Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M109966200 on January 14, 2002

J. Biol. Chem., Vol. 277, Issue 12, 10037-10043, March 22, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/12/10037    most recent
M109966200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yagyu, H.
Right arrow Articles by Goldberg, I. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yagyu, H.
Right arrow Articles by Goldberg, I. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Very Low Density Lipoprotein (VLDL) Receptor-deficient Mice Have Reduced Lipoprotein Lipase Activity
POSSIBLE CAUSES OF HYPERTRIGLYCERIDEMIA AND REDUCED BODY MASS WITH VLDL RECEPTOR DEFICIENCY*

Hiroaki YagyuDagger §, E. Peer LutzDagger , Yuko KakoDagger , Steven MarksDagger , Yunying HuDagger , Sungshin Y. Choi, Andrè Bensadoun||, and Ira J. GoldbergDagger **

From the Dagger  Department of Medicine, Columbia University, New York, New York 10032,  Palo Alto Medical Foundation, Palo Alto, California 94301, and || Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853

Although very low density lipoprotein (VLDL) receptor (VLDLr) knockout mice have been reported to have no lipoprotein abnormalities, they develop less adipose tissue than control mice when fed a high calorie diet. Mice that are deficient in adipose tissue expression of lipoprotein lipase (LpL) also have less fat, but only when crossed with ob/ob mice. We hypothesized that the VLDLr, a protein that will bind and transport LpL, is required for optimal LpL actions in vivo and that hypertriglyceridemia due to VLDLr deficiency is exacerbated by either LpL deficiency or VLDL overproduction. Fasted VLDLr knockout (VLDLr0) mice were more hypertriglyceridemic than controls (2-fold greater triglyceride levels). The hypertriglyceridemia due to VLDLr0 was even more evident when VLDLr0 mice were crossed with heterozygous LpL-deficient (LpL1) and human apolipoprotein B (apoB) transgenic mice. This was due to an increase in apoB48-containing VLDL. [3H]VLDL turnover studies showed that VLDL-triglyceride clearance in VLDLr0/LpL1 mice was impaired by 50% compared with LpL1 mice. VLDLr0/LpL1 mice had less LpL activity in postheparin plasma, heart, and skeletal muscle. Infection of mice with an adenovirus-expressing receptor-associated protein, an inhibitor of the VLDLr, reduced LpL activity in wild type but not VLDLr0 mice. Therefore, the VLDLr is required for normal LpL regulation in vivo, and the disruption of VLDLr results in hypertriglyceridemia associated with decreased LpL activity.

* This work was supported by NHLBI, National Institutes of Health Grants HL45095 (to I. J. G.) and HL 14990 (to A. B.) and Deutsche Forschungsgemeinschaft Grant Ra914/1-1 (to E. P. L.). The atherosclerosis assays were performed with assistance for a core pathology laboratory supported by NIH Grant HL56984.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ Supported in part by a grant from the Japan Health Science Foundation.

