| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 277, Issue 16, 13831-13839, April 19, 2002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Department of Biochemistry and Molecular Biology, State
University of New York, Upstate Medical University, Syracuse, New York
13210
Vacuolar proton-translocating ATPases are
composed of a peripheral complex, V1, attached to an
integral membrane complex, Vo. Association of the two
complexes is essential for ATP-driven proton transport and is regulated
post-translationally in response to glucose concentration. A new
complex, RAVE, was recently isolated and implicated in
glucose-dependent reassembly of V-ATPase complexes that had
disassembled in response to glucose deprivation (Seol, J. H.,
Shevchenko, A., and Deshaies, R. J. (2001) Nat. Cell
Biol. 3, 384-391). Here, we provide evidence supporting a role
for RAVE in reassembly of the V-ATPase but also demonstrate an
essential role in V-ATPase assembly under other conditions. The RAVE
complex associates reversibly with V1 complexes released
from the membrane by glucose deprivation but binds constitutively to
cytosolic V1 sectors in a mutant lacking Vo
sectors. V-ATPase complexes from cells lacking RAVE subunits show
serious structural and functional defects even in glucose-grown cells
or in combination with a mutation that blocks disassembly of the
V-ATPase. RAVE·V1 interactions are specifically
disrupted in cells lacking V1 subunits E or G, suggesting a
direct involvement for these subunits in interaction of the two
complexes. Skp1p, a RAVE subunit involved in many different signal
transduction pathways, binds stably to other RAVE subunits under
conditions that alter RAVE·V1 binding; thus, Skp1p
recruitment to the RAVE complex does not appear to provide a signal for
V-ATPase assembly.
The RAVE Complex Is Essential for Stable Assembly of the Yeast
V-ATPase*
*
This work was supported by National Institutes of Health
Grant GM50322 (to P. M. K.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Dept. of Biochemistry
and Molecular Biology, State University of New York, Upstate Medical
University, 750 East Adams St., Syracuse, NY 13210. Tel.: 315-464-8742;
Fax: 315-464-8736; E-mail: kanepm@upstate.edu.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Qi and M. Forgac Function and Subunit Interactions of the N-terminal Domain of Subunit a (Vph1p) of the Yeast V-ATPase J. Biol. Chem., July 11, 2008; 283(28): 19274 - 19282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dawson, W. M. Toone, N. Jones, and C. R. M. Wilkinson Loss of Regulators of Vacuolar ATPase Function and Ceramide Synthesis Results in Multidrug Sensitivity in Schizosaccharomyces pombe Eukaryot. Cell, June 1, 2008; 7(6): 926 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rein, M. Voss, W. Blenau, B. Walz, and O. Baumann Hormone-induced assembly and activation of V-ATPase in blowfly salivary glands is mediated by protein kinase A Am J Physiol Cell Physiol, January 1, 2008; 294(1): C56 - C65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Smardon and P. M. Kane RAVE Is Essential for the Efficient Assembly of the C Subunit with the Vacuolar H+-ATPase J. Biol. Chem., September 7, 2007; 282(36): 26185 - 26194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Qi and M. Forgac Cellular Environment Is Important in Controlling V-ATPase Dissociation and Its Dependence on Activity J. Biol. Chem., August 24, 2007; 282(34): 24743 - 24751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lu, D. Ammar, H. Ives, F. Albrecht, and S. L. Gluck Physical Interaction between Aldolase and Vacuolar H+-ATPase Is Essential for the Assembly and Activity of the Proton Pump J. Biol. Chem., August 24, 2007; 282(34): 24495 - 24503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Imamura, S. Funamoto, M. Yoshida, and K. Yokoyama Reconstitution in Vitro of V1 Complex of Thermus thermophilus V-ATPase Revealed That ATP Binding to the A Subunit Is Crucial for V1 Formation J. Biol. Chem., December 15, 2006; 281(50): 38582 - 38591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Brace, L. P. Parkinson, and R. S. Fuller Skp1p Regulates Soi3p/Rav1p Association with Endosomal Membranes but Is Not Required for Vacuolar ATPase Assembly