| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 277, Issue 14, 11621-11624, April 5, 2002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
,¶
From the Histone N-terminal tails are post-translationally
modified in many ways. At lysine residues, histones can be either
acetylated or methylated. Both modifications lead to the binding of
specific proteins; bromodomain proteins, such as GCN5, bind acetyl
lysines and the chromodomain protein, HP1, binds methyl lysine 9 of
histone H3. Here we show that the previously characterized
transcriptional repressor complex NuRD (nucleosome
remodeling and deacetylase) binds to the
histone H3 N-terminal tail and that methylation at lysine 4, but not
lysine 9, prevents binding. Given that lysine 4 methylation is found at
sites of active transcription, these results suggest that a function of
lysine 4 methylation is to disrupt the association of histones with a
repressor complex.
Wellcome/Cancer Research
UK Institute, Tennis Court Rd., Cambridge CB2 1QR and the
§ MRC Chemical Research Centre, Hammersmith Hospital,
Du Cane Road, London W12 0NN, United Kingdom
This article has been cited by other articles:
|
|
 |
|
  W. Walter, D. Clynes, Y. Tang, R. Marmorstein, J. Mellor, and S. L. Berger 14-3-3 Interaction with Histone H3 Involves a Dual Modification Pattern of Phosphoacetylation Mol. Cell. Biol., April 15, 2008; 28(8): 2840 - 2849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Karagianni, L. Amazit, J. Qin, and J. Wong ICBP90, a Novel Methyl K9 H3 Binding Protein Linking Protein Ubiquitination with Heterochromatin Formation Mol. Cell. Biol., January 15, 2008; 28(2): 705 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Lauberth, A. C. Bilyeu, B. A. Firulli, K. L. Kroll, and M. Rauchman A Phosphomimetic Mutation in the Sall1 Repression Motif Disrupts Recruitment of the Nucleosome Remodeling and Deacetylase Complex and Repression of Gbx2 J. Biol. Chem., November 30, 2007; 282(48): 34858 - 34868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Ivanov, T. Ivanova, J. Kurash, A. Ivanov, S. Chuikov, F. Gizatullin, E. M. Herrera-Medina, F. Rauscher III, D. Reinberg, and N. A. Barlev Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage Mol. Cell. Biol., October 1, 2007; 27(19): 6756 - 6769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Hwang, K. Y. Song, C. S. Kim, H. S. Choi, X.-H. Guo, P.-Y. Law, L.-N. Wei, and H. H. Loh Evidence of Endogenous Mu Opioid Receptor Regulation by Epigenetic Control of the Promoters Mol. Cell. Biol., July 1, 2007; 27(13): 4720 - 4736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Carchilan, M. Delgado, T. Ribeiro, P. Costa-Nunes, A. Caperta, L. Morais-Cecilio, R. N. Jones, W. Viegas, and A. Houben Transcriptionally Active Heterochromatin in Rye B Chromosomes PLANT CELL, June 1, 2007; 19(6): 1738 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Heo, B. Kim, K. Kim, J. Choi, H. Kim, Y. Zhan, J. A. Ranish, and W. An Isolation and Characterization of Proteins Associated with Histone H3 Tails in Vivo J. Biol. Chem., May 25, 2007; 282(21): 15476 - 15483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Imhof Epigenetic regulators and histone modification Brief Funct Genomic Proteomic, September 1, 2006; 5(3): 222 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Suka, E. Nakashima, K. Shinmyozu, M. Hidaka, and H. Jingami The WD40-repeat protein Pwp1p associates in vivo with 25S ribosomal chromatin in a histone H4 tail-dependent manner Nucleic Acids Res., July 19, 2006; 34(12): 3555 - 3567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sharma, N. K. Saxena, N. E. Davidson, and P. M. Vertino Restoration of Tamoxifen Sensitivity in Estrogen Receptor-Negative Breast Cancer Cells: Tamoxifen-Bound Reactivated ER Recruits Distinctive Corepressor Complexes. Cancer Res., June 15, 2006; 66(12): 6370 - 6378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Sims III, C.-F. Chen, H. Santos-Rosa, T. Kouzarides, S. S. Patel, and D. Reinberg Human but Not Yeast CHD1 Binds Directly and Selectively to Histone H3 Methylated at Lysine 4 via Its Tandem Chromodomains J. Biol. Chem., December 23, 2005; 280(51): 41789 - 41792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Mahajan, G. J. Narlikar, G. Boyapaty, R. E. Kingston, and S. M. Weissman Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the {beta}-globin locus control region PNAS, October 18, 2005; 102(42): 15012 - 15017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Karnik, C. M. Hughes, X. Gu, O. Rozenblatt-Rosen, G. W. McLean, Y. Xiong, M. Meyerson, and S. K. Kim Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c PNAS, October 11, 2005; 102(41): 14659 - 14664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Chan, J. E. Fish, I. A. Mawji, D. D. Leung, A. C. Rachlis, and P. A. Marsden Epigenetic Basis for the Transcriptional Hyporesponsiveness of the Human Inducible Nitric Oxide Synthase Gene in Vascular Endothelial Cells J. Immunol., September 15, 2005; 175(6): 3846 - 3861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. van Dijk, K. E. Marley, B.-r. Jeong, J. Xu, J. Hesson, R. L. Cerny, J. H. Waterborg, and H. Cerutti Monomethyl Histone H3 Lysine 4 as an Epigenetic Mark for Silenced Euchromatin in Chlamydomonas PLANT CELL, September 1, 2005; 17(9): 2439 - 2453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Fish, C. C. Matouk, A. Rachlis, S. Lin, S. C. Tai, C. D'Abreo, and P. A. Marsden The Expression of Endothelial Nitric-oxide Synthase Is Controlled by a Cell-specific Histone Code J. Biol. Chem., July 1, 2005; 280(26): 24824 - 24838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Melnick, K. Adelson, and J. D. Licht The Theoretical Basis of Transcriptional Therapy of Cancer: Can It Be Put Into Practice? J. Clin. Oncol., June 10, 2005; 23(17): 3957 - 3970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Stewart, J. Li, and J. Wong Relationship between Histone H3 Lysine 9 Methylation, Transcription Repression, and Heterochromatin Protein 1 Recruitment Mol. Cell. Biol., April 1, 2005; 25(7): 2525 - 2538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Y. Lee, C. Teyssier, B. D. Strahl, and M. R. Stallcup Role of Protein Methylation in Regulation of Transcription Endocr. Rev., April 1, 2005; 26(2): 147 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kon, K. M. Cadigan, S. L. da Silva, and R. Nusse Developmental Roles of the Mi-2/NURD-Associated Protein p66 in Drosophila Genetics, April 1, 2005; 169(4): 2087 - 2100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Cheung and P. Lau Epigenetic Regulation by Histone Methylation and Histone Variants Mol. Endocrinol., March 1, 2005; 19(3): 563 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Pietrobono, E. Tabolacci, F. Zalfa, I. Zito, A. Terracciano, U. Moscato, C. Bagni, B. Oostra, P. Chiurazzi, and G. Neri Molecular dissection of the events leading to inactivation of the FMR1 gene Hum. Mol. Genet., January 15, 2005; 14(2): 267 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Johnson, S. Mollah, B. A. Garcia, T. L. Muratore, J. Shabanowitz, D. F. Hunt, and S. E. Jacobsen Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications Nucleic Acids Res., December 14, 2004; 32(22): 6511 - 6518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Kang, O. A. Janne, and J. J. Palvimo Coregulator Recruitment and Histone Modifications in Transcriptional Regulation by the Androgen Receptor Mol. Endocrinol., November 1, 2004; 18(11): 2633 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Sims III, R. Belotserkovskaya, and D. Reinberg Elongation by RNA polymerase II: the short and long of it Genes & Dev., October 15, 2004; 18(20): 2437 - 2468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamashita, R. Shinnakasu, Y. Nigo, M. Kimura, A. Hasegawa, M. Taniguchi, and T. Nakayama Interleukin (IL)-4-independent Maintenance of Histone Modification of the IL-4 Gene Loci in Memory Th2 Cells J. Biol. Chem., September 17, 2004; 279(38): 39454 - 39464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rastegar, L. Kobrossy, E. N. Kovacs, I. Rambaldi, and M. Featherstone Sequential Histone Modifications at Hoxd4 Regulatory Regions Distinguish Anterior from Posterior Embryonic Compartments Mol. Cell. Biol., September 15, 2004; 24(18): 8090 - 8103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Cha-Molstad, D. M. Keller, G. S. Yochum, S. Impey, and R. H. Goodman Cell-type-specific binding of the transcription factor CREB to the cAMP-response element PNAS, September 14, 2004; 101(37): 13572 - 13577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nishio and M. J. Walsh CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription PNAS, August 3, 2004; 101(31): 11257 - 11262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Kutney, R. Hong, T. Macfarlan, and D. Chakravarti A Signaling Role of Histone-binding Proteins and INHAT Subunits pp32 and Set/TAF-I{beta} in Integrating Chromatin Hypoacetylation and Transcriptional Repression J. Biol. Chem., July 16, 2004; 279(29): 30850 - 30855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamashita, M. Ukai-Tadenuma, T. Miyamoto, K. Sugaya, H. Hosokawa, A. Hasegawa, M. Kimura, M. Taniguchi, J. DeGregori, and T. Nakayama Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci J. Biol. Chem., June 25, 2004; 279(26): 26983 - 26990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schneider, A. J. Bannister, C. Weise, and T. Kouzarides Direct Binding of INHAT to H3 Tails Disrupted by Modifications J. Biol. Chem., June 4, 2004; 279(23): 23859 - 23862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Kiekhaefer, M. E. Boyer, K. D. Johnson, and E. H. Bresnick A WW Domain-binding Motif within the Activation Domain of the Hematopoietic Transcription Factor NF-E2 Is Essential for Establishment of a Tissue-specific Histone Modification Pattern J. Biol. Chem., February 27, 2004; 279(9): 7456 - 7461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Fass, J. E. F. Butler, and R. H. Goodman Deacetylase Activity Is Required for cAMP Activation of a Subset of CREB Target Genes J. Biol. Chem., October 31, 2003; 278(44): 43014 - 43019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. van Driel, P. F. Fransz, and P. J. Verschure The eukaryotic genome: a system regulated at different hierarchical levels J. Cell Sci., October 15, 2003; 116(20): 4067 - 4075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Chakrabarti, J. Francis, S. M. Ziesmann, J. C. Garmey, and R. G. Mirmira Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene Transcription in Pancreatic {beta} Cells J. Biol. Chem., June 20, 2003; 278(26): 23617 - 23623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lachner, R. J. O'Sullivan, and T. Jenuwein An epigenetic road map for histone lysine methylation J. Cell Sci., June 1, 2003; 116(11): 2117 - 2124. [Full Text] [PDF]
|
|
|
|
|
|
H. Im, C. Park, Q. Feng, K. D. Johnson, C. M. Kiekhaefer, K. Choi, Y. Zhang, and E. H. Bresnick Dynamic Regulation of Histone H3 Methylated at Lysine 79 within a Tissue-specific Chromatin Domain J. Biol. Chem., May 9, 2003; 278(20): 18346 - 18352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Shogren-Knaak, C. J. Fry, and C. L. Peterson A Native Peptide Ligation Strategy for Deciphering Nucleosomal Histone Modifications J. Biol. Chem., April 25, 2003; 278(18): 15744 - 15748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Li, L. Howe, S. Anderson, J. R. Yates III, and J. L. Workman The Set2 Histone Methyltransferase Functions through the Phosphorylated Carboxyl-terminal Domain of RNA Polymerase II J. Biol. Chem., March 7, 2003; 278(11): 8897 - 8903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. An and R. G. Roeder Direct Association of p300 with Unmodified H3 and H4 N Termini Modulates p300-dependent Acetylation and Transcription of Nucleosomal Templates J. Biol. Chem., January 10, 2003; 278(3): 1504 - 1510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kondo, L. Shen, and J.-P. J. Issa Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer Mol. Cell. Biol., January 1, 2003; 23(1): 206 - 215. [Abstract] [Full Text]
|
|
|
|
|
|
S. Koizume, K. Tachibana, T. Sekiya, S. Hirohashi, and M. Shiraishi Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells Nucleic Acids Res., November 1, 2002; 30(21): 4770 - 4780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Rice, K. Nishioka, K. Sarma, R. Steward, D. Reinberg, and C. D. Allis Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes Genes & Dev., September 1, 2002; 16(17): 2225 - 2230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Bernstein, E. L. Humphrey, R. L. Erlich, R. Schneider, P. Bouman, J. S. Liu, T. Kouzarides, and S. L. Schreiber Methylation of histone H3 Lys 4 in coding regions of active genes PNAS, June 25, 2002; 99(13): 8695 - 8700. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
