JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M201388200 on March 7, 2002

J. Biol. Chem., Vol. 277, Issue 21, 18266-18271, May 24, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/21/18266    most recent
M201388200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paulsson, K. M.
Right arrow Articles by Wang, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paulsson, K. M.
Right arrow Articles by Wang, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Association of Tapasin and COPI Provides a Mechanism for the Retrograde Transport of Major Histocompatibility Complex (MHC) Class I Molecules from the Golgi Complex to the Endoplasmic Reticulum*

Kajsa M. PaulssonDagger §, Monique J. Kleijmeer, Janice Griffith, Marc Jevon§, Shangwu ChenDagger §, Per O. AndersonDagger §, Hans-Olov SjögrenDagger , Suling LiDagger ||**, and Ping Wang§Dagger Dagger

From the Dagger  Institution of Tumor Immunology, Lund University, Solvegatan 21, s-223 62 Lund, Sweden, the  Department of Cell Biology, University Medical Centre, Institute of Biomembranes, 3584 CX Utrecht, The Netherlands, the || Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom, and the § Immunology Group, Department of Gastroenterology, Barts and The London School of Medicine and Dentistry, 59 Bartholomew's Close, London EC1A 7ED, United Kingdom

Tapasin is a subunit of the transporter associated with antigen processing (TAP). It associates with the major histocompatibility complex (MHC) class I. We show that tapasin interacts with beta - and gamma -subunits of COPI coatomer. COPI retrieves membrane proteins from the Golgi network back to the endoplasmic reticulum (ER). The COPI subunit-associated tapasin also interacts with MHC class I molecules suggesting that tapasin acts as the cargo receptor for packing MHC class I molecules as cargo proteins into COPI-coated vesicles. In tapasin mutant cells, neither TAP nor MHC class I are detected in association with the COPI coatomer. Interestingly, tapasin-associated MHC class I molecules are antigenic peptide-receptive and detected in both the ER and the Golgi. Our data suggest that tapasin is required for the COPI vesicle-mediated retrograde transport of immature MHC class I molecules from the Golgi network to the ER.

* This study was supported by Crafoordska Stiftelsen Grant 990589, the Swedish Cancer Society Grants 3975-B99-03XAB and 4504-B01-01RAA, the Medical Faculty, Lund University, the Swedish Foundation for Strategic Research (Infection and Vaccinology, 36/98 and from Inflammation Research Program/99), STINT The Swedish Foundation for International Cooperation in Research and Higher Education Grant 2001-6099, the Emma Ekstrands, Hildur Teggers, and Jan Teggers Fundation, and Grant 805-48-014 from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

** To whom correspondence may be addressed. Tel.: 44-20-76018469; Fax: 44-20-76005901; E-mail: su-ling.li@wblab.lu.se.

Dagger Dagger To whom correspondence may be addressed. Tel.: 44-20-76018469; Fax: 44-20-76005901: E-mail: p.wang@qmul.ac.uk.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Virol.Home page
G. Roder, L. Geironson, I. Bressendorff, and K. Paulsson
Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
J. Virol., September 1, 2008; 82(17): 8246 - 8252.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Tuli, M. Sharma, M. M. McIlhaney, J. E. Talmadge, N. Naslavsky, S. Caplan, and J. C. Solheim
Amyloid Precursor-Like Protein 2 Increases the Endocytosis, Instability, and Turnover of the H2-Kd MHC Class I Molecule
J. Immunol., August 1, 2008; 181(3): 1978 - 1987.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Rennolds, C. Tower, L. Musgrove, L. Fan, K. Maloney, J. P. Clancy, K. L. Kirk, E. Sztul, and E. Cormet-Boyaka
Cystic Fibrosis Transmembrane Conductance Regulator Trafficking Is Mediated by the COPI Coat in Epithelial Cells
J. Biol. Chem., January 11, 2008; 283(2): 833 - 839.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. W. Everett and M. Edidin
Tapasin Increases Efficiency of MHC I Assembly in the Endoplasmic Reticulum but Does Not Affect MHC I Stability at the Cell Surface
J. Immunol., December 1, 2007; 179(11): 7646 - 7652.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Garstka, B. Borchert, M. Al-Balushi, P. Praveen, N. Kuhl, I. Majoul, R. Duden, and S. Springer
Peptide-receptive Major Histocompatibility Complex Class I Molecules Cycle between Endoplasmic Reticulum and cis-Golgi in Wild-type Lymphocytes
J. Biol. Chem., October 19, 2007; 282(42): 30680 - 30690.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Papadopoulos and F. Momburg
Multiple Residues in the Transmembrane Helix and Connecting Peptide of Mouse Tapasin Stabilize the Transporter Associated with the Antigen-processing TAP2 Subunit
J. Biol. Chem., March 30, 2007; 282(13): 9401 - 9410.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. J. Ladasky, S. Boyle, M. Seth, H. Li, T. Pentcheva, F. Abe, S. J. Steinberg, and M. Edidin
Bap31 Enhances the Endoplasmic Reticulum Export and Quality Control of Human Class I MHC Molecules
J. Immunol., November 1, 2006; 177(9): 6172 - 6181.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. M. Paulsson, M. Jevon, J. W. Wang, S. Li, and P. Wang
The double lysine motif of tapasin is a retrieval signal for retention of unstable MHC class I molecules in the endoplasmic reticulum.
J. Immunol., June 15, 2006; 176(12): 7482 - 7488.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. H. Boyle, A. K. Gillingham, S. Munro, and J. Trowsdale
Selective Export of HLA-F by Its Cytoplasmic Tail.
J. Immunol., June 1, 2006; 176(11): 6464 - 6472.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Li, B. A. Sullivan, C. J. Aldrich, M. J. Soloski, J. Forman, A. G. Grandea III, P. E. Jensen, and L. Van Kaer
Differential Requirement for Tapasin in the Presentation of Leader- and Insulin-Derived Peptide Antigens to Qa-1b-Restricted CTLs
J. Immunol., September 15, 2004; 173(6): 3707 - 3715.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M.-E. Paquet, M. Cohen-Doyle, G. C. Shore, and D. B. Williams
Bap29/31 Influences the Intracellular Traffic of MHC Class I Molecules
J. Immunol., June 15, 2004; 172(12): 7548 - 7555.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. M. Tran, N. Satumtira, M. L. Dorris, E. May, A. Wang, E. Furuta, and J. D. Taurog
HLA-B27 in Transgenic Rats Forms Disulfide-Linked Heavy Chain Oligomers and Multimers That Bind to the Chaperone BiP
J. Immunol., April 15, 2004; 172(8): 5110 - 5119.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K. M. PAULSSON and P. WANG
Quality control of MHC class I maturation
FASEB J, January 1, 2004; 18(1): 31 - 38.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.