Eukaryot. Cell, December 1, 2006; 5(12): 2104 - 2113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Beyenbach and H. Wieczorek The V-type H+ ATPase: molecular structure and function, physiological roles and regulation J. Exp. Biol., February 15, 2006; 209(4): 577 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jeyaraj, D. Dakhlallah, S. R. Hill, and B. S. Lee HuR Stabilizes Vacuolar H+-translocating ATPase mRNA during Cellular Energy Depletion J. Biol. Chem., November 11, 2005; 280(45): 37957 - 37964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Liu, M. Tarsio, C. M. H. Charsky, and P. M. Kane Structural and Functional Separation of the N- and C-terminal Domains of the Yeast V-ATPase Subunit H J. Biol. Chem., November 4, 2005; 280(44): 36978 - 36985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Owegi, A. L. Carenbauer, N. M. Wick, J. F. Brown, K. L. Terhune, S. A. Bilbo, R. S. Weaver, R. Shircliff, N. Newcomb, and K. J. Parra-Belky Mutational Analysis of the Stator Subunit E of the Yeast V-ATPase J. Biol. Chem., May 6, 2005; 280(18): 18393 - 18402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Waterford, T. R. Kolodecik, E. C. Thrower, and F. S. Gorelick Vacuolar ATPase Regulates Zymogen Activation in Pancreatic Acini J. Biol. Chem., February 18, 2005; 280(7): 5430 - 5434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Y. Sautin, M. Lu, A. Gaugler, L. Zhang, and S. L. Gluck Phosphatidylinositol 3-Kinase-Mediated Effects of Glucose on Vacuolar H+-ATPase Assembly, Translocation, and Acidification of Intracellular Compartments in Renal Epithelial Cells Mol. Cell. Biol., January 15, 2005; 25(2): 575 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Wagner, K. E. Finberg, S. Breton, V. Marshansky, D. Brown, and J. P. Geibel Renal Vacuolar H+-ATPase Physiol Rev, October 1, 2004; 84(4): 1263 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sipos, J. H. Brickner, E.J. Brace, L. Chen, A. Rambourg, F. Kepes, and R. S. Fuller Soi3p/Rav1p Functions at the Early Endosome to Regulate Endocytic Trafficking to the Vacuole and Localization of Trans-Golgi Network Transmembrane Proteins Mol. Biol. Cell, July 1, 2004; 15(7): 3196 - 3209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sambade and P. M. Kane The Yeast Vacuolar Proton-translocating ATPase Contains a Subunit Homologous to the Manduca sexta and Bovine e Subunits That Is Essential for Function J. Biol. Chem., April 23, 2004; 279(17): 17361 - 17365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lu, Y. Y. Sautin, L. S. Holliday, and S. L. Gluck The Glycolytic Enzyme Aldolase Mediates Assembly, Expression, and Activity of Vacuolar H+-ATPase J. Biol. Chem., March 5, 2004; 279(10): 8732 - 8739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Chung, R. L. Lester, and R. C. Dickson Sphingolipid Requirement for Generation of a Functional V1 Component of the Vacuolar ATPase J. Biol. Chem., August 1, 2003; 278(31): 28872 - 28881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Vitavska, H. Wieczorek, and H. Merzendorfer A Novel Role for Subunit C in Mediating Binding of the H+-V-ATPase to the Actin Cytoskeleton J. Biol. Chem., May 9, 2003; 278(20): 18499 - 18505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Shao, T. Nishi, S. Kawasaki-Nishi, and M. Forgac Mutational Analysis of the Non-homologous Region of Subunit A of the Yeast V-ATPase J. Biol. Chem., April 4, 2003; 278(15): 12985 - 12991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hermand, S. Bamps, L. Tafforeau, J. Vandenhaute, and T. P. Makela Skp1 and the F-box Protein Pof6 Are Essential for Cell Separation in Fission Yeast J. Biol. Chem., March 7, 2003; 278(11): 9671 - 9677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Trombetta, M. Ebersold, W. Garrett, M. Pypaert, and I. Mellman Activation of Lysosomal Function During Dendritic Cell Maturation Science, February 28, 2003; 299(5611): 1400 - 1403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Saliba, R. J. W. Allen, S. Zissis, P. G. Bray, S. A. Ward, and K. Kirk Acidification of the Malaria Parasite's Digestive Vacuole by a H+-ATPase and a H+-pyrophosphatase J. Biol. Chem., February 14, 2003; 278(8): 5605 - 5612. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
