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J. Biol. Chem., Vol. 277, Issue 32, 28372-28375, August 9, 2002
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From the We identified Wengen, the first member of the
Drosophila tumor necrosis factor receptor (TNFR)
superfamily. Wengen is a type III membrane protein with conserved
cysteine-rich residues (TNFR homology domain) in the extracellular
domain, a hallmark of the TNFR superfamily. wengen mRNA
is expressed at all stages of Drosophila development. The
small-eye phenotype caused by an eye-specific overexpression of a
Drosophila TNF superfamily ligand, Eiger, was dramatically
suppressed by down-regulation of Wengen using RNA interference. In
addition, Wengen and Eiger physically interacted with each other
through their TNFR homology domain and TNF homology domain,
respectively. These results suggest that Wengen can act as a component
of a functional receptor for Eiger. Our identification of Wengen and
further genetic analysis should provide increased understanding of the
evolutionarily conserved roles of TNF/TNFR superfamily proteins in
normal development, as well as in some pathophysiological conditions.
ACCELERATED PUBLICATION
Wengen, a Member of the Drosophila Tumor Necrosis
Factor Receptor Superfamily, Is Required for Eiger Signaling*
§¶,
¶,**,
Laboratory for Cell Recovery Mechanisms,
Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, § Laboratories for Integrated Biology, Graduate School of
Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka
565-0871, and Department of Cell Biology and Neuroscience, Osaka
University Graduate School of Medicine, 2-2 Yamadaoka, Suita,
Osaka 565-0871, Japan
*
This work was supported in part by grants from the Japanese
Ministry of Education, Science, Sports, Culture, and Technology and a
RIKEN Bioarchitect Research Project (to M. M.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.:
81-48-467-6945; Fax: 81-48-467-6946; E-mail:
miura@brain.riken.go.jp.
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