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J. Biol. Chem., Vol. 277, Issue 1, 218-224, January 4, 2002
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,
,
,
¶, and
¶
**
From the In acute promyelocytic leukemia (APL) cells
harboring the promyelocytic leukemia retinoic acid receptor
Unité INSERM U417, Hôpital Saint
Antoine, 184 Rue du Faubourg Saint Antoine, 75012 Paris, France,
the § Brander Cancer Research Institute, New York Medical
College, Hawthorne, New York 10532, and the
Department of
Microbiology/Immunology, Kimmel Cancer Institute, Thomas Jefferson
University, Philadelphia, Pennsylvania 19107-5541
(PML-RAR
) chimeric protein, retinoic acid (RA)-induced
differentiation is triggered through a PML-RAR
signaling resulting
in activation of critical target genes. Induced differentiation of APL
cells is always preceded by withdrawal from the cell cycle and
commitment events leading to terminal differentiation. Here we have
identified the human ankyrin repeat-containing protein with a
suppressor of cytokine signaling box-2 (ASB-2) cDNA, as a novel
RA-induced gene in APL cells. PML-RAR
strongly enhanced RA-induced
ASB-2 mRNA expression. In myeloid leukemia cells, ASB-2 expression
induced growth inhibition and chromatin condensation recapitulating
early events critical to RA-induced differentiation of APL cells.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EBI Data Bank with accession number(s) AJ251238.
¶ These authors should be considered as equal last authors. ** To whom correspondence should be addressed: Unité INSERM U417, Hôpital Saint Antoine, 184 Rue du Faubourg Saint Antoine, 75012 Paris, France. Tel.: 33-1-49284613; Fax: 33-1-43406837; E-mail: cayre@st-antoine.inserm.fr.This article has been cited by other articles:
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