JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.C100442200 on November 13, 2001

J. Biol. Chem., Vol. 277, Issue 1, 9-12, January 4, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/1/9    most recent
C100442200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bae, M.-K.
Right arrow Articles by Kim, K.-W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bae, M.-K.
Right arrow Articles by Kim, K.-W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

ACCELERATED PUBLICATION
Jab1 Interacts Directly with HIF-1alpha and Regulates Its Stability*

Moon-Kyoung BaeDagger , Mee-Young AhnDagger , Joo-Won JeongDagger , Myung-Ho BaeDagger , You Mie LeeDagger , Soo-Kyung BaeDagger , Jong-Wan Park§, Kwang-Rok Kim, and Kyu-Won Kim||

From the Dagger  Department of Molecular Biology, Pusan National University, Pusan 609-735, Korea, the § Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea, and the  Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea

Hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that controls transcriptional activation of a number of genes responsive to the low cellular oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes. The stability and activity of HIF-1alpha are regulated by binding to various proteins such as pVHL, p53, and p300/CBP. Here, using the yeast two-hybrid screening system, we found that HIF-1alpha interacts with Jab1 (Jun activation domain-binding protein-1), which is a coactivator of AP-1 transcription factor and fifth subunit of COP9 signalosome complex. The interaction of Jab1 with HIF-1alpha was confirmed by GST pull-down assay and also reproduced in vivo in HEK 293 cells, where endogenous Jab1 was coimmunoprecipitated with the overexpressed HIF-1alpha . Moreover, Jab1-enhanced transcriptional activity of HIF-1 under hypoxia led to increase the expression of VEGF, a major HIF-1 target gene. Furthermore, Jab1 increased HIF-1alpha protein levels, which was due to the enhanced HIF-1alpha stability. The binding of HIF-1alpha and p53 tumor suppressor protein, negative regulator of HIF-1alpha stability, was interfered in a Jab1-dependent manner. Taken together, these results indicate that Jab1 should be considered as a novel regulator of HIF-1alpha stability via direct interaction.

* This work was supported by the National Research Laboratory Fund (2000-N-NL-01-C-015) from the Ministry of Science and Technology, Korea (to K.-W. K).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

