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Originally published In Press as doi:10.1074/jbc.M007939200 on November 21, 2000

J. Biol. Chem., Vol. 276, Issue 6, 4055-4062, February 9, 2001
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Regulation of the Glucose-6-phosphatase Gene by Glucose Occurs by Transcriptional and Post-transcriptional Mechanisms
DIFFERENTIAL EFFECT OF GLUCOSE AND XYLITOL*

Duna MassillonDagger

From the Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

To understand how glucose regulates the expression of the glucose-6-phosphatase gene, the effect of glucose was studied in primary cultures of rat hepatocytes. Glucose-6-phosphatase mRNA levels increased about 10-fold when hepatocytes were incubated with 20 mM glucose. The rate of transcription of the glucose-6-phosphatase gene increased about 3-fold in hepatocytes incubated with glucose. The half-life of glucose-6-phosphatase mRNA was estimated to be 90 min in the absence of glucose and 3 h in its presence. Inhibition of the oxidative and the nonoxidative branches of the pentose phosphate pathway blocked the stimulation of glucose-6-phosphatase expression by glucose but not by xylitol or carbohydrates that enter the glycolytic/gluconeogenic pathways at the level of the triose phosphates. These results indicate that (i) the glucose induction of the mRNA for the catalytic unit of glucose-6-phosphatase occurs by transcriptional and post-transcriptional mechanisms and that (ii) xylitol and glucose increase the expression of this gene through different signaling pathways.

* This work was supported by a Case Western Reserve University Faculty Fellowship from the Mount Sinai Health Care Foundation.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger Recipient of a Case Western Reserve University Faculty Fellowship from the Mount Sinai Health Care Foundation. To whom correspondence and reprint requests should be addressed: Dept. of Nutrition, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland OH 44106. Tel.: 216-368-2135; Fax: 216-368-6644; E-mail: dxm71@po.cwru.edu.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.


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