Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M008809200 on October 24, 2000

J. Biol. Chem., Vol. 276, Issue 7, 4634-4639, February 16, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/7/4634    most recent
M008809200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dallongeville, J.
Right arrow Articles by Staels, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dallongeville, J.
Right arrow Articles by Staels, B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Peroxisome Proliferator-activated Receptor alpha  Is Not Rate-limiting for the Lipoprotein-lowering Action of Fish Oil*

Jean DallongevilleDagger §, Eric BaugéDagger ||, Anne TailleuxDagger ||**, Jeffrey M. PetersDagger Dagger , Frank J. Gonzalez§§, Jean-Charles FruchartDagger ||**, and Bart StaelsDagger ||**

From the Dagger  Département d'Athérosclérose, § INSERM U-508, and || INSERM U-325, Institut Pasteur de Lille, 59019 Lille, France, ** Faculté de Pharmacie, Université Lille 2, 59000 Lille, France, Dagger Dagger  Center for Molecular Toxicology, the Pennsylvania State University, University Park, Pennsylvania 16802, and the §§ Laboratory of Molecular Carcinogenesis, NCI, National Institutes of Health, Bethesda, Maryland 20892

Similar to fibrate hypolipidemic drugs, long chain polyunsaturated fatty acids contained in fish oil are activators of peroxisome proliferator-activated receptor alpha  (PPARalpha ). The goal of this study was to assess the contribution of PPARalpha in mediating the effect of fish oil on plasma lipid, lipoprotein, and apolipoprotein levels. To this end, PPARalpha -deficient mice and wild-type littermates were fed isocaloric fish oil or coconut oil diets, the content of which varied reciprocally between 0, 3, 7, and 10% for 1 week. In both wild-type and PPARalpha -deficient mice, fish oil feeding was associated with a dose-dependent decrease in triglycerides, cholesterol, and phospholipids associated with lower levels of very low density lipoprotein (VLDL) triglycerides and high density lipoprotein (HDL) cholesterol. The lowering of triglycerides and VLDL triglycerides was associated with a significant decrease of plasma apoC-III in both genotypes. Fish oil treatment did not influence hepatic apoC-III mRNA levels in either genotype indicating that apoC-III is not under transcriptional control by fish oil. The lowering of HDL cholesterol observed in both genotypes was associated with reduced plasma apoA-II without changes in liver apoA-II mRNA levels. In contrast, plasma apoA-I and liver apoA-I mRNA levels were decreased in wild-type but not in PPARalpha -deficient mice after fish oil feeding indicating that PPARalpha contributes to the effect of fish oil on apoA-I gene expression. In conclusion, PPARalpha is not rate-limiting for fish oil to exert its triglyceride- and HDL-lowering action. Furthermore, PPARalpha mediates, at least partly, the decrease of apoA-I after fish oil treatment, whereas apoC-III and apoA-II levels are affected in a PPARalpha -independent manner. Altogether, these results show major molecular differences in action between fibrates and fish oil providing a molecular rationale for combination treatment with these compounds.

* This study was supported by INSERM and the Pasteur Institute of Lille.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed: Dépt. d'Athérosclérose, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, 59019 Lille Cedex, France. Tel.: 33 320 877 373; Fax: 33 320 877 360; E-mail: jean.dallongeville@pasteur-lille.fr.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
K. Vanschoonbeek, K. Wouters, P. E.J. van der Meijden, P. J. van Gorp, M. A.H. Feijge, M. Herfs, L. J. Schurgers, M. H. Hofker, M. P.M. de Maat, and J. W.M. Heemskerk
Anticoagulant Effect of Dietary Fish Oil in Hyperlipidemia: A Study of Hepatic Gene Expression in APOE2 Knock-in Mice
Arterioscler. Thromb. Vasc. Biol., November 1, 2008; 28(11): 2023 - 2029.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. C Chan, G. F Watts, M. N Nguyen, and P H. R Barrett
Factorial study of the effect of n-3 fatty acid supplementation and atorvastatin on the kinetics of HDL apolipoproteins A-I and A-II in men with abdominal obesity
Am. J. Clinical Nutrition, July 1, 2006; 84(1): 37 - 43.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
I. J. A. M. Jonkers, A. H. M. Smelt, H. M. G. Princen, F. Kuipers, J. A. Romijn, R. Boverhof, A. A. M. Masclee, and F. Stellaard
Fish Oil Increases Bile Acid Synthesis in Male Patients with Hypertriglyceridemia
J. Nutr., April 1, 2006; 136(4): 987 - 991.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
Y. Li, T. Y. Nara, and M. T. Nakamura
Peroxisome proliferator-activated receptor {alpha} is required for feedback regulation of highly unsaturated fatty acid synthesis
J. Lipid Res., November 1, 2005; 46(11): 2432 - 2440.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. S. Wright-Rodgers, M. K. Waldron, K. E. Bigley, G. E. Lees, and J. E. Bauer
Dietary Fatty Acids Alter Plasma Lipids and Lipoprotein Distributions in Dogs during Gestation, Lactation, and the Perinatal Period
J. Nutr., September 1, 2005; 135(9): 2230 - 2235.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
O. Olivieri, N. Martinelli, M. Sandri, A. Bassi, P. Guarini, E. Trabetti, F. Pizzolo, D. Girelli, S. Friso, P. F. Pignatti, et al.
Apolipoprotein C-III, n-3 Polyunsaturated Fatty Acids, and "Insulin-Resistant" T-455C APOC3 Gene Polymorphism in Heart Disease Patients: Example of Gene-Diet Interaction
Clin. Chem., February 1, 2005; 51(2): 360 - 367.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. J. Davidoff, M. M. Mason, M. B. Davidson, M. W. Carmody, K. K. Hintz, L. E. Wold, D. A. Podolin, and J. Ren
Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments
Am J Physiol Endocrinol Metab, May 1, 2004; 286(5): E718 - E724.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Sethi, O. Ziouzenkova, H. Ni, D. D. Wagner, J. Plutzky, and T. N. Mayadas
Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPARalpha
Blood, July 30, 2002; 100(4): 1340 - 1346.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
C. Vasandani, A. I. Kafrouni, A. Caronna, Y. Bashmakov, M. Gotthardt, J. D. Horton, and D. K. Spady
Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice
J. Lipid Res., May 1, 2002; 43(5): 772 - 784.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. B. Jump
The Biochemistry of n-3 Polyunsaturated Fatty Acids
J. Biol. Chem., March 8, 2002; 277(11): 8755 - 8758.
[Full Text] [PDF]

Home page
 J. Nutr.Home page
P.-M. Chao, C.-Y. Chao, F.-J. Lin, and C.-j. Huang
Oxidized Frying Oil Up-Regulates Hepatic Acyl-CoA Oxidase and Cytochrome P450 4 A1 Genes in Rats and Activates PPAR{alpha}
J. Nutr., December 1, 2001; 131(12): 3166 - 3174.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement