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J. Biol. Chem., Vol. 277, Issue 18, 15221-15224, May 3, 2002
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From the Using sequence homology searches, yeast
two-hybrid assays and glutathione S-transferase
(GST)-pull-down approaches we have identified a series of glutamate
receptor subunits that interact differentially with the PDZ proteins
GRIP, PICK1, and syntenin. GST-pull-down experiments identified more
interactions than detected by yeast two-hybrid assays. We report
several receptor-protein interactions, strong ones include: (i) GRIP
and syntenin with mGluR7a, mGluR4a, and mGluR6; (ii) PICK1 and GRIP
with mGluR3; and (iii) syntenin with all forms of GluR1-4 and mGluR7b.
We further characterized the novel mGluR7a-GRIP interaction found both
in yeast two-hybrid and GST-pull-down assays and observed that mGluR7a localization overlapped with GRIP with in hippocampal neurons. The wide
range of targets for PICK1, GRIP, and syntenin suggests they may
represent a molecular mechanism that can concentrate and/or regulate a
number of different receptors at a common site on a synapse. These data
also suggest that the structural determinants involved in PDZ
interactions are more complex than originally envisaged.
ACCELERATED PUBLICATION
The PDZ Proteins PICK1, GRIP, and Syntenin Bind Multiple
Glutamate Receptor Subtypes
ANALYSIS OF PDZ BINDING MOTIFS*
,,,,, and§¶
Department of Anatomy, Medical Research
Council Centre of Synaptic Plasticity, Medical School, University of
Bristol, Bristol BS8 1TD, United Kingdom and the
§ Department of Biological Sciences, Kyoto University,
Faculty of Medicine, Kyoto 606-8501, Japan
*
This work was supported in part by research grants from the
Medical Research Council (UK), the Wellcome Trust (UK), the France Alzheimer and AFRT (France), and the Ministry of Education, Science and
Culture of Japan (Japan).The costs of publication of this article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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