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J. Biol. Chem., Vol. 277, Issue 22, 19609-19617, May 31, 2002
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From the Department of Biology, City College of the City University
of New York, New York, New York 10031
The yeast open reading frame YOL002c
encodes a putative membrane protein. This protein is evolutionarily
conserved across species, including humans, although the function of
each of these proteins remains unknown. YOL002c is highly
expressed in yeast cells that are grown in the presence of saturated
fatty acids such as myristate. Furthermore, cells in which the
YOL002c gene is disrupted grow poorly on this carbon
source. These mutant cells are also resistant to the polyene
antibiotic, nystatin. Gene chip analysis on
yol002c
Multiple Regulatory Roles of a Novel Saccharomyces
cerevisiae Protein, Encoded by YOL002c, in Lipid and
Phosphate Metabolism*
,, and
cells revealed that a variety of genes encoding proteins involved in fatty acid metabolism and in the phosphate signaling pathway are induced in this mutant strain. In addition, our
studies demonstrated that in the disruption strain acid phosphatase activity is expressed constitutively, and the cells accumulate polyphosphate to much higher levels than wild-type cells. A homologous human protein is able to partially rescue these defects in phosphate metabolism. We propose that YOL002c encodes a
Saccharomyces cerevisiae protein that plays a key role in
metabolic pathways that regulate lipid and phosphate metabolism.
*
This work was supported by National Institutes of Health
Grants RO1DK54976 and RCMI Grant G12 RR03060.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Both authors contributed equally to this work.
§
To whom correspondence should be addressed. Tel.: 212-794-5417;
Fax: 212-794-5378; E-mail: gmsbh@cunyvm.cuny.edu.
Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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