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J. Biol. Chem., Vol. 276, Issue 9, 6591-6604, March 2, 2001
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From the Immunoglobulin G (IgG) Fc receptors play a
critical role in linking IgG antibody-mediated immune responses with
cellular effector functions. A high resolution map of the binding site
on human IgG1 for human Fc
High Resolution Mapping of the Binding Site on Human
IgG1 for Fc
RI, FcRII, FcRIII, and FcRn and Design of IgG1
Variants with Improved Binding to the FcR*
,,,
,,,,, and**
Department of Immunology, the
§ Department of BioAnalytical Technology, the
¶ Department of Analytical Chemistry, and the Department of
Pharmacokinetics and Metabolism, Genentech, Inc.,
South San Francisco, California 94080
RI, FcRIIA, FcRIIB, FcRIIIA, and
FcRn receptors has been determined. A common set of IgG1 residues is
involved in binding to all FcR; FcRII and FcRIII also utilize
residues outside this common set. In addition to residues which, when
altered, abrogated binding to one or more of the receptors, several
residues were found that improved binding only to specific receptors or simultaneously improved binding to one type of receptor and reduced binding to another type. Select IgG1 variants with improved binding to
FcRIIIA exhibited up to 100% enhancement in
antibody-dependent cell cytotoxicity using human effector
cells; these variants included changes at residues not found at the
binding interface in the IgG/FcRIIIA co-crystal structure
(Sondermann, P., Huber, R., Oosthuizen, V., and Jacob, U. (2000)
Nature 406, 267-273). These engineered antibodies may have
important implications for improving antibody therapeutic efficacy.
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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|
|
|
 |
|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 A. Natsume, M. Wakitani, N. Yamane-Ohnuki, E. Shoji-Hosaka, R. Niwa, K. Uchida, M. Satoh, and K. Shitara Fucose Removal from Complex-Type Oligosaccharide Enhances the Antibody-Dependent Cellular Cytotoxicity of Single-Gene-Encoded Bispecific Antibody Comprising of Two Single-Chain Antibodies Linked to the Antibody Constant Region J. Biochem., September 1, 2006; 140(3): 359 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
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 |
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|
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|
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R. Niwa, E. Shoji-Hosaka, M. Sakurada, T. Shinkawa, K. Uchida, K. Nakamura, K. Matsushima, R. Ueda, N. Hanai, and K. Shitara Defucosylated Chimeric Anti-CC Chemokine Receptor 4 IgG1 with Enhanced Antibody-Dependent Cellular Cytotoxicity Shows Potent Therapeutic Activity to T-Cell Leukemia and Lymphoma Cancer Res., March 15, 2004; 64(6): 2127 - 2133. [Abstract] [Full Text] [PDF]
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P. R. Hinton, M. G. Johlfs, J. M. Xiong, K. Hanestad, K. C. Ong, C. Bullock, S. Keller, M. T. Tang, J. Y. Tso, M. Vasquez, et al. Engineered Human IgG Antibodies with Longer Serum Half-lives in Primates J. Biol. Chem., February 20, 2004; 279(8): 6213 - 6216. [Abstract] [Full Text] [PDF]
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W.-K. Weng and R. Levy Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma J. Clin. Oncol., November 1, 2003; 21(21): 3940 - 3947. [Abstract] [Full Text] [PDF]
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E. S. Ward, J. Zhou, V. Ghetie, and R. J. Ober Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans Int. Immunol., February 1, 2003; 15(2): 187 - 195. [Abstract] [Full Text] [PDF]
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M. Dechant, G. Vidarsson, B. Stockmeyer, R. Repp, M. J. Glennie, M. Gramatzki, J. G. J. van de Winkel, and T. Valerius Chimeric IgA antibodies against HLA class II effectively trigger lymphoma cell killing Blood, December 15, 2002; 100(13): 4574 - 4580. [Abstract] [Full Text] [PDF]
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W. F. D. Acqua, R. M. Woods, E. S. Ward, S. R. Palaszynski, N. K. Patel, Y. A. Brewah, H. Wu, P. A. Kiener, and S. Langermann Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences J. Immunol., November 1, 2002; 169(9): 5171 - 5180. [Abstract] [Full Text] [PDF]
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G. M. Spiekermann, P. W. Finn, E. S. Ward, J. Dumont, B. L. Dickinson, R. S. Blumberg, and W. I. Lencer Receptor-mediated Immunoglobulin G Transport Across Mucosal Barriers in Adult Life: Functional Expression of FcRn in the Mammalian Lung J. Exp. Med., August 5, 2002; 196(3): 303 - 310. [Abstract] [Full Text] [PDF]
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R. L. Shields, J. Lai, R. Keck, L. Y. O'Connell, K. Hong, Y. G. Meng, S. H. A. Weikert, and L. G. Presta Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human Fcgamma RIII and Antibody-dependent Cellular Toxicity J. Biol. Chem., July 19, 2002; 277(30): 26733 - 26740. [Abstract] [Full Text] [PDF]
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A. M. Kalergis and J. V. Ravetch Inducing Tumor Immunity through the Selective Engagement of Activating Fc{gamma} Receptors on Dendritic Cells J. Exp. Med., June 17, 2002; 195(12): 1653 - 1659. [Abstract] [Full Text] [PDF]
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A. J. da Silva, M. Brickelmaier, G. R. Majeau, Z. Li, L. Su, Y.-M. Hsu, and P. S. Hochman Alefacept, an Immunomodulatory Recombinant LFA-3/IgG1 Fusion Protein, Induces CD16 Signaling and CD2/CD16-Dependent Apoptosis of CD2+ Cells J. Immunol., May 1, 2002; 168(9): 4462 - 4471. [Abstract] [Full Text] [PDF]
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G. Cartron, L. Dacheux, G. Salles, P. Solal-Celigny, P. Bardos, P. Colombat, and H. Watier Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor Fcgamma RIIIa gene Blood, February 1, 2002; 99(3): 754 - 758. [Abstract] [Full Text] [PDF]
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R. J. Ober, C. G. Radu, V. Ghetie, and E. S. Ward Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies Int. Immunol., December 1, 2001; 13(12): 1551 - 1559. [Abstract] [Full Text] [PDF]
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Y. Mimura, P. Sondermann, R. Ghirlando, J. Lund, S. P. Young, M. Goodall, and R. Jefferis Role of Oligosaccharide Residues of IgG1-Fc in Fcgamma RIIb Binding J. Biol. Chem., November 30, 2001; 276(49): 45539 - 45547. [Abstract] [Full Text] [PDF]
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 O. W. Press, J. P. Leonard, B. Coiffier, R. Levy, and J. Timmerman Immunotherapy of Non-Hodgkin's Lymphomas Hematology, January 1, 2001; 2001(1): 221 - 240. [Abstract] [Full Text] [PDF]
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