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Originally published In Press as doi:10.1074/jbc.C200099200 on March 13, 2002

J. Biol. Chem., Vol. 277, Issue 17, 14359-14362, April 26, 2002
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ACCELERATED PUBLICATION
Reciprocal Recruitment of DRIP/Mediator and p160 Coactivator Complexes in Vivo by Estrogen Receptor*

Darya Burakov, Linda A. Crofts, Chao-Pei Betty Chang, and Leonard P. FreedmanDagger

From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Joan and Sanford I. Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021

Two functionally distinct classes of coactivators are recruited by liganded estrogen receptor, the DRIP/Mediator complex and p160 proteins, although the relative dynamics of recruitment is unclear. Previously, we have shown a direct, estradiol-dependent interaction between the DRIP205 subunit of the DRIP complex and the estrogen receptor (ER) AF2 domain. Here we demonstrate the in vivo recruitment of other endogenous DRIP subunits to ER in response to estradiol treatment in MCF-7 cells. To explore the relationship between DRIP and p160 coactivators, we examined the kinetics of coactivator recruitment to the ER target promoter, pS2, by chromatin immunoprecipitation. We observed a cyclic association and dissociation of coactivators with the promoter, with recruitment of p160s and DRIPs occurring in opposite phases, suggesting an exchange between these coactivator complexes at the target promoter.

* This work was supported by National Institutes of Health Grant DK45460 and Department of Defense Grant BC000790.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Dept. of Bone Biology, Merck Research Laboratories, WP26A-1000, West Point, PA 19486. Tel.: 215-652-6495; Fax: 215-993-1340; E-mail: leonard_freedman@merck.com.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.


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