Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M111880200 on January 8, 2002

J. Biol. Chem., Vol. 277, Issue 12, 10379-10386, March 22, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/12/10379    most recent
M111880200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hasler, U.
Right arrow Articles by Martin, P.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hasler, U.
Right arrow Articles by Martin, P.-Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Long Term Regulation of Aquaporin-2 Expression in Vasopressin-responsive Renal Collecting Duct Principal Cells*

Udo HaslerDagger , David MordasiniDagger , Marcelle Bens§, Matthieu BianchiDagger , Françoise Cluzeaud§, Martine RousselotDagger , Alain Vandewalle§, Eric FérailleDagger ||, and Pierre-Yves MartinDagger ||

From the Dagger  Division of Nephrology, Fondation pour Recherches Médicales, 64 Avenue de la Roseraie, CH-1211, Genève 4, Switzerland and § INSERM U478, Faculté de Médecine Xavier Bichat, Institut Fédératif de Recherche 02, BP416, F-75870 Paris Cedex 18, France

Fine regulation of water reabsorption by the antidiuretic hormone [8-arginine]vasopressin (AVP) occurs in principal cells of the collecting duct and is largely dependent on regulation of the aquaporin-2 (AQP2) water channel. AVP-inducible long term AQP2 expression was investigated in immortalized mouse cortical collecting duct principal cells. Combined RNase protection assay, Western blot, and immunofluorescence analyses revealed that physiological concentrations of AVP added to the basal side, but not to the apical side, of cells grown on filters induced both AQP2 mRNA and apical protein expression. The stimulatory effect of AVP on AQP2 expression followed a V2 receptor-dependent pathway because [deamino-8-D-arginine]vasopressin (dDAVP), a specific V2 receptor agonist, produced the same effect as AVP, whereas the V2 antagonist SR121463B antagonized action of both AVP and dDAVP. Moreover, forskolin and cyclic 8-bromo-AMP fully reproduced the effects of AVP on AQP2 expression. Analysis of protein degradation pathways showed that inhibition of proteasomal activity prevented synthesis of AVP-inducible AQP2 mRNA and protein. Once synthesized, AQP2 protein was quickly degraded, a process that involves both the proteasomal and lysosomal pathways. This is the first study that delineates induction and degradation mechanisms of AQP2 endogenously expressed by a renal collecting duct principal cell line.

* This work was supported in part by the Swiss National Science Foundation Grant 31-56504.99 (to P.-Y. M.), by a grant from the Fondation Carlos et Elsie de Reuter (to P.-Y. M. and E. F.), by a grant from the Department of Medicine of Geneva University Hospital (to P.-Y. M.), and by INSERM.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed: INSERM U478, Faculté de Médecine Xavier Bichat, BP416, F-75870 Paris Cedex 18, France. Tel.: 33-1-44-85-63-21; Fax: 33-1-42-29-16-44; E-mail: vandewal@bichat.inserm.fr.

|| Both authors contributed equally to this work.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
U. Hasler, V. Leroy, P.-Y. Martin, and E. Feraille
Aquaporin-2 abundance in the renal collecting duct: new insights from cultured cell models
Am J Physiol Renal Physiol, July 1, 2009; 297(1): F10 - F18.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. S. P. Wildman, M. Boone, C. M. Peppiatt-Wildman, A. Contreras-Sanz, B. F. King, D. G. Shirley, P. M. T. Deen, and R. J. Unwin
Nucleotides Downregulate Aquaporin 2 via Activation of Apical P2 Receptors
J. Am. Soc. Nephrol., July 1, 2009; 20(7): 1480 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
B. W.M. van Balkom, M. Boone, G. Hendriks, E.-J. Kamsteeg, J. H. Robben, H. C. Stronks, A. van der Voorde, F. van Herp, P. van der Sluijs, and P. M.T. Deen
LIP5 Interacts with Aquaporin 2 and Facilitates Its Lysosomal Degradation
J. Am. Soc. Nephrol., May 1, 2009; 20(5): 990 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
U. Hasler
Controlled aquaporin-2 expression in the hypertonic environment
Am J Physiol Cell Physiol, April 1, 2009; 296(4): C641 - C653.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. R. Soria, S. A. Gradilone, M. C. Larocca, and R. A. Marinelli
Glucagon induces the gene expression of aquaporin-8 but not that of aquaporin-9 water channels in the rat hepatocyte
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1274 - R1281.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M.-J. Yu, R. L. Miller, P. Uawithya, M. M. Rinschen, S. Khositseth, D. W. W. Braucht, C.-L. Chou, T. Pisitkun, R. D. Nelson, and M. A. Knepper
Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct
PNAS, February 17, 2009; 106(7): 2441 - 2446.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
V. Leroy, S. De Seigneux, V. Agassiz, U. Hasler, M.-E. Rafestin-Oblin, M. Vinciguerra, P.-Y. Martin, and E. Feraille
Aldosterone Activates NF-{kappa}B in the Collecting Duct
J. Am. Soc. Nephrol., January 1, 2009; 20(1): 131 - 144.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. Nunes, U. Hasler, M. McKee, H. A. J. Lu, R. Bouley, and D. Brown
A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2
Am J Physiol Cell Physiol, December 1, 2008; 295(6): C1476 - C1487.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
U. Hasler, V. Leroy, U. S. Jeon, R. Bouley, M. Dimitrov, J. A. Kim, D. Brown, H. M. Kwon, P.-Y. Martin, and E. Feraille
NF-{kappa}B Modulates Aquaporin-2 Transcription in Renal Collecting Duct Principal Cells
J. Biol. Chem., October 17, 2008; 283(42): 28095 - 28105.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Boulkroun, D. Ruffieux-Daidie, J.-J. Vitagliano, O. Poirot, R.-P. Charles, D. Lagnaz, D. Firsov, S. Kellenberger, and O. Staub
Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3
Am J Physiol Renal Physiol, October 1, 2008; 295(4): F889 - F900.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Combet, S. Gouraud, R. Gobin, V. Berthonaud, G. Geelen, B. Corman, and J.-M. Verbavatz
Aquaporin-2 downregulation in kidney medulla of aging rats is posttranscriptional and is abolished by water deprivation
Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1408 - F1414.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
G. L. Lehmann, F. I. Carreras, L. R. Soria, S. A. Gradilone, and R. A. Marinelli
LPS induces the TNF-{alpha}-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis
Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G567 - G575.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Bustamante, U. Hasler, V. Leroy, S. de Seigneux, M. Dimitrov, D. Mordasini, M. Rousselot, P.-Y. Martin, and E. Feraille
Calcium-sensing Receptor Attenuates AVP-induced Aquaporin-2 Expression via a Calmodulin-dependent Mechanism
J. Am. Soc. Nephrol., January 1, 2008; 19(1): 109 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
F. I. Carreras, G. L. Lehmann, D. Ferri, M. F. Tioni, G. Calamita, and R. A. Marinelli
Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis
Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G905 - G912.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. H. Robben, N. V. A. M. Knoers, and P. M. T. Deen
Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus.
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F257 - F270.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
U. Hasler, U. S. Jeon, J. A. Kim, D. Mordasini, H. M. Kwon, E. Feraille, and P.-Y. Martin
Tonicity-Responsive Enhancer Binding Protein Is an Essential Regulator of Aquaporin-2 Expression in Renal Collecting Duct Principal Cells
J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1521 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. G. Bichet
Lithium, Cyclic AMP Signaling, A-Kinase Anchoring Proteins, and Aquaporin-2
J. Am. Soc. Nephrol., April 1, 2006; 17(4): 920 - 922.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Li, S. Shaw, E.-J. Kamsteeg, A. Vandewalle, and P. M.T. Deen
Development of Lithium-Induced Nephrogenic Diabetes Insipidus Is Dissociated from Adenylyl Cyclase Activity
J. Am. Soc. Nephrol., April 1, 2006; 17(4): 1063 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
U. Hasler, S. Nielsen, E. Feraille, and P.-Y. Martin
Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells
Am J Physiol Renal Physiol, January 1, 2006; 290(1): F177 - F187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Mordasini, M. Bustamante, M. Rousselot, P.-Y. Martin, U. Hasler, and E. Feraille
Stimulation of Na+ transport by AVP is independent of PKA phosphorylation of the Na-K-ATPase in collecting duct principal cells
Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1031 - F1039.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Vinciguerra, U. Hasler, D. Mordasini, M. Roussel, M. Capovilla, E. Ogier-Denis, A. Vandewalle, P.-Y. Martin, and E. Feraille
Cytokines and Sodium Induce Protein Kinase A-Dependent Cell-Surface Na,K-ATPase Recruitment via Dissociation of NF-{kappa}B/I{kappa}B/Protein Kinase A Catalytic Subunit Complex in Collecting Duct Principal Cells
J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2576 - 2585.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
U. Hasler, M. Vinciguerra, A. Vandewalle, P.-Y. Martin, and E. Feraille
Dual Effects of Hypertonicity on Aquaporin-2 Expression in Cultured Renal Collecting Duct Principal Cells
J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1571 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Bustamante, U. Hasler, O. Kotova, A. V. Chibalin, D. Mordasini, M. Rousselot, A. Vandewalle, P.-Y. Martin, and E. Feraille
Insulin potentiates AVP-induced AQP2 expression in cultured renal collecting duct principal cells
Am J Physiol Renal Physiol, February 1, 2005; 288(2): F334 - F344.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
P. A. Sonalker, S. P. Tofovic, and E. K. Jackson
Increased Expression of the Sodium Transporter BSC-1 in Spontaneously Hypertensive Rats
J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1052 - 1061.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Vinciguerra, S. Arnaudeau, D. Mordasini, M. Rousselot, M. Bens, A. Vandewalle, P.-Y. Martin, U. Hasler, and E. Feraille
Extracellular Hypotonicity Increases Na,K-ATPase Cell Surface Expression via Enhanced Na+ Influx in Cultured Renal Collecting Duct Cells
J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2537 - 2547.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Hadrup, J. S. Petersen, J. Praetorius, E. Meier, M. Graebe, L. Brond, D. Staahltoft, S. Nielsen, S. Christensen, D. R. Kapusta, et al.
Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation
Am J Physiol Renal Physiol, July 1, 2004; 287(1): F160 - F168.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Arima, N. Yamamoto, K. Sobue, F. Umenishi, T. Tada, H. Katsuya, and K. Asai
Hyperosmolar Mannitol Stimulates Expression of Aquaporins 4 and 9 through a p38 Mitogen-activated Protein Kinase-dependent Pathway in Rat Astrocytes
J. Biol. Chem., November 7, 2003; 278(45): 44525 - 44534.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Hirano, C. Zuber, J. Roth, and M. Ziak
The Proteasome Is Involved in the Degradation of Different Aquaporin-2 Mutants Causing Nephrogenic Diabetes Insipidus
Am. J. Pathol., July 1, 2003; 163(1): 111 - 120.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Vinciguerra, G. Deschenes, U. Hasler, D. Mordasini, M. Rousselot, A. Doucet, A. Vandewalle, P.-Y. Martin, and E. Feraille
Intracellular Na+ Controls Cell Surface Expression of Na,K-ATPase via a cAMP-independent PKA Pathway in Mammalian Kidney Collecting Duct Cells
Mol. Biol. Cell, July 1, 2003; 14(7): 2677 - 2688.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M.-E. Rafestin-Oblin, J. Fagart, A. Souque, C. Seguin, M. Bens, and A. Vandewalle
11beta -Hydroxyprogesterone Acts as a Mineralocorticoid Agonist in Stimulating Na+ Absorption in Mammalian Principal Cortical Collecting Duct Cells
Mol. Pharmacol., December 1, 2002; 62(6): 1306 - 1313.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement