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J. Biol. Chem., Vol. 277, Issue 21, 18334-18339, May 24, 2002
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From the A secretory defect leads to transcriptional
repression of both ribosomal protein and rRNA genes in yeast. To
elucidate the mechanism of the signaling, we previously isolated
rrs mutants that were unable to respond to a secretory
defect, and we cloned RRS1 encoding a nuclear protein that
was required for ribosome biogenesis (Tsuno, A., Miyoshi, K., Tsujii,
R., Miyakawa, T., and Mizuta, K. (2000) Mol. Cell. Biol.
20, 2066-2074). We identified duplicated genes encoding ribosomal
protein L11, RPL11B as a wild-type allele complementing the
rrs2 mutation, and RPL11A in two-hybrid screening using RRS1 as bait. Rpl11p was copurified with
Rrs1p in immunoprecipitation analysis. Ultracentrifugation analysis revealed that Rrs1p associated fairly tightly with 60 S preribosomal subunits. These results suggest that signaling in response to a
secretory defect requires the normal assembly of 60 S ribosomal subunits including Rrs1p and Rpl11p.
Normal Assembly of 60 S Ribosomal Subunits Is Required for
the Signaling in Response to a Secretory Defect in
Saccharomyces cerevisiae*
§,
,, and§**
Department of Biological Sciences, Graduate
School of Biosphere Sciences and § Department of Molecular
Biotechnology, Graduate School of Advanced Sciences of Matter,
Hiroshima University, Kagamiyama, Higashi-Hiroshima 739-8528, Japan, ¶ Department of Physics, Osaka Medical College,
Takatsuki, Osaka 569-0084, Japan, and the Department of
Biological Sciences, Graduate School of Science, The University of
Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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