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J. Biol. Chem., Vol. 277, Issue 23, 20686-20693, June 7, 2002
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From the Lectins on antigen presenting cells are
potentially involved in the antigen uptake and the cellular recognition
and trafficking. Serial analysis of gene expression in monocyte-derived
dendritic cells (DCs), monocytes, and macrophages revealed that 7 of
the 19 C-type lectin mRNA were present in immature DCs. Two of
these, the macrophage mannose receptor and the macrophage lectin
specific for galactose/N-acetylgalactosamine (MGL), were
found only in immature DCs, as confirmed by reverse transcriptase-PCR
and flow cytometric analysis. By subcloning and sequencing the
amplified mRNA, we obtained nucleotide sequences encoding seven
different human MGL (hMGL) subtypes, which were apparently derived from alternatively spliced mRNA. In addition, the hMGL gene locus on human chromosome 17p13 contains one gene. A single nucleotide polymorphism was identified at a position in exon 3 that corresponds to
the cytoplasmic region proximal to the transmembrane domain. Of all the splicing variants, the hMGL variant 6C was expressed at the
highest levels on immature DCs from all donors tested. Immature DCs
could incorporate
The Macrophage C-type Lectin Specific for
Galactose/N-Acetylgalactosamine Is an Endocytic Receptor
Expressed on Monocyte-derived Immature Dendritic Cells*
,,,,,,,,,,¶
Graduate School of Pharmaceutical Sciences
and the § Department of Molecular Preventive Medicine,
School of Medicine, The University of Tokyo, Bunkyo-ku,
Tokyo 113-0033, Japan
-GalNAc-modified soluble acrylamide polymers, and
this was significantly inhibited by pretreatment of the cells with an
anti-hMGL monoclonal antibody that blocks the lectin-carbohydrate
interaction. We propose that hMGL is a marker of imDCs and that it
functions as an endocytic receptor for glycosylated antigens.
*
This work was supported by Grants-in-aid
07407063, 07557154, 09254101,11557180, 11672162, and 12307054 from the
Ministry of Education, Science, Sports and Culture of Japan, from the
Research Association for Biotechnology, Special Coordination Funds for Promoting Science and Technology of the Ministry of Education, Culture,
Sports, Science and Technology, and from the Program for Promotion of
Basic Research Activities for Innovative Biosciences.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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