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J. Biol. Chem., Vol. 276, Issue 48, 44512-44520, November 30, 2001
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From the Departments of Liver regeneration in response to various forms
of liver injury is a complex process, which ultimately results in
restoration of the original liver mass and function. Because the
underlying mechanisms that initiate this response are still
incompletely defined, this study was aimed to identify novel factors.
Liver genes that were up-regulated 6 h after 70% hepatectomy
(PHx) in the rat were selected by cDNA subtractive hybridization.
Besides known genes associated with cell proliferation, several novel genes were isolated. The novel gene that was most up-regulated was
further studied. Its mRNA showed a liver-specific expression and
encoded a protein comprising 367 amino acids. The mouse and human
cDNA analogues were also isolated and appeared to be highly homologous. The human gene analogue was located at an apolipoprotein gene cluster on chromosome 11q23. The protein encoded by this gene had
appreciable homology with apolipoproteins A-I and A-IV. Maximal
expression of the gene in the rat liver and its gene product in rat
plasma was observed 6 h after PHx. The protein was present in
plasma fractions containing high density lipoprotein particles. Therefore, we have identified a novel apolipoprotein, designated apolipoprotein A-V, that is associated with an early phase of liver regeneration.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF202887, AF202888, AF327059, AF202889, and AF202890.
Apolipoprotein A-V
A NOVEL APOLIPOPROTEIN ASSOCIATED WITH AN EARLY PHASE OF LIVER
REGENERATION*
,,, and¶
Experimental Hepatology and
§ Experimental Internal Medicine, Academic Medical Center,
University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The
Netherlands
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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