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J. Biol. Chem., Vol. 276, Issue 49, 46533-46543, December 7, 2001
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From the The bone morphogenetic proteins (BMPs) regulate
early embryogenesis and morphogenesis of multiple organs, such as bone,
kidney, limbs, and muscle. Smad1 is one of the key signal transducers of BMPs and is responsible for transducing receptor activation signals
from the cytoplasm to the nucleus, where Smad1 serves as a
transcriptional regulator of various BMP-responsive genes. Based upon
the ability of Smad1 to bind multiple proteins involved in
proteasome-mediated degradation pathway, we investigated whether Smad1
could be a substrate for proteasome. We found that Smad1 is targeted to
proteasome for degradation in response to BMP type I receptor
activation. The targeting of Smad1 to proteasome involves not only the
receptor activation-induced Smad1 ubiquitination but also the targeting
functions of the ornithine decarboxylase antizyme and the proteasome
Proteasomal Degradation of Smad1 Induced by Bone
Morphogenetic Proteins*
§,
,, and
Virginia Mason Research Center, Seattle,
Washington 98101, the Department of
Immunology, University of Washington, Seattle, Washington 98195, and the ¶ Pediatric Surgical Research Laboratories,
Massachusetts General Hospital, Boston MA 02114
subunit HsN3. Our studies provide the first evidence for
BMP-induced proteasomal targeting and degradation of Smad1 and also
reveal new players and novel mechanisms involved in this important
aspect of Smad1 regulation and function.
*
This work was supported by Virginia Mason Research Center.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Current address: Dept. of Molecular Genetics and Biochemistry,
University of Pittsburgh Medical School, Pittsburgh, PA 15261.
**
To whom correspondence should be addressed: Virginia Mason Research
Center, 1201 Ninth Ave., Seattle, WA 98101. Tel.: 206-223-6842; Fax:
206-223-7543; E-mail: wangt@vmresearch.org.
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