JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M006807200 on October 27, 2000

J. Biol. Chem., Vol. 276, Issue 6, 4020-4027, February 9, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/6/4020    most recent
M006807200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Traven, A.
Right arrow Articles by Ingles, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Traven, A.
Right arrow Articles by Ingles, C. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Interorganellar Communication
ALTERED NUCLEAR GENE EXPRESSION PROFILES IN A YEAST MITOCHONDRIAL DNA MUTANT*

Ana TravenDagger §, Johnson M. S. Wong§, Deming Xu§, Mary SoptaDagger , and C. James Ingles§||**

From the Dagger  Department of Molecular Genetics, Institute Rudjer Boskovic, Bijenicka 54, 10000 Zagreb, Croatia and § Banting and Best Department of Medical Research and || Department of Molecular and Medical Genetics, University of Toronto, Ontario M5G 1L6, Canada

Communication between mitochondria and the nucleus is important for a variety of cellular processes such as carbohydrate and nitrogen metabolism, mating and sporulation, and cell growth and morphogenesis. It has long been known that the functional state of mitochondria can influence nuclear gene expression. For example, in yeast cells lacking the mitochondrial genome, the expression of several nuclear genes, such as CIT2 (citrate synthase), MRP13 (mitochondrial ribosomal protein), and DLD3 (D-lactate dehydrogenase) has been reported to be altered. Here we show by microarray analysis of the genome-wide transcription profile of Saccharomyces cerevisiae that yeast petite mutants lacking mitochondrial DNA induce genes coding for mitochondrial proteins, enzymes of the glycolytic pathway and of the citric acid cycle, cell wall components, membrane transporters, and genes normally induced by nutrient deprivation and a variety of stresses. Consistent with the observed induction of genes related to cell stress and those encoding membrane transporters, yeast petite cells showed increased resistance to severe heat shock and exhibited a pleiotropic drug resistance phenotype. The observed changes in nuclear gene expression in cells lacking mitochondrial DNA may have implications for the role of mitochondria in processes such as carcinogenesis and aging.

* This work was supported by a grant from the Medical Research Council (MRC) of Canada (to C. J. I.) and from the Croatian Ministry of Science and Technology (to M. S.). The Microarray Centre at the Ontario Cancer Institute is supported by funding from the MRC of Canada, the National Research Council of Canada, and the National Science and Engineering Research Council of Canada.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Recipient of a graduate scholarship from the Croatian Ministry of Science and Technology.

