary Epithelial Tumor Cells via the Mitotic Kinase, Aurora B Mol. Endocrinol., December 1, 2005; 19(12): 2991 - 3000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Schmeck, W. Beermann, V. van Laak, J. Zahlten, B. Opitz, M. Witzenrath, A. C. Hocke, T. Chakraborty, M. Kracht, S. Rosseau, et al. Intracellular Bacteria Differentially Regulated Endothelial Cytokine Release by MAPK-Dependent Histone Modification J. Immunol., September 1, 2005; 175(5): 2843 - 2850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Akbarian, M. G. Ruehl, E. Bliven, L. A. Luiz, A. C. Peranelli, S. P. Baker, R. C. Roberts, W. E. Bunney Jr, R. C. Conley, E. G. Jones, et al. Chromatin Alterations Associated With Down-regulated Metabolic Gene Expression in the Prefrontal Cortex of Subjects With Schizophrenia Arch Gen Psychiatry, August 1, 2005; 62(8): 829 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Ongeri, M. F. Verderame, and J. M. Hammond Follicle-Stimulating Hormone Induction of Ovarian Insulin-Like Growth Factor-Binding Protein-3 Transcription Requires a TATA Box-Binding Protein and the Protein Kinase A and Phosphatidylinositol-3 Kinase Pathways Mol. Endocrinol., July 1, 2005; 19(7): 1837 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Bode and Z. Dong Inducible Covalent Posttranslational Modification of Histone H3 Sci. Signal., April 26, 2005; 2005(281): re4 - re4. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rusovici, Y. Y. Hui, and H. A. LaVoie Epidermal Growth Factor-Mediated Inhibition of Follicle-Stimulating Hormone-Stimulated StAR Gene Expression in Porcine Granulosa Cells Is Associated with Reduced Histone H3 Acetylation Biol Reprod, April 1, 2005; 72(4): 862 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Huang, M. Rastegar, C. Bodner, S.-L. Goh, I. Rambaldi, and M. Featherstone MEIS C Termini Harbor Transcriptional Activation Domains That Respond to Cell Signaling J. Biol. Chem., March 18, 2005; 280(11): 10119 - 10127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Park, E. T. Maizels, Z. J. Feiger, H. Alam, C. A. Peters, T. K. Woodruff, T. G. Unterman, E. J. Lee, J. L. Jameson, and M. Hunzicker-Dunn Induction of Cyclin D2 in Rat Granulosa Cells Requires FSH-dependent Relief from FOXO1 Repression Coupled with Positive Signals from Smad J. Biol. Chem., March 11, 2005; 280(10): 9135 - 9148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Nelson-Degrave, J. K. Wickenheisser, K. L. Hendricks, T. Asano, M. Fujishiro, R. S. Legro, S. R. Kimball, J. F. Strauss III, and J. M. McAllister Alterations in Mitogen-Activated Protein Kinase Kinase and Extracellular Regulated Kinase Signaling in Theca Cells Contribute to Excessive Androgen Production in Polycystic Ovary Syndrome Mol. Endocrinol., February 1, 2005; 19(2): 379 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Drobic, P. S. Espino, and J. R. Davie Mitogen- and Stress-Activated Protein Kinase 1 Activity and Histone H3 Phosphorylation in Oncogene-Transformed Mouse Fibroblasts Cancer Res., December 15, 2004; 64(24): 9076 - 9079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, V. Mishra, S. Batra, I. Dillon, and K. D. Mehta Phorbol ester promotes histone H3-Ser10 phosphorylation at the LDL receptor promoter in a protein kinase C-dependent manner J. Lipid Res., August 1, 2004; 45(8): 1519 - 1527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Alam, E. T. Maizels, Y. Park, S. Ghaey, Z. J. Feiger, N. S. Chandel, and M. Hunzicker-Dunn Follicle-stimulating Hormone Activation of Hypoxia-inducible Factor-1 by the Phosphatidylinositol 3-Kinase/AKT/Ras Homolog Enriched in Brain (Rheb)/Mammalian Target of Rapamycin (mTOR) Pathway Is Necessary for Induction of Select Protein Markers of Follicular Differentiation J. Biol. Chem., May 7, 2004; 279(19): 19431 - 19440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Brush, A. Guardiola, J. H. Connor, T.-P. Yao, and S. Shenolikar Deactylase Inhibitors Disrupt Cellular Complexes Containing Protein Phosphatases and Deacetylases J. Biol. Chem., February 27, 2004; 279(9): 7685 - 7691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Crosio, E. Heitz, C. D. Allis, E. Borrelli, and P. Sassone-Corsi Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons J. Cell Sci., December 15, 2003; 116(24): 4905 - 4914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Brenner, O. D. Slayden, W. H. Rodgers, H. O.D. Critchley, R. Carroll, X. J. Nie, and K. Mah Immunocytochemical assessment of mitotic activity with an antibody to phosphorylated histone H3 in the macaque and human endometrium Hum. Reprod., June 1, 2003; 18(6): 1185 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Schmierer, M. K. Schuster, A. Shkumatava, and K. Kuchler Activin A Signaling Induces Smad2, but Not Smad3, Requiring Protein Kinase A Activity in Granulosa Cells from the Avian Ovary J. Biol. Chem., May 30, 2003; 278(23): 21197 - 21203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kostrouchova, Z. Kostrouch, V. Saudek, J. Piatigorsky, and J. E. Rall BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development PNAS, April 29, 2003; 100(9): 5240 - 5245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Y. Gevry, E. Lalli, P. Sassone-Corsi, and B. D. Murphy Regulation of Niemann-Pick C1 Gene Expression by the 3'5'-Cyclic Adenosine Monophosphate Pathway in Steroidogenic Cells Mol. Endocrinol., April 1, 2003; 17(4): 704 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shen, H. Hovhannisyan, J. B. Lian, M. A. Montecino, G. S. Stein, J. L. Stein, and A. J. van Wijnen Transcriptional Induction of the Osteocalcin Gene During Osteoblast Differentiation Involves Acetylation of Histones H3 and H4 Mol. Endocrinol., April 1, 2003; 17(4): 743 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cottom, L. M. Salvador, E. T. Maizels, S. Reierstad, Y. Park, D. W. Carr, M. A. Davare, J. W. Hell, S. S. Palmer, P. Dent, et al. Follicle-stimulating Hormone Activates Extracellular Signal-regulated Kinase but Not Extracellular Signal-regulated Kinase Kinase through a 100-kDa Phosphotyrosine Phosphatase J. Biol. Chem., February 21, 2003; 278(9): 7167 - 7179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Salvador, E. Maizels, D. B. Hales, E. Miyamoto, H. Yamamoto, and M. Hunzicker-Dunn Acute Signaling by the LH Receptor Is Independent of Protein Kinase C Activation Endocrinology, August 1, 2002; 143(8): 2986 - 2994. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |