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Originally published In Press as doi:10.1074/jbc.M110291200 on January 22, 2002

J. Biol. Chem., Vol. 277, Issue 14, 12270-12274, April 5, 2002
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Syndesmos, a Syndecan-4 Cytoplasmic Domain Interactor, Binds to the Focal Adhesion Adaptor Proteins Paxillin and Hic-5*

Fabienne Denhez, Sarah A. Wilcox-AdelmanDagger , Peter C. Baciu§, Stefania Saoncella, Sohyung Lee, Becki French, Wendy Neveu, and Paul F. Goetinck

From the Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129

Syndecan-4 and integrins are the primary transmembrane receptors of focal adhesions in cells adherent to extracellular matrix molecules. Syndesmos is a cytoplasmic protein that interacts specifically with the cytoplasmic domain of syndecan-4, and it co-localizes with syndecan-4 in focal contacts. In the present study we sought possible interactors with syndesmos. We find that syndesmos interacts with the focal adhesion adaptor protein paxillin. The binding of syndesmos to paxillin is direct, and these interactions are triggered by the activation of protein kinase C. Syndesmos also binds the paxillin homolog, Hic-5. The connection of syndecan-4 with paxillin through syndesmos parallels the connection between paxillin and integrins and may thus reflect the cooperative signaling of these two receptors in the assembly of focal adhesions and actin stress fibers.

* This work was supported in part by NICHD, National Institutes of Health Grant HD-37490 and by the Cutaneous Biology Research Center through a MGH/Shiseido Company agreement (to P. F. G.) and by a Dermatology Foundation Research grant (to F. D.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EBI Data Bank with accession number(s) AF435792.

Dagger Supported by National Institutes of Health Postdoctoral Fellowship F32 HD41235.

§ Present address: Allergan Inc., 2525 Dupont Dr., Irvine, CA 92612.

To whom correspondence should be addressed: Cutaneous Biology Research Center, MGH-East, Bldg. 149, 13th St., Charlestown, MA 02129. Tel.: 617-726-4183; Fax: 617-726-4189; E-mail: paul.goetinck@cbrc2.mgh.harvard.edu.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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