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Originally published In Press as doi:10.1074/jbc.M201267200 on April 8, 2002

J. Biol. Chem., Vol. 277, Issue 25, 22140-22146, June 21, 2002
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A Novel Non-conventional Heat Shock Element Regulates Expression of MDJ1 Encoding a DnaJ Homolog in Saccharomyces cerevisiae*

Tomohusa TachibanaDagger , Shiho AstumiDagger , Ryo ShiodaDagger , Masaru Ueno§, Masahiro Uritani§, and Takashi UshimaruDagger

From the Dagger  Department of Biology and Geoscience and the § Department of Chemistry, Faculty of Science, Shizuoka University, Shizuoka 422-8529, Japan

The heat shock factor (HSF) is a pivotal transcriptional factor that regulates the expression of genes encoding heat shock proteins (HSPs) via heat shock elements (HSEs). nGAAnnTTCnnGAAn functions as the minimum consensus HSE (cHSE) in vivo. Here we show that the expression of Saccharomyces cerevisiae MDJ1 encoding a mitochondrial DnaJ homolog is regulated by HSF via a novel non-consensus HSE (ncHSEMDJ1), which consists of three separated pentameric nGAAn motifs, nTTCn-(11 bp)-nGAAn-(5 bp)-nGAAn. This is the first evidence to show that the immediate contact of nGAAn motifs is dispensable for regulation by HSF in vivo. ncHSEMDJ1 confers different heat shock responses versus cHSE and, unlike cHSE, definitively requires a carboxyl-terminal activation domain of HSF in the expression. ncHSEMDJ1-like elements are found in promoter regions of some other DnaJ-related genes. The highly conserved HSF/HSE system suggests that similar ncHSEs may be used for the expression of HSP genes in other eukaryotes including humans.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed. Fax: 81-54-238-0986; E-mail: sbtushi@ipc.shizuoka.ac.jp.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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