** To whom correspondence should be addressed: Dept. of Medicine, Columbia University, 630 W. 168th St., New York, NY 10032. Tel.: 212-305-3678; Fax: 212-305-5384; E-mail: ijg3@columbia.edu.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
K. J. Williams
Some Things Just Have to Be Done In Vivo: GPIHBP1, Caloric Delivery, and the Generation of Remnant Lipoproteins
Arterioscler. Thromb. Vasc. Biol., June 1, 2009; 29(6): 792 - 795.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. Qiao, C. Zou, D. R. van der Westhuyzen, and J. Shao
Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism
Diabetes, July 1, 2008; 57(7): 1824 - 1833.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
D. C. Crawford, A. S. Nord, M. D. Badzioch, J. Ranchalis, L. A. McKinstry, M. Ahearn, C. Bertucci, C. Shephard, M. Wong, M. J. Rieder, et al.
A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk
J. Lipid Res., March 1, 2008; 49(3): 588 - 596.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. K. Kopec, D. R. Boverhof, L. D. Burgoon, D. Ibrahim-Aibo, J. R. Harkema, C. Tashiro, B. Chittim, and T. R. Zacharewski
Comparative Toxicogenomic Examination of the Hepatic Effects of PCB126 and TCDD in Immature, Ovariectomized C57BL/6 Mice
Toxicol. Sci., March 1, 2008; 102(1): 61 - 75.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. Gratten, A. J. Wilson, A. F. McRae, D. Beraldi, P. M. Visscher, J. M. Pemberton, and J. Slate
A Localized Negative Genetic Correlation Constrains Microevolution of Coat Color in Wild Sheep
Science, January 18, 2008; 319(5861): 318 - 320.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. M. Hofmann, D. Perez-Tilve, T. M. Greer, B. A. Coburn, E. Grant, J. E. Basford, M. H. Tschop, and D. Y. Hui
Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E Deficient Mice
Diabetes, January 1, 2008; 57(1): 5 - 12.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. Fergani, H. Oudart, J.-L. Gonzalez De Aguilar, B. Fricker, F. Rene, J.-F. Hocquette, V. Meininger, L. Dupuis, and J.-P. Loeffler
Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis
J. Lipid Res., July 1, 2007; 48(7): 1571 - 1580.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
C. Li, Z. Huang, R. Kingsley, X. Zhou, F. Li, D. W. Parke II, and W. Cao
Biochemical Alterations in the Retinas of Very Low-Density Lipoprotein Receptor Knockout Mice: An Animal Model of Retinal Angiomatous Proliferation
Arch Ophthalmol, June 1, 2007; 125(6): 795 - 803.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
P. Degrace, B. Moindrot, I. Mohamed, J. Gresti, Z.-Y. Du, J.-M. Chardigny, J.-L. Sebedio, and P. Clouet
Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid
J. Lipid Res., December 1, 2006; 47(12): 2647 - 2655.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
D. R. Boverhof, L. D. Burgoon, C. Tashiro, B. Sharratt, B. Chittim, J. R. Harkema, D. L. Mendrick, and T. R. Zacharewski
Comparative Toxicogenomic Analysis of the Hepatotoxic Effects of TCDD in Sprague Dawley Rats and C57BL/6 Mice
Toxicol. Sci., December 1, 2006; 94(2): 398 - 416.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Pulinilkunnil and B. Rodrigues
Cardiac lipoprotein lipase: Metabolic basis for diabetic heart disease
Cardiovasc Res, February 1, 2006; 69(2): 329 - 340.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Iwasaki, S. Takahashi, M. Takahashi, Y. Zenimaru, T. Kujiraoka, M. Ishihara, M. Nagano, J. Suzuki, I. Miyamori, H. Naiki, et al.
Deficiency of the Very Low-Density Lipoprotein (VLDL) Receptors in Streptozotocin-Induced Diabetic Rats: Insulin Dependency of the VLDL Receptor
Endocrinology, August 1, 2005; 146(8): 3286 - 3294.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S. M. S. E. Santo, P. C. N. Rensen, J. R. Goudriaan, A. Bensadoun, N. Bovenschen, P. J. Voshol, L. M. Havekes, and B. J. M. van Vlijmen
Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice
J. Lipid Res., June 1, 2005; 46(6): 1097 - 1102.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
I. Duivenvoorden, B. Teusink, P. C. Rensen, J. A. Romijn, L. M. Havekes, and P. J. Voshol
Apolipoprotein C3 Deficiency Results in Diet-Induced Obesity and Aggravated Insulin Resistance in Mice
Diabetes, March 1, 2005; 54(3): 664 - 671.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
J. F. P. Berbee, C. C. van der Hoogt, D. Sundararaman, L. M. Havekes, and P. C. N. Rensen
Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
J. Lipid Res., February 1, 2005; 46(2): 297 - 306.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
R. K. Vikramadithyan, Y. Kako, G. Chen, Y. Hu, E. Arikawa-Hirasawa, Y. Yamada, and I. J. Goldberg
Atherosclerosis in perlecan heterozygous mice
J. Lipid Res., October 1, 2004; 45(10): 1806 - 1812.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
J. R. Goudriaan, S. M. S. E. Santo, P. J. Voshol, B. Teusink, K. W. van Dijk, B. J. M. van Vlijmen, J. A. Romijn, L. M. Havekes, and P. C. N. Rensen
The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis
J. Lipid Res., August 1, 2004; 45(8): 1475 - 1481.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y.-G. Niu, D. Hauton, and R. D. Evans
Utilization of triacylglycerol-rich lipoproteins by the working rat heart: routes of uptake and metabolic fates
J. Physiol., July 1, 2004; 558(1): 225 - 237.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Augustus, H. Yagyu, G. Haemmerle, A. Bensadoun, R. K. Vikramadithyan, S.-Y. Park, J. K. Kim, R. Zechner, and I. J. Goldberg
Cardiac-specific Knock-out of Lipoprotein Lipase Alters Plasma Lipoprotein Triglyceride Metabolism and Cardiac Gene Expression
J. Biol. Chem., June 11, 2004; 279(24): 25050 - 25057.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Yokoyama, H. Yagyu, Y. Hu, T. Seo, K. Hirata, S. Homma, and I. J. Goldberg
Apolipoprotein B Production Reduces Lipotoxic Cardiomyopathy: STUDIES IN HEART-SPECIFIC LIPOPROTEIN LIPASE TRANSGENIC MOUSE
J. Biol. Chem., February 6, 2004; 279(6): 4204 - 4211.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Chiba, T. Nakazawa, K. Yui, E. Kaneko, and K. Shimokado
VLDL Induces Adipocyte Differentiation in ApoE-Dependent Manner
Arterioscler. Thromb. Vasc. Biol., August 1, 2003; 23(8): 1423 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Xia, A. D. Sniderman, and K. Cianflone
Acylation-stimulating Protein (ASP) Deficiency Induces Obesity Resistance and Increased Energy Expenditure in ob/ob Mice
J. Biol. Chem., November 22, 2002; 277(48): 45874 - 45879.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement