| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 277, Issue 12, 9749-9756, March 22, 2002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Burnham Institute, La Jolla, California 92037
Recently, we have shown that membrane type 1 matrix metalloproteinase (MT1-MMP) exhibits integrin convertase
activity. Similar to furin-like proprotein convertases, MT1-MMP
directly processes a single chain precursor of
Processing of Integrin
v Subunit by Membrane Type
1 Matrix Metalloproteinase Stimulates Migration of Breast Carcinoma
Cells on Vitronectin and Enhances Tyrosine Phosphorylation of Focal
Adhesion Kinase*
v
integrin subunit (pro-v) into the heavy and light
-chains connected by a disulfide bridge. To evaluate functionality
of MT1-MMP-processed integrins, we examined breast carcinoma MCF7 cells
co-expressing v
3 integrin with either the
wild type or mutant MT1-MMP in a variety of migration and adhesion
tests. Specific inhibitors of proprotein convertases and MMP were
employed in our cell system to attenuate the individual pathways of
pro-v maturation. We present evidence that MT1-MMP cleavage of pro-v in the cells did not affect RGD-ligand
binding of the resulting v3 integrin but
enhanced outside-in signal transduction through a focal adhesion kinase
pathway. Enhanced tyrosine phosphorylation of focal adhesion kinase in
cells co-expressing MT1-MMP and v3
integrin contributed to efficient adhesion and, especially, migration
of cells on vitronectin, a ligand of v3 integrin. These mechanisms underscore the significance of a coordinated interplay between MT1-MMP and v3 integrin
in tumor cells and identify downstream signaling pathways resulting
from their interactions. Regulation of integrin maturation and
functionality may be an important role of MT1-MMP in tumor cells.
*
This work was supported by National Institutes of Health
Grants CA83017 and CA77470, California Breast Cancer Research Program Grant 5JB0094, and Susan G. Komen Breast Cancer Foundation Grant 9849 (to A. Y. S.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: The Burnham Institute,
10901 North Torrey Pines Rd., La Jolla, CA 92037. Tel.: 858-646-3100, Ext. 3255; Fax: 858-646-3192; E-mail: strongin@burnham.org.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. J. Wilson, K. C. Nannuru, M. Futakuchi, A. Sadanandam, and R. K. Singh Cathepsin G Enhances Mammary Tumor-Induced Osteolysis by Generating Soluble Receptor Activator of Nuclear Factor-{kappa}B Ligand Cancer Res., July 15, 2008; 68(14): 5803 - 5811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takai, K. Kitano, S.-i. Terawaki, R. Maesaki, and T. Hakoshima Structural basis of PSGL-1 binding to ERM proteins. Genes Cells, December 1, 2007; 12(12): 1329 - 1338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Savinov, D. V. Rozanov, and A. Y. Strongin Mechanistic insights into targeting T cell membrane proteinase to promote islet {beta}-cell rejuvenation in type 1 diabetes FASEB J, September 1, 2006; 20(11): 1793 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Ikonomidis, J. A. Jones, J. R. Barbour, R. E. Stroud, L. L. Clark, B. S. Kaplan, A. Zeeshan, J. E. Bavaria, J. H. Gorman III, F. G. Spinale, et al. Expression of Matrix Metalloproteinases and Endogenous Inhibitors Within Ascending Aortic Aneurysms of Patients With Marfan Syndrome Circulation, July 4, 2006; 114(1_suppl): I-365 - I-370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Remacle, A. V. Chekanov, V. S. Golubkov, A. Y. Savinov, D. V. Rozanov, and A. Y. Strongin O-Glycosylation Regulates Autolysis of Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) J. Biol. Chem., June 23, 2006; 281(25): 16897 - 16905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Rozanov, A. Y. Savinov, V. S. Golubkov, S. Tomlinson, and A. Y. Strongin Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. Cancer Res., June 15, 2006; 66(12): 6258 - 6263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. W.M. van Hinsbergh, M. A. Engelse, and P. H.A. Quax Pericellular Proteases in Angiogenesis and Vasculogenesis Arterioscler. Thromb. Vasc. Biol., April 1, 2006; 26(4): 716 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lafleur, F. A. Mercuri, N. Ruangpanit, M. Seiki, H. Sato, and E. W. Thompson Type I Collagen Abrogates the Clathrin-mediated Internalization of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) via the MT1-MMP Hemopexin Domain J. Biol. Chem., March 10, 2006; 281(10): 6826 - 6840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Covington, R. C. Burghardt, and A. R. Parrish Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14) Am J Physiol Renal Physiol, January 1, 2006; 290(1): F43 - F51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Deryugina, A. Zijlstra, J. J. Partridge, T. A. Kupriyanova, M. A. Madsen, T. Papagiannakopoulos, and J. P. Quigley Unexpected Effect of Matrix Metalloproteinase Down-Regulation on Vascular Intravasation and Metastasis of Human Fibrosarcoma Cells Selected In vivo for High Rates of Dissemination Cancer Res., December 1, 2005; 65(23): 10959 - 10969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Remacle, D. V. Rozanov, P. C. Baciu, A. V. Chekanov, V. S. Golubkov, and A. Y. Strongin The transmembrane domain is essential for the microtubular trafficking of membrane type-1 matrix metalloproteinase (MT1-MMP) J. Cell Sci., November 1, 2005; 118(21): 4975 - 4984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Nisato, G. Hosseini, C. Sirrenberg, G. S. Butler, T. Crabbe, A. J.P. Docherty, M. Wiesner, G. Murphy, C. M. Overall, S. L. Goodman, et al. Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin {alpha}v{beta}3 in Angiogenesis In vitro: Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and {alpha}v{beta}3 Are Critical Cancer Res., October 15, 2005; 65(20): 9377 - 9387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Osenkowski, S. O. Meroueh, D. Pavel, S. Mobashery, and R. Fridman Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing J. Biol. Chem., July 15, 2005; 280(28): 26160 - 26168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Robinet, A. Fahem, J.-H. Cauchard, E. Huet, L. Vincent, S. Lorimier, F. Antonicelli, C. Soria, M. Crepin, W. Hornebeck, et al. Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP J. Cell Sci., January 15, 2005; 118(2): 343 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mazzone, M. Baldassarre, G. Beznoussenko, G. Giacchetti, J. Cao, S. Zucker, A. Luini, and R. Buccione Intracellular processing and activation of membrane type 1 matrix metalloprotease depends on its partitioning into lipid domains J. Cell Sci., December 15, 2004; 117(26): 6275 - 6287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wang, J. Nie, and D. Pei The Hemopexin Domain of Membrane-type Matrix Metalloproteinase-1 (MT1-MMP) Is Not Required for Its Activation of proMMP2 on Cell Surface but Is Essential for MT1-MMP-mediated Invasion in Three-dimensional Type I Collagen J. Biol. Chem., December 3, 2004; 279(49): 51148 - 51155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Rozanov, S. Sikora, A. Godzik, T. I. Postnova, V. Golubkov, A. Savinov, S. Tomlinson, and A. Y. Strongin Non-proteolytic, Receptor/Ligand Interactions Associate Cellular Membrane Type-1 Matrix Metalloproteinase with the Complement Component C1q J. Biol. Chem., November 26, 2004; 279(48): 50321 - 50328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Rozanov, A. Y. Savinov, V. S. Golubkov, T. I. Postnova, A. Remacle, S. Tomlinson, and A. Y. Strongin Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Cleaves C3b, an Essential Component of the Complement System J. Biol. Chem., November 5, 2004; 279(45): 46551 - 46557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nejjari, V. Berthet, V. Rigot, S. Laforest, M.-F. Jacquier, N. G. Seidah, L. Remy, E. Bruyneel, J.-Y. Scoazec, J. Marvaldi, et al. Inhibition of Proprotein Convertases Enhances Cell Migration and Metastases Development of Human Colon Carcinoma Cells in a Rat Model Am. J. Pathol., June 1, 2004; 164(6): 1925 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Sounni, C. Roghi, V. Chabottaux, M. Janssen, C. Munaut, E. Maquoi, B. G. Galvez, C. Gilles, F. Frankenne, G. Murphy, et al. Up-regulation of Vascular Endothelial Growth Factor-A by Active Membrane-type 1 Matrix Metalloproteinase through Activation of Src-Tyrosine Kinases J. Biol. Chem., April 2, 2004; 279(14): 13564 - 13574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cao, P. Kozarekar, M. Pavlaki, C. Chiarelli, W. F. Bahou, and S. Zucker Distinct Roles for the Catalytic and Hemopexin Domains of Membrane Type 1-Matrix Metalloproteinase in Substrate Degradation and Cell Migration J. Biol. Chem., April 2, 2004; 279(14): 14129 - 14139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Bartolome, B. G. Galvez, N. Longo, F. Baleux, G. N. P. van Muijen, P. Sanchez-Mateos, A. G. Arroyo, and J. Teixido Stromal Cell-Derived Factor-1{alpha} Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities Cancer Res., April 1, 2004; 64(7): 2534 - 2543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Stawowy, H. Kallisch, J. P. Veinot, A. Kilimnik, W. Prichett, S. Goetze, N. G. Seidah, M. Chretien, E. Fleck, and K. Graf Endoproteolytic Activation of {alpha}v Integrin by Proprotein Convertase PC5 Is Required for Vascular Smooth Muscle Cell Adhesion to Vitronectin and Integrin-Dependent Signaling Circulation, February 17, 2004; 109(6): 770 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Rozanov, E. Hahn-Dantona, D. K. Strickland, and A. Y. Strongin The Low Density Lipoprotein Receptor-related Protein LRP Is Regulated by Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Proteolysis in Malignant Cells J. Biol. Chem., February 6, 2004; 279(6): 4260 - 4268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Guo and L. Piacentini Type I Collagen-induced MMP-2 Activation Coincides with Up-regulation of Membrane Type 1-Matrix Metalloproteinase and TIMP-2 in Cardiac Fibroblasts J. Biol. Chem., November 21, 2003; 278(47): 46699 - 46708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jiang and D. Pei Distinct Roles of Catalytic and Pexin-like Domains in Membrane-type Matrix Metalloproteinase (MMP)-mediated Pro-MMP-2 Activation and Collagenolysis J. Biol. Chem., October 3, 2003; 278(40): 38765 - 38771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Remacle, G. Murphy, and C. Roghi Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface J. Cell Sci., October 1, 2003; 116(19): 3905 - 3916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rolli, E. Fransvea, J. Pilch, A. Saven, and B. Felding-Habermann Activated integrin {alpha}v{beta}3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells PNAS, August 5, 2003; 100(16): 9482 - 9487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Palmieri, S. Poggi, V. Ulivi, G. Casartelli, and P. Manduca Pro-collagen I COOH-terminal Trimer Induces Directional Migration and Metalloproteinases in Breast Cancer Cells J. Biol. Chem., January 31, 2003; 278(6): 3639 - 3647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Spinale Bioactive Peptide Signaling Within the Myocardial Interstitium and the Matrix Metalloproteinases Circ. Res., December 13, 2002; 91(12): 1082 - 1084. [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Galvez, S. Matias-Roman, M. Yanez-Mo, F. Sanchez-Madrid, and A. G. Arroyo ECM regulates MT1-MMP localization with {beta}1 or {alpha}v{beta}3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells J. Cell Biol., November 7, 2002; 159(3): 509 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Toth, S. Hernandez-Barrantes, P. Osenkowski, M. M. Bernardo, D. C. Gervasi, Y. Shimura, O. Meroueh, L. P. Kotra, B. G. Galvez, A. G. Arroyo, et al. Complex Pattern of Membrane Type 1 Matrix Metalloproteinase Shedding. REGULATION BY AUTOCATALYTIC CELL SURFACE INACTIVATION OF ACTIVE ENZYME J. Biol. Chem., July 12, 2002; 277(29): 26340 - 26350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Galt, S. Lindemann, L. Allen, D. J. Medd, J. M. Falk, T. M. McIntyre, S. M. Prescott, L. W. Kraiss, G. A. Zimmerman, and A. S. Weyrich Outside-In Signals Delivered by Matrix Metalloproteinase-1 Regulate Platelet Function Circ. Res., May 31, 2002; 90(10): 1093 - 1099. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
