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Originally published In Press as doi:10.1074/jbc.M201934200 on March 13, 2002

J. Biol. Chem., Vol. 277, Issue 22, 19538-19545, May 31, 2002
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A Ubiquitously Expressed Human Hexacoordinate Hemoglobin*

James T. Trent III and Mark S. HargroveDagger

From the Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011

We have identified a new human hemoglobin that we call histoglobin because it is expressed in a wide array of tissues. Histoglobin shares less than 30% identity with the other human hemoglobins, and the gene contains an intron in an unprecedented location. Spectroscopic and kinetic experiments with recombinant human histoglobin indicate that it is a hexacoordinate hemoglobin with significantly different ligand binding characteristics than the other human hexacoordinate hemoglobin, neuroglobin. In contrast to the very high oxygen affinities displayed by most hexacoordinate hemoglobins, the biophysical characteristics of histoglobin indicate that it could facilitate oxygen transport. The discovery of histoglobin demonstrates that humans, like plants, differentially express multiple hexacoordinate hemoglobins.

* This work was funded in part by United States Department of Agriculture Grant 99-35306-7833.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Dept. of Biochemistry, Biophysics, and Molecular Biology, 4114 Molecular Biology Bldg., Iowa State University, Ames, IA 50011. Tel.: 515-294-2616; Fax: 515-294-0453; E-mail: msh@iastate.edu.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.


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