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J. Biol. Chem., Vol. 277, Issue 25, 22140-22146, June 21, 2002
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,,,¶
From the The heat shock factor (HSF) is a pivotal
transcriptional factor that regulates the expression of genes encoding
heat shock proteins (HSPs) via heat shock elements (HSEs).
nGAAnnTTCnnGAAn functions as the minimum consensus HSE (cHSE)
in vivo. Here we show that the expression of
Saccharomyces cerevisiae MDJ1 encoding a
mitochondrial DnaJ homolog is regulated by HSF via a novel
non-consensus HSE (ncHSEMDJ1), which consists of three
separated pentameric nGAAn motifs, nTTCn-(11 bp)-nGAAn-(5 bp)-nGAAn.
This is the first evidence to show that the immediate contact of nGAAn
motifs is dispensable for regulation by HSF in vivo.
ncHSEMDJ1 confers different heat shock responses
versus cHSE and, unlike cHSE, definitively requires a
carboxyl-terminal activation domain of HSF in the expression. ncHSEMDJ1-like elements are found in promoter regions of
some other DnaJ-related genes. The highly conserved HSF/HSE
system suggests that similar ncHSEs may be used for the expression of HSP genes in other eukaryotes including humans.
Department of Biology and Geoscience and the
§ Department of Chemistry, Faculty of Science, Shizuoka
University, Shizuoka 422-8529, Japan
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