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Originally published In Press as doi:10.1074/jbc.M201140200 on March 4, 2002

J. Biol. Chem., Vol. 277, Issue 19, 16831-16836, May 10, 2002
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A Novel Type I Cytokine Receptor Is Expressed on Monocytes, Signals Proliferation, and Activates STAT-3 and STAT-5*

Nico GhilardiDagger , Ji LiDagger , Jo-Anne Hongo§, Sothy Yi, Austin Gurney, and Frederic J. de SauvageDagger ||

From the Departments of Dagger  Molecular Oncology, § Antibody Technology, and  Molecular Biology, Genentech, Inc., South San Francisco, California 94080

Here we report the cloning of a novel type I cytokine receptor, gp130-like monocyte receptor (GLM-R), with homology to the interleukin-6 receptor signal transducing chain, gp130, and granulocyte colony-stimulating factor receptor. Human and murine GLM-R cDNAs encode open reading frames of 732 and 716 amino acids, respectively, and the corresponding genes are located in close proximity to gp130 genes on human chromosome 5 and mouse chromosome 13. GLM-R is specifically expressed on CD14-positive cells and is up-regulated more than 50-fold upon activation of those cells. To address the question of whether GLM-R is a signaling receptor, we constructed a chimeric molecule, consisting of the extracellular domain of human growth hormone (hGH) receptor, and the intracellular domain of GLM-R. When transfected into factor-dependent 32D cells, this chimeric molecule could signal for proliferation and activate signal transducer and activator of transcription (STAT)-3 and STAT-5 upon stimulation with hGH. Thus, GLM-R is a novel signaling receptor chain potentially involved in the development and function of monocytes and macrophages.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

|| To whom correspondence should be addressed: Genentech, Inc., 1-DNA Way, Mailstop no. 40, South San Francisco, CA 94080-4990. E-mail: sauvage@gene.com.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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