|| To whom correspondence should be addressed: College of Pharmacy, Seoul National University, Seoul 151-742, Korea. Tel.: 82-2-880-6988; Fax: 82-2-872-1795; E-mail: qwonkim@plaza.snu.ac.kr.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
M.-C. Hsu, C.-C. Huang, H.-C. Chang, T.-H. Hu, and W.-C. Hung
Overexpression of Jab1 in Hepatocellular Carcinoma and Its Inhibition by Peroxisome Proliferator-Activated Receptor{gamma} Ligands In vitro and In vivo
Clin. Cancer Res., July 1, 2008; 14(13): 4045 - 4052.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Miyauchi, M. Kato, F. Tokunaga, and K. Iwai
The COP9/Signalosome Increases the Efficiency of von Hippel-Lindau Protein Ubiquitin Ligase-mediated Hypoxia-inducible Factor-{alpha} Ubiquitination
J. Biol. Chem., June 13, 2008; 283(24): 16622 - 16631.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. S. Adler, L. E. Littlepage, M. Lin, T. L.A. Kawahara, D. J. Wong, Z. Werb, and H. Y. Chang
CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression
Cancer Res., January 15, 2008; 68(2): 506 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
Y.-H. Hsieh, I.-J. Su, H.-C. Wang, J.-H. Tsai, Y.-J. Huang, W.-W. Chang, M.-D. Lai, H.-Y. Lei, and W. Huang
Hepatitis B Virus Pre-S2 Mutant Surface Antigen Induces Degradation of Cyclin-Dependent Kinase Inhibitor p27Kip1 through c-Jun Activation Domain-Binding Protein 1
Mol. Cancer Res., October 1, 2007; 5(10): 1063 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J.-H. Lim, J.-W. Park, S. J. Kim, M.-S. Kim, S.-K. Park, R. S. Johnson, and Y.-S. Chun
ATP6V0C Competes with Von Hippel-Lindau Protein in Hypoxia-Inducible Factor 1{alpha} (HIF-1{alpha}) Binding and Mediates HIF-1{alpha} Expression by Bafilomycin A1
Mol. Pharmacol., March 1, 2007; 71(3): 942 - 948.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Q. Ke and M. Costa
Hypoxia-Inducible Factor-1 (HIF-1)
Mol. Pharmacol., November 1, 2006; 70(5): 1469 - 1480.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Wang, C. Li, Y. Liu, W. Mei, S. Yu, C. Liu, L. Zhang, X. Cao, R. P. Kimberly, W. Grizzle, et al.
JAB1 Determines the Response of Rheumatoid Arthritis Synovial Fibroblasts to Tumor Necrosis Factor-{alpha}
Am. J. Pathol., September 1, 2006; 169(3): 889 - 902.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. J. Kang, H. J. Kim, J.-K. Rih, T. L. Mattson, K. W. Kim, C.-H. Cho, J. S. Isaacs, and I. Bae
BRCA1 Plays a Role in the Hypoxic Response by Regulating HIF-1{alpha} Stability and by Modulating Vascular Endothelial Growth Factor Expression
J. Biol. Chem., May 12, 2006; 281(19): 13047 - 13056.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Luo, Y. Wang, T. Hanck, R. Stricker, and G. Reiser
Jab1, a Novel Protease-activated Receptor-2 (PAR-2)-interacting Protein, Is Involved in PAR-2-induced Activation of Activator Protein-1
J. Biol. Chem., March 24, 2006; 281(12): 7927 - 7936.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. S. Richardson and W. Zundel
The Emerging Role of the COP9 Signalosome in Cancer
Mol. Cancer Res., December 1, 2005; 3(12): 645 - 653.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
R. H. Wenger, D. P. Stiehl, and G. Camenisch
Integration of Oxygen Signaling at the Consensus HRE
Sci. Signal., October 18, 2005; 2005(306): re12 - re12.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Y. Hong, J. H. Suh, K. Kim, E.-Y. Gong, S. H. Jeon, M. Ko, R. H. Seong, H. B. Kwon, and K. Lee
Modulation of Androgen Receptor Transactivation by the SWI3-Related Gene Product (SRG3) in Multiple Ways
Mol. Cell. Biol., June 15, 2005; 25(12): 4841 - 4852.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Tomoda, J.-y. Kato, E. Tatsumi, T. Takahashi, Y. Matsuo, and N. Yoneda-Kato
The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression
Blood, January 15, 2005; 105(2): 775 - 783.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Tomoda, N. Yoneda-Kato, A. Fukumoto, S. Yamanaka, and J.-y. Kato
Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice
J. Biol. Chem., October 8, 2004; 279(41): 43013 - 43018.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
A E Greijer and E van der Wall
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
J. Clin. Pathol., October 1, 2004; 57(10): 1009 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
L. Bemis, D. A. Chan, C. V. Finkielstein, L. Qi, P. D. Sutphin, X. Chen, K. Stenmark, A. J. Giaccia, and W. Zundel
Distinct aerobic and hypoxic mechanisms of HIF-{alpha} regulation by CSN5
Genes & Dev., April 1, 2004; 18(7): 739 - 744.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B.-C. Kim, H.-J. Lee, S. H. Park, S. R. Lee, T. S. Karpova, J. G. McNally, A. Felici, D. K. Lee, and S.-J. Kim
Jab1/CSN5, a Component of the COP9 Signalosome, Regulates Transforming Growth Factor {beta} Signaling by Binding to Smad7 and Promoting Its Degradation
Mol. Cell. Biol., March 15, 2004; 24(6): 2251 - 2262.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. A. Seta and D. E. Millhorn
Functional genomics approach to hypoxia signaling
J Appl Physiol, February 1, 2004; 96(2): 765 - 773.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. J. Esteva, A. A. Sahin, G. Z. Rassidakis, L. X. H. Yuan, T. L. Smith, Y. Yang, M. Z. Gilcrease, M. Cristofanilli, R. Nahta, L. Pusztai, et al.
Jun Activation Domain Binding Protein 1 Expression Is Associated with Low p27Kip1Levels in Node-Negative Breast Cancer
Clin. Cancer Res., November 15, 2003; 9(15): 5652 - 5659.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. Masson and P. J. Ratcliffe
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
J. Cell Sci., August 1, 2003; 116(15): 3041 - 3049.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. A. Kouvaraki, G. Z. Rassidakis, L. Tian, R. Kumar, C. Kittas, and F.-X. Claret
Jun Activation Domain-binding Protein 1 Expression in Breast Cancer Inversely Correlates with the Cell Cycle Inhibitor p27Kip1
Cancer Res., June 1, 2003; 63(11): 2977 - 2981.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. D. Emberley, Y. Niu, E. Leygue, L. Tomes, R. D. Gietz, L. C. Murphy, and P. H. Watson
Psoriasin Interacts with Jab1 and Influences Breast Cancer Progression
Cancer Res., April 15, 2003; 63(8): 1954 - 1961.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
R. H. WENGER
Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
FASEB J, August 1, 2002; 16(10): 1151 - 1162.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.