JBC Advanced Glycation Endproducts

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M203527200 on May 13, 2002

J. Biol. Chem., Vol. 277, Issue 29, 26468-26478, July 19, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/29/26468    most recent
M203527200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Henderson, M. J.
Right arrow Articles by Watts, C. K. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Henderson, M. J.
Right arrow Articles by Watts, C. K. W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response*

Michelle J. HendersonDagger , Amanda J. RussellDagger , Samantha HirdDagger , Marcia MuñozDagger , Jennifer L. ClancyDagger , Gillian M. LehrbachDagger , Sophina T. Calanni§, David A. Jans§, Robert L. SutherlandDagger , and Colin K. W. WattsDagger ||

From the Dagger  Cancer Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, 384 Victoria Street, Darlinghurst, New South Wales 2010, the § John Curtin School of Medical Research, Australian National University, P. O. Box 334, Canberra, Australian Capital Territory 2601, and the  Department of Biochemistry & Molecular Biology, Monash University, Box 13D, Clayton, Victoria 3800, Australia

The ubiquitin-protein ligase EDD encodes an orthologue of the hyperplastic discs tumor suppressor gene, which has a critical role in Drosophila development. Frequent allelic imbalance at the EDD chromosomal locus in human cancers suggests a role in tumorigenesis. In addition to a HECT (homologous to E6-AP carboxyl terminus) domain, the EDD protein contains a UBR1 zinc finger motif and ubiquitin-associated domain, each of which indicates involvement in ubiquitinylation pathways. This study shows that EDD interacts with importin alpha 5 through consensus basic nuclear localization signals and is localized in cell nuclei. EDD also binds progesterone receptor (PR) and potentiates progestin-mediated gene transactivation. This activity is comparable with that of the coactivator SRC-1, but, in contrast, the interaction between EDD and PR does not appear to involve an LXXLL receptor-binding motif. EDD also binds calcium- and integrin-binding protein/DNA-dependent protein kinase-interacting protein, a potential target of ubiquitin-mediated proteolysis, and an altered association is found between EDD and calcium- and integrin-binding protein/DNA-dependent protein kinase-interacting protein in response to DNA damage. The data presented here demonstrate a role for EDD in PR signaling but also suggest a link to cancer through DNA damage response pathways.

* This work was supported by the National Health and Medical Research Council of Australia, United States Army Medical Research and Materiel Command Breast Cancer Research Program Grants DAMD17-98-1-8335 and DAMD17-00-1-253, the Cancer Council New South Wales, the Leo and Jenny Leukemia and Cancer Foundation, the Kathleen Cuningham Foundation, and the Association for International Cancer Research.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

|| To whom correspondence should be addressed. Tel.: 61-2-92958331; Fax: 61-2-92958321; E-mail: c.watts@garvan.org.au.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
G. Kozlov, L. Nguyen, T. Lin, G. De Crescenzo, M. Park, and K. Gehring
Structural Basis of Ubiquitin Recognition by the Ubiquitin-associated (UBA) Domain of the Ubiquitin Ligase EDD
J. Biol. Chem., December 7, 2007; 282(49): 35787 - 35795.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
R. Ohshima, T. Ohta, W. Wu, A. Koike, T. Iwatani, M. Henderson, C. K. W. Watts, and T. Otsubo
Putative tumor suppressor EDD interacts with and up-regulates APC.
Genes Cells, December 1, 2007; 12(12): 1339 - 1345.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. Henderson, M. A. Munoz, D. N. Saunders, J. L. Clancy, A. J. Russell, B. Williams, D. Pappin, K. K. Khanna, S. P. Jackson, R. L. Sutherland, et al.
EDD Mediates DNA Damage-induced Activation of CHK2
J. Biol. Chem., December 29, 2006; 281(52): 39990 - 40000.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. S. Lim, G. Kozlov, T.-C. Chang, O. Groover, N. Siddiqui, L. Volpon, G. De Crescenzo, A.-B. Shyu, and K. Gehring
Comparative Peptide Binding Studies of the PABC Domains from the Ubiquitin-protein Isopeptide Ligase HYD and Poly(A)-binding Protein: IMPLICATIONS FOR HYD FUNCTION
J. Biol. Chem., May 19, 2006; 281(20): 14376 - 14382.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Tasaki, L. C. F. Mulder, A. Iwamatsu, M. J. Lee, I. V. Davydov, A. Varshavsky, M. Muesing, and Y. T. Kwon
A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons
Mol. Cell. Biol., August 15, 2005; 25(16): 7120 - 7136.
[Abstract] [Full Text] [PDF]

Home page
 Protein Sci.Home page
A. P. Yamniuk and H. J. Vogel
Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin {alpha}IIb cytoplasmic domain
Protein Sci., June 1, 2005; 14(6): 1429 - 1437.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. W. Vogel, Z. Zhuang, J. Li, H. Okamoto, M. Furuta, Y.-S. Lee, W. Zeng, E. H. Oldfield, A. O. Vortmeyer, and R. J. Weil
Proteins and Protein Pattern Differences between Glioma Cell Lines and Glioblastoma Multiforme
Clin. Cancer Res., May 15, 2005; 11(10): 3624 - 3632.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. N. Saunders, S. L. Hird, S. L. Withington, S. L. Dunwoodie, M. J. Henderson, C. Biben, R. L. Sutherland, C. J. Ormandy, and C. K. W. Watts
Edd, the Murine Hyperplastic Disc Gene, Is Essential for Yolk Sac Vascularization and Chorioallantoic Fusion
Mol. Cell. Biol., August 15, 2004; 24(16): 7225 - 7234.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. J. Fuja, F. Lin, K. E. Osann, and P. J. Bryant
Somatic Mutations and Altered Expression of the Candidate Tumor Suppressors CSNK1{epsilon}, DLG1, and EDD/hHYD in Mammary Ductal Carcinoma
Cancer Res., February 1, 2004; 64(3): 942 - 951.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. U. Naik and U. P. Naik
Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen
Blood, November 15, 2003; 102(10): 3629 - 3636.
[Abstract] [Full Text] [PDF]

Home page
 Protein Sci.Home page
N. Siddiqui, G. Kozlov, I. D'Orso, J.-F. Trempe, and K. Gehring
Solution structure of the C-terminal domain from poly(A)-binding protein in Trypanosoma cruzi: A vegetal PABC domain
Protein Sci., September 1, 2003; 12(9): 1925 - 1933.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
U. P. Naik and M. U. Naik
Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen
Blood, August 15, 2003; 102(4): 1355 - 1362.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. D. Lee, K. Amanai, A. Shearn, and J. E. Treisman
The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms
Development, March 14, 2003; 129(24): 5697 - 5706.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.