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J. Biol. Chem., Vol. 277, Issue 16, 14211-14215, April 19, 2002
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From the Department of Physiological Chemistry, Graduate School of
Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto
606-8501, Japan and the Department of Physiological Chemistry, Graduate
School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku,
Kyoto 606-8501, Japan
Histamine synthesis in male reproductive tissues
remains largely unknown. The interaction between stem cell factor and
its receptor, c-Kit, has been found to be essential for the
maturation of male germ cells and peripheral mast cells. Based on this
analogy, we investigated the expression of histidine decarboxylase
(HDC), the rate-limiting enzyme of histamine synthesis, in mouse male germ cells. Immunohistochemical analyses revealed that HDC is localized
in the acrosomes of spermatids and spermatozoa. In the testis,
epididymis, and spermatozoa, a significant amount of histamine and HDC
activity were detected. W/WV mice, known to lack most
of their germ cells in the seminiferous tubules, were found to lack HDC
protein expression as well as HDC activity in the testis. An in
vitro acrosome reaction induced by a calcium ionophore, A23187,
caused the release of histamine from epididymal spermatozoa. Our
observations indicate that histamine is produced in and released from
the acrosomes.
Expression of L-Histidine Decarboxylase in Mouse Male
Germ Cells*
*
This work was supported by grants-in-aid for Scientific
Research from the Ministry of Education, Science, Sports, and Culture, Japan.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.: 81-75-753-4527;
Fax: 81-75-753-4557; E-mail: aichikaw@pharm.kyoto-u.ac.jp.
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