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J. Biol. Chem., Vol. 277, Issue 33, 30091-30101, August 16, 2002
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From the Temporal expression profiling was utilized to
define transcriptional regulatory pathways in vivo in a
mouse muscle regeneration model. Potential downstream targets of MyoD
were identified by temporal expression, promoter data base mining, and
gel shift assays; Slug and calpain 6 were
identified as novel MyoD targets. Slug, a member of
the snail/slug family of zinc finger transcriptional repressors
critical for mesoderm/ectoderm development, was further shown to be a
downstream target by using promoter/reporter constructs and
demonstration of defective muscle regeneration in Slug null mice.
Slug Is a Novel Downstream Target of MyoD
TEMPORAL PROFILING IN MUSCLE REGENERATION*
,,
Research Center for Genetic Medicine,
Children's National Medical Center, and Genetics Program, George
Washington University, Washington, D. C. 20010, the
§ Muscle Gene Expression Group, Laboratory of Muscle
Biology, NIAMS, National Institutes of Health, Bethesda,
Maryland 20892, and ¶ The Jackson Laboratory, Bar Harbor,
Maine 04609
*
This work was supported by the Muscular Dystrophy
Association (to E. P. H.) and by Grants 1-UO1-HL66614 (to
E. P. H.), HOPGENE, and NIH-RO1-HD34883 (to T. G.) from the
Programs in Genomic Applications, NHLBI, National Institutes of Health.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Research Center
for Genetic Medicine, Children's National Medical Center, 111 Michigan
Ave. NW, Washington. D. C. 20010. Tel.: 202-884-6011; Fax:
202-884-6014; E-mail: ehoffman@cnmcresearch.org.
Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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