JBC GenomeOne product landing page

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M111371200 on January 17, 2002

J. Biol. Chem., Vol. 277, Issue 15, 13007-13015, April 12, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/15/13007    most recent
M111371200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koipally, J.
Right arrow Articles by Georgopoulos, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koipally, J.
Right arrow Articles by Georgopoulos, K.

Unconventional Potentiation of Gene Expression by Ikaros*

Joseph Koipally, Elizabeth J. Heller, John R. SeavittDagger , and Katia Georgopoulos§

From the Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129

Ikaros is essential for the normal development and regulated proliferation of lymphoid cells. In lymphocytes, Ikaros exists as an integral component of chromatin-remodeling complexes, including the Mi-2beta /nucleosome remodeling and deacetylation complex (NuRD) complex. It is expected that Ikaros, together with these associated activities effects repression, but here we show that they may also potentiate gene expression in cycling cells. Ikaros cannot activate transcription by itself; instead, it enhances the activity of both weak and strong activators. For this role in potentiation, Ikaros requires its DNA binding and dimerization domains. The DNA binding and dimerization properties of Ikaros are also responsible for its targeting to pericentromeric heterochromatin (PC-HC). Significantly, Ikaros mutants with altered specificity for DNA binding that are unable to localize to PC-HC are incapable of stimulating transcription from reporters bearing their cognate sites. Thus, potentiation of gene expression by Ikaros correlates strongly with its ability to localize to PC-HC in combination with the chromatin remodeler Mi-2beta .

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger Supported by National Institutes of Health Grant RO1-AI380342-08.

§ Supported by National Institutes of Health Grant F32-GM20724. To whom correspondence should be addressed: Cutaneous Biology Research Center, Massachusetts General Hospital East, Bldg. 149, 13th St., Charlestown, MA 02129. Tel.: 617-726-4445; Fax: 617-726-4453; E-mail: katia.georgopoulos@cbrc2.mgh.harvard.edu.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.


This article has been cited by other articles:


Home page
 Cancer Res.Home page
S. Loeper, S. L. Asa, and S. Ezzat
Ikaros Modulates Cholesterol Uptake: A Link between Tumor Suppression and Differentiation
Cancer Res., May 15, 2008; 68(10): 3715 - 3723.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. L. Kathrein, S. Chari, and S. Winandy
Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell Line: IMPLICATIONS FOR CD4 REGULATION
J. Biol. Chem., April 18, 2008; 283(16): 10476 - 10484.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Sridharan and S. T. Smale
Predominant Interaction of Both Ikaros and Helios with the NuRD Complex in Immature Thymocytes
J. Biol. Chem., October 12, 2007; 282(41): 30227 - 30238.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Saether, T. Berge, M. Ledsaak, V. Matre, A. H. Alm-Kristiansen, O. Dahle, F. Aubry, and O. S. Gabrielsen
The Chromatin Remodeling Factor Mi-2{alpha} Acts as a Novel Co-activator for Human c-Myb
J. Biol. Chem., May 11, 2007; 282(19): 13994 - 14005.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
K. Yamashita, A. Sato, M. Asashima, P.-C. Wang, and R. Nishinakamura
Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains.
Genes Cells, February 1, 2007; 12(2): 171 - 182.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Ronni, K. J. Payne, S. Ho, M. N. Bradley, G. Dorsam, and S. Dovat
Human Ikaros Function in Activated T Cells Is Regulated by Coordinated Expression of Its Largest Isoforms
J. Biol. Chem., January 26, 2007; 282(4): 2538 - 2547.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
V. Carriere, L. Roussel, N. Ortega, D.-A. Lacorre, L. Americh, L. Aguilar, G. Bouche, and J.-P. Girard
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
PNAS, January 2, 2007; 104(1): 282 - 287.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. B. Cismasiu, S. Ghanta, J. Duque, D. I. Albu, H.-M. Chen, R. Kasturi, and D. Avram
BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes
Blood, October 15, 2006; 108(8): 2695 - 2702.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Srinivasan, G. M. Mager, R. M. Ward, J. Mayer, and J. Svaren
NAB2 Represses Transcription by Interacting with the CHD4 Subunit of the Nucleosome Remodeling and Deacetylase (NuRD) Complex
J. Biol. Chem., June 2, 2006; 281(22): 15129 - 15137.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. J. Westman, J. Perdomo, M. Sunde, M. Crossley, and J. P. Mackay
The C-terminal Domain of Eos Forms a High Order Complex in Solution
J. Biol. Chem., October 24, 2003; 278(43): 42419 - 42426.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Ezzat, S. Yu, and S. L. Asa
Ikaros Isoforms in Human Pituitary Tumors: Distinct Localization, Histone Acetylation, and Activation of the 5' Fibroblast Growth Factor Receptor-4 Promoter
Am. J. Pathol., September 1, 2003; 163(3): 1177 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. J. Payne, G. Huang, E. Sahakian, J. Y. Zhu, N. S. Barteneva, L. W. Barsky, M. A. Payne, and G. M. Crooks
Ikaros Isoform X Is Selectively Expressed in Myeloid Differentiation
J. Immunol., March 15, 2003; 170(6): 3091 - 3098.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Dumortier, P. Kirstetter, P. Kastner, and S. Chan
Ikaros regulates neutrophil differentiation
Blood, March 15, 2003; 101(6): 2219 - 2226.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Schaufele, X. Wang, X. Liu, and R. N. Day
Conformation of CCAAT/Enhancer-binding Protein alpha Dimers Varies with Intranuclear Location in Living Cells
J. Biol. Chem., March 14, 2003; 278(12): 10578 - 10587.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. K. Ray, J. Nishitani, M. W. Petry, M. Y. Fessing, and A. B. Leiter
Novel Transcriptional Potentiation of BETA2/NeuroD on the Secretin Gene Promoter by the DNA-Binding Protein Finb/RREB-1
Mol. Cell. Biol., January 1, 2003; 23(1): 259 - 271.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. Koipally and K. Georgopoulos
Ikaros-CtIP Interactions Do Not Require C-terminal Binding Protein and Participate in a Deacetylase-independent Mode of Repression
J. Biol. Chem., June 21, 2002; 277(26): 23143 - 23149.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.