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J. Biol. Chem., Vol. 277, Issue 22, 19946-19951, May 31, 2002
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From the Angiogenesis Research Center and Section of Cardiology,
Department of Medicine, Dartmouth Medical School, Lebanon, New
Hampshire 03756
Syndecan-4 is a heparan sulfate-carrying core
protein that has been directly implicated in fibroblast growth factor 2 (FGF2) signaling. Recent studies have suggested that many signaling
proteins localize to the raft compartment of the plasma cell membrane. To establish whether syndecan-4 is present in the raft compartment, we
have studied the distribution of the core protein and an Fc receptor
(FcR)-syndecan-4 chimera prior to and following clustering with FGF2 or
antibodies. Whereas unclustered syndecan-4 was present predominantly in
the non-raft membrane compartment, clustering induced extensive
syndecan-4 redistribution to the rafts as demonstrated by the sucrose
gradient centrifugation and life confocal microscopy. Although
syndecan-4 and caveolin-1 moved in tandem, syndecan-4 was not present
in caveolae, a major subset of raft compartments. We conclude that
syndecan-4 clustering induces its redistribution to the non-caveolae
raft compartment. This process may play an important role in
syndecan-4-mediation of FGF2 signaling.
Clustering Induces Redistribution of Syndecan-4 Core Protein into
Raft Membrane Domains*
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Section of Cardiology,
Dartmouth-Hitchcock Medical Center, One Medical Center Dr., Lebanon, NH
03756. Tel.: 603-650-3540; Fax: 603-650-6164; E-mail:
michael.simons@dartmouth.edu.
Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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