** To whom correspondence should be addressed: Banting and Best Dept. of Medical Research, University of Toronto, 112 College St., Toronto, Ontario M5G 1L6, Canada. Tel.: 416-978-7400; Fax: 416-978-8528; E-mail: cj.ingles@utoronto.ca.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
K. Gulshan, J. A. Schmidt, P. Shahi, and W. S. Moye-Rowley
Evidence for the Bifunctional Nature of Mitochondrial Phosphatidylserine Decarboxylase: Role in Pdr3-Dependent Retrograde Regulation of PDR5 Expression
Mol. Cell. Biol., October 1, 2008; 28(19): 5851 - 5864.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. Chen, X. Shi, R. Padmanabhan, Q. Wang, Z. Wu, S. C. Stevenson, M. Hild, D. Garza, and H. Li
Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster
Genome Res., January 1, 2008; 18(1): 123 - 136.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-S. Choi and G. M. Carman
Respiratory Deficiency Mediates the Regulation of CHO1-encoded Phosphatidylserine Synthase by mRNA Stability in Saccharomyces cerevisiae
J. Biol. Chem., October 26, 2007; 282(43): 31217 - 31227.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Shahi, K. Gulshan, and W. S. Moye-Rowley
Negative Transcriptional Regulation of Multidrug Resistance Gene Expression by an Hsp70 Protein
J. Biol. Chem., September 14, 2007; 282(37): 26822 - 26831.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
V. Stribinskis and K. S. Ramos
Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies
Nucleic Acids Res., February 28, 2007; 35(4): 1301 - 1311.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Panwar and W. S. Moye-Rowley
Long Chain Base Tolerance in Saccharomyces cerevisiae Is Induced by Retrograde Signals from the Mitochondria
J. Biol. Chem., March 10, 2006; 281(10): 6376 - 6384.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
P. Vandeputte, G. Larcher, T. Berges, G. Renier, D. Chabasse, and J.-P. Bouchara
Mechanisms of Azole Resistance in a Clinical Isolate of Candida tropicalis
Antimicrob. Agents Chemother., November 1, 2005; 49(11): 4608 - 4615.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
V. Stribinskis, H.-C. Heyman, S. R. Ellis, M. C. Steffen, and N. C. Martin
Rpm2p, a Component of Yeast Mitochondrial RNase P, Acts as a Transcriptional Activator in the Nucleus
Mol. Cell. Biol., August 1, 2005; 25(15): 6546 - 6558.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
S. Brun, F. Dalle, P. Saulnier, G. Renier, A. Bonnin, D. Chabasse, and J.-P. Bouchara
Biological consequences of petite mutations in Candida glabrata
J. Antimicrob. Chemother., August 1, 2005; 56(2): 307 - 314.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. V. Miceli and S. M. Jazwinski
Nuclear Gene Expression Changes Due to Mitochondrial Dysfunction in ARPE-19 Cells: Implications for Age-Related Macular Degeneration
Invest. Ophthalmol. Vis. Sci., May 1, 2005; 46(5): 1765 - 1773.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Zhang, A. Kolaczkowska, F. Devaux, S. L. Panwar, T. C. Hallstrom, C. Jacq, and W. S. Moye-Rowley
Transcriptional Regulation by Lge1p Requires a Function Independent of Its Role in Histone H2B Ubiquitination
J. Biol. Chem., January 28, 2005; 280(4): 2759 - 2770.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Valadi, K. Granath, L. Gustafsson, and L. Adler
Distinct Intracellular Localization of Gpd1p and Gpd2p, the Two Yeast Isoforms of NAD+-dependent Glycerol-3-phosphate Dehydrogenase, Explains Their Different Contributions to Redox-driven Glycerol Production
J. Biol. Chem., September 17, 2004; 279(38): 39677 - 39685.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
S. Brun, T. Berges, P. Poupard, C. Vauzelle-Moreau, G. Renier, D. Chabasse, and J.-P. Bouchara
Mechanisms of Azole Resistance in Petite Mutants of Candida glabrata
Antimicrob. Agents Chemother., May 1, 2004; 48(5): 1788 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Belli, M. M. Molina, J. Garcia-Martinez, J. E. Perez-Ortin, and E. Herrero
Saccharomyces cerevisiae Glutaredoxin 5-deficient Cells Subjected to Continuous Oxidizing Conditions Are Affected in the Expression of Specific Sets of Genes
J. Biol. Chem., March 26, 2004; 279(13): 12386 - 12395.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. Borghouts, A. Benguria, J. Wawryn, and S. M. Jazwinski
Rtg2 Protein Links Metabolism and Genome Stability in Yeast Longevity
Genetics, February 1, 2004; 166(2): 765 - 777.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Guaragnella and R. A. Butow
ATO3 Encoding a Putative Outward Ammonium Transporter Is an RTG-independent Retrograde Responsive Gene Regulated by GCN4 and the Ssy1-Ptr3-Ssy5 Amino Acid Sensor System
J. Biol. Chem., November 14, 2003; 278(46): 45882 - 45887.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
K. Sakaki, K. Tashiro, S. Kuhara, and K. Mihara
Response of Genes Associated with Mitochondrial Function to Mild Heat Stress in Yeast Saccharomyces cerevisiae
J. Biochem., September 1, 2003; 134(3): 373 - 384.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
S. Brun, C. Aubry, O. Lima, R. Filmon, T. Berges, D. Chabasse, and J.-P. Bouchara
Relationships between Respiration and Susceptibility to Azole Antifungals in Candida glabrata
Antimicrob. Agents Chemother., March 1, 2003; 47(3): 847 - 853.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. T. McCammon, C. B. Epstein, B. Przybyla-Zawislak, L. McAlister-Henn, and R. A. Butow
Global Transcription Analysis of Krebs Tricarboxylic Acid Cycle Mutants Reveals an Alternating Pattern of Gene Expression and Effects on Hypoxic and Oxidative Genes
Mol. Biol. Cell, March 1, 2003; 14(3): 958 - 972.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Zhou, M.-C. J. Kao, and W. H. Wong
From the Cover: Transitive functional annotation by shortest-path analysis of gene expression data
PNAS, October 1, 2002; 99(20): 12783 - 12788.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Hellauer, B. Akache, S. MacPherson, E. Sirard, and B. Turcotte
Zinc Cluster Protein Rdr1p Is a Transcriptional Repressor of the PDR5 Gene Encoding a Multidrug Transporter
J. Biol. Chem., May 10, 2002; 277(20): 17671 - 17676.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
E. R. Sumner and S. V. Avery
Phenotypic heterogeneity: differential stress resistance among individual cells of the yeast Saccharomyces cerevisiae
Microbiology, February 1, 2002; 148(2): 345 - 351.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Hellauer, E. Sirard, and B. Turcotte
Decreased Expression of Specific Genes in Yeast Cells Lacking Histone H1
J. Biol. Chem., April 20, 2001; 276(17): 13587 - 13592.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.