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J. Biol. Chem., Vol. 277, Issue 1, 327-337, January 4, 2002
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From the Institute for Biological Sciences, National Research
Council of Canada, 100 Sussex Dr.,
Ottawa, Ontario K1A 0R6, Canada
We have compared the lipo-oligosaccharide
(LOS) biosynthesis loci from 11 Campylobacter jejuni
strains expressing a total of 8 different ganglioside mimics in their
LOS outer cores. Based on the organization of the genes, the 11 corresponding loci could be classified into three classes, with one of
them being clearly an intermediate evolutionary step between the other
two. Comparative genomics and expression of specific
glycosyltransferases combined with in vitro activity assays
allowed us to identify at least five distinct mechanisms that allow
C. jejuni to vary the structure of the LOS outer core as
follows: 1) different gene complements; 2) phase variation because of
homopolymeric tracts; 3) gene inactivation by the deletion or insertion
of a single base (without phase variation); 4) single mutation leading
to the inactivation of a glycosyltransferase; and 5) single or multiple
mutations leading to "allelic" glycosyltransferases with different
acceptor specificities. The differences in the LOS outer core
structures expressed by the 11 C. jejuni strains examined
can be explained by one or more of the five mechanisms described in
this work.
The Genetic Bases for the Variation in the Lipo-oligosaccharide
of the Mucosal Pathogen, Campylobacter jejuni
BIOSYNTHESIS OF SIALYLATED GANGLIOSIDE MIMICS IN THE CORE
OLIGOSACCHARIDE*
,
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.: 613-991-9956;
Fax: 613-941-1327; E-mail: michel.gilbert@nrc.ca.